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NCT06264154 · ClinicalTrials.gov registry record · NA
The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
A NA study of Smoking and Tobacco Use, sponsored by Abramson Cancer Center at Penn Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 210
- Enrollment target
- 1
- Study location
NCT06264154: Recruiting NA study of Smoking and Tobacco Use, sponsored by Abramson Cancer Center at Penn Medicine.
NCT06264154 is a NA study of Smoking and Tobacco Use that is actively recruiting participants, run by Abramson Cancer Center at Penn Medicine. The registered enrollment target is 210 participants, below the 453-participant average among 123 other Smoking trials with a reported enrollment target (54% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06264154, a NA study of Smoking and Tobacco Use, is actively recruiting participants, sponsored by Abramson Cancer Center at Penn Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 210 participants
- Enrollment target
- 1
- Study location
Study Summary
This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to a six-week regimen of fruit-flavored, tobacco-flavored, or menthol-flavored e-cigarettes and be instructed to switch (versus smoking cigarettes) over a 6-week period. Flavor-associated subjective reward and the reinforcing value of flavored e-cigarettes relative to combustible cigarettes will be assessed as mechanisms.
Primary Outcome
The primary outcome is the longitudinal daily count of cigarettes from baseline to the end of the e-cigarette switch phase. Daily cigarette consumption will be determined by counting the daily spent cigarette filters returned for each of the 42 days (days 8 - 49).
Conditions Studied
Interventions
- OTHER E-cigarettes
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 210 participants |
| Start Date | 2024-08-26 |
| Est. Completion | 2027-12 |
| Phase | NA |
What NCT06264154 shows while recruiting
NCT06264154 is an interventional study that assigns participants to a tested intervention. The registered 210 participants enrollment target is mid-sized for trials with a published cap, below the 453-participant average among 123 other Smoking trials with a reported enrollment target (54% lower).
The record links to 4 conditions, with Smoking appearing as the primary indexed condition, and to 1 intervention - of which E-cigarettes is the first listed.
NCT06264154 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06264154 about?
NCT06264154 is a clinical study titled "The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers". This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to a six-week regimen of fruit-flavored, toba...
What is the current status of trial NCT06264154?
This trial is currently recruiting. It is a NA study. The enrollment target is 210 participants. The study started on 2024-08-26. Estimated completion is 2027-12.
What conditions does trial NCT06264154 study?
This clinical trial studies the following conditions: Smoking, Tobacco Use, Cigarette Smoking, E-Cig Use.
What interventions are being tested in trial NCT06264154?
The interventions under investigation include: E-cigarettes (OTHER).
Who is sponsoring clinical trial NCT06264154?
This trial is sponsored by Abramson Cancer Center at Penn Medicine, which has 402 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06264154 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Smoking
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06264154's enrollment target sits among peer trials
210 55th of 123 higher than 68 of 123 other Smoking trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Smoking trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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