Abramson Cancer Center at Penn Medicine
Trial Pipeline
Comparing Numbing Techniques in Mohs Micrographic Surgery
NCT07222241
Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema
NCT06837480
Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
NCT07199517
The Erector Spinae Plane Block For Gastrointestinal Malignancy Pain Treatment (EGIPT)
NCT07211386
Safe and Explainable AI
NCT06694181
CYTALUX for Intraoperative Imaging of Patients With Endometrial Cancer
NCT07278986
FTT PET/CT in Pancreatic Neuroendocrine Tumors
NCT07114939
Pembrolizumab and Odetiglucan in Liver Predominant Metastatic Colorectal Adenocarcinoma
NCT07082439
Vape Use Among Younger & Older Smokers
NCT07214168
Implementation of eHealth Delivery Alternatives for Cancer Genetic Testing for Hereditary Cancer (eREACH3)
NCT07471958
Telehealth Collaborative Care Model (CoCM) in Lung Cancer
NCT07102147
Practical Geriatric Assessment (PGA) Implementation Strategies and Correlative Evaluations (PACE-70)
NCT06870617
Maintenance Niraparib Plus Ipilimumab in Patients With Metastatic Pancreatic Adenocarcinoma Whose Disease Has Not Progressed on Platinum-Based Chemotherapy
NCT06747845
Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma
NCT06613841
Adjuvant Concurrent Immunotherapy and Radiotherapy for the Treatment of Bladder Cancer
NCT06586255
Healthy Volunteers Study
NCT06962059
Hypofractionated WPPT With HDR Boost
NCT06591819
BHB & CAR-T for Lymphomas
NCT06610344
QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer
NCT06551116
Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
NCT06372899
Community Support Program for Lung Cancer Screening Volume II
NCT06628167
Epcoritamab-CAR T Cells for Large B-cell Lymphomas
NCT06458439
Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis
NCT06578637
The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
NCT06264154
FAPI-74 PET/CT in Adults With Fibrosis
NCT06413355
Integrating Telehealth to Advance Lung Cancer Screening
NCT06638554
[18F]FES PET/.CT in Uterine Cancer
NCT05916196
Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]
NCT06125743
Assessment of a Radiomics-based Computer-Aided Diagnosis Tool for Pulmonary nodulES
NCT05968898
Prostate Tissue BioBank
NCT06659614
PROton Therapy for Post Surgical Treatment of GYNecologic Cancer
NCT05758688
Assessment of Geriatric Evaluations Impact on New AML Guidance
NCT05909501
FES BPET-DBT in Newly Diagnosed Breast Cancer
NCT05659797
Strategies to Close the Gap From Cervical Cancer Diagnosis to Treatment in Botswana
NCT05952141
Tocilizumab and Atezolizumab in Adults With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Refractory to 1st Line Immune Checkpoint Inhibitor-Based Therapy
NCT04691817
Limited-duration Teclistamab
NCT05932680
QOL and Sarcopenia in Patients With Ascites
NCT05726747
ChatBot and Activity Monitoring in Patients Undergoing Chemoradiotherapy
NCT05318027
Neoadjuvant Pembrolizumab and Lenvatinib for Renal Cell Carcinoma
NCT05733715
FTT PET/CT in Metastatic Prostate Cancer
NCT05242744
Collection of Circulating Biomarkers in Pancreatic Cancer
NCT05743049
Improve Outcomes for Older Allogeneic Transplant Recipients
NCT05612789
Neoadjuvant PD-1 Blockade in Resectable Merkel Cell Carcinoma
NCT05496036
WBSI Guided Personalized Delivery of TTFields
NCT05086497
Pembrolizumab in Combination With Chemotherapy and Image-Guided Surgery for Malignant Pleural Mesothelioma (MPM)
NCT03760575
Role of the Immune Environment in Response to Therapy in Breast Cancer
NCT05396612
eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Cancer
NCT05427240
SBRT With Atezo/Bev for HCC
NCT05488522
Comparing Two Ways to Manage Head and Neck Lymphedema
NCT05182229
CAR-T Followed by Bispecific Antibodies
NCT04889716
ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer
NCT04523857
CapTemY90 for Grade 2/3 NET Liver Metastases
NCT04339036
Avelumab or Hydroxychloroquine with or Without Palbociclib to Eliminate Dormant Breast Cancer
NCT04841148
CTNNA1 Familial Expansion Study
NCT05126290
Physiologic MR Imaging of Salivary Gland Tumors
NCT04452162
Carboplatin, Taxane And Ramucirumab for Patients With NSCLC After Pemetrexed or Pembrolizumab Maintenance
NCT04332367
Autoimmunity After Checkpoint Blockade
NCT04119713
Li-Fraumeni Syndrome/TP53 Biobank
NCT04367246
[18F] F-GLN by PET/CT in Breast Cancer
NCT03863457
Safety Trial of Antimicrobial Therapy and Precision Radiation Therapy in Patients With Oligoprogressive Non-small Cell Lung Cancer
NCT03546829
Ipilumumab and Nivolumab With or Without Hypofractionated Radiotherapy in Patients With Metastatic Melanoma
NCT03646617
Frailty Phenotype Assessments to Optimize Treatment Strategies for Older Patients With Hematologic Malignancies
NCT03680677
PENN-Surveillance Markers of Utility for Recurrence After (Neo)Adjuvant Therapy for Breast Cancer
NCT02732171
Phase I Pilot Study of Biodistribution, Metabolism and Excretion of Novel Radiotracer [18F]Fluorthanatrace (FTT) by PET/CT
NCT02637934
Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With Inherited Genetic Risk
NCT02478892
Ovarian Tissue Transplantation
NCT01870752
Protocol for Facilitating the Acquisition of Research Bone Marrow and Blood Samples
NCT01985919
The Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) Registry
NCT02346435
The Radiation Oncology Registry and Biosample Repository
NCT01577251
Increasing Screening for Cancer Using EHR-Nudges Replication
NCT06995703
Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer
NCT06436248
Early Point-of-Service Social and Behavioral Determinants of Health (SBDOH) Screening and Enhanced Navigation on Care Delivery for Patients With Breast Cancer
NCT06019988
Lipiodol Deposition Using Endhole vs. Pressure-Modulated Delivery
NCT06204159
Nudge to Gynecologic Oncology
NCT06451263
Project Looking-Glass Evaluation
NCT06056063
Increasing Adherence to Lung Cancer Screening
NCT05832008
Behavioral Economic Approaches for Population-Based Colorectal Cancer Screening
NCT05693649
The Association Between CBT-I Dose, Sleep Duration, and Fatigue in Breast Cancer Patients
NCT05226078
Shortened Course Adjuvant Radiotherapy Following TORS
NCT05714657
Vaccine Responses in Cancer
NCT06605625
Understanding Quality of Life Among Patients With Cancer Receiving Palliative Care
NCT05331625
RADVAX™ for Relapsed/Refractory Non-Hodgkin Lymphoma: A Phase II Trial of Pembrolizumab + Low Dose Radiotherapy
NCT04827862
Preliminary Investigation of β-hydroxybutyrate Supplementation in Colorectal Cancer Prevention
NCT05338307
XmAb20717 in Advanced Biliary Tract Cancers
NCT05297903
Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Prostate Cancer
NCT05096338
Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Breast Cancer
NCT05078190
Abbreviate or FAST Breast MRI for Supplemental Breast Cancer Screening for Black Women at Average Risk and Dense Breasts
NCT04854304
Telehealth Weight Loss Program for Breast Cancer Survivors
NCT04855552
Effectiveness of MyCancerGene to Optimize Genetic Testing Outcomes
NCT04774445
INO 5401 Vaccination in BRCA1/2 Mutation Carriers
NCT04367675
Implementation Strategies for Monitoring Adherence in Real Time
NCT04347161
BreastVAX: Radiation Boost to Enhance Immune Checkpoint Blockade Therapy
NCT04454528
Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy
NCT04305613
Adjuvant Treatment Determined By Pathological Response To Neoadjvuant Nivolumab
NCT04013854
Niraparib/TTFields in GBM
NCT04221503
BRCA1/2 Flu Vaccine
NCT04499534
Ostomy Rural Telehealth Training Cancer Survivors
NCT03913715
Neoadjuvant PD-1 Blockade in Patients with Stage IIB/C Melanoma
NCT03757689
TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck
NCT03729518
Personalized Radiation Therapy for GBM
NCT03477513
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 93 |
| Phase 2 | 79 |
| Phase 3 | 1 |
Therapeutic Areas
What the Pipeline for Abramson Cancer Center at Penn Medicine Shows
According to the ClinicalTrials.gov registry, Abramson Cancer Center at Penn Medicine is linked to 332 US clinical trials across every stage of research activity. Of those, 236 studies are currently recruiting — about 71% of the sponsor's indexed portfolio — and 52 are already marked complete, representing roughly 16% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for Abramson Cancer Center at Penn Medicine reports 1 late-stage studies (Phase 3 and Phase 4 combined) and 172 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for Abramson Cancer Center at Penn Medicine is Breast Cancer with 20 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.