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NCT06372899 · ClinicalTrials.gov registry record · NA

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

A NA study of Tobacco Use and Cigarette Smoking, sponsored by Abramson Cancer Center at Penn Medicine.

Recruiting
Registry status
NA
Development phase
200
Enrollment target
1
Study location

NCT06372899 is a NA study of Tobacco Use and Cigarette Smoking that is actively recruiting participants, run by Abramson Cancer Center at Penn Medicine. The registered enrollment target is 200 participants, below the 376-participant average among 76 other Tobacco Use trials with a reported enrollment target (47% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06372899, a NA study of Tobacco Use and Cigarette Smoking, is actively recruiting participants, sponsored by Abramson Cancer Center at Penn Medicine.

RECRUITING
Registry status
NA
Development phase
200 participants
Enrollment target
1
Study location

Study Summary

This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to ECIGS or ONPS and be instructed to switch (versus smoking cigarettes) over a 6-week period. Relative reductions in biomarkers of exposure will be measured. ECIG- and ONP-associated subjective reward and the reinforcing value of ECIGS and ONPS relative to combustible cigarettes will be assessed as mechanisms.

Conditions Studied

Tobacco Use Cigarette Smoking E-cigarette Use Harm Reduction

Interventions

  • OTHER E-cigarettes
  • OTHER Oral nicotine pouches

Study Locations (1)

Pennsylvania

  • University of Pennsylvania - Philadelphia

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2024-10-02
Est. Completion 2028-03-31
Phase NA

Sponsor

Abramson Cancer Center at Penn Medicine

402 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06372899

The ClinicalTrials.gov registry entry for NCT06372899 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 376-participant average among 76 other Tobacco Use trials with a reported enrollment target (47% lower). The listed sponsor is Abramson Cancer Center at Penn Medicine, which has 402 total studies on file at ClinicalTrials.gov.

The record links to 4 conditions, with Tobacco Use appearing as the primary indexed condition, and to 2 interventions - of which E-cigarettes is the first listed.

NCT06372899 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT06372899 about?

NCT06372899 is a clinical study titled "Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers". This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to ECIGS or ONPS and be instr...

What is the current status of trial NCT06372899?

This trial is currently recruiting. It is a NA study. The enrollment target is 200 participants. The study started on 2024-10-02. Estimated completion is 2028-03-31.

What conditions does trial NCT06372899 study?

This clinical trial studies the following conditions: Tobacco Use, Cigarette Smoking, E-cigarette Use, Harm Reduction.

What interventions are being tested in trial NCT06372899?

The interventions under investigation include: E-cigarettes (OTHER), Oral nicotine pouches (OTHER).

Who is sponsoring clinical trial NCT06372899?

This trial is sponsored by Abramson Cancer Center at Penn Medicine, which has 402 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06372899 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.