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NCT06372899 · ClinicalTrials.gov registry record · NA
Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
A NA study of Tobacco Use and Cigarette Smoking, sponsored by Abramson Cancer Center at Penn Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 200
- Enrollment target
- 1
- Study location
NCT06372899: Recruiting NA study of Tobacco Use and Cigarette Smoking, sponsored by Abramson Cancer Center at Penn Medicine.
NCT06372899 is a NA study of Tobacco Use and Cigarette Smoking that is actively recruiting participants, run by Abramson Cancer Center at Penn Medicine. The registered enrollment target is 200 participants, below the 376-participant average among 76 other Tobacco Use trials with a reported enrollment target (47% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06372899, a NA study of Tobacco Use and Cigarette Smoking, is actively recruiting participants, sponsored by Abramson Cancer Center at Penn Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to ECIGS or ONPS and be instructed to switch (versus smoking cigarettes) over a 6-week period. Relative reductions in biomarkers of exposure will be measured. ECIG- and ONP-associated subjective reward and the reinforcing value of ECIGS and ONPS relative to combustible cigarettes will be assessed as mechanisms.
Primary Outcome
The primary outcome is the longitudinal daily count of cigarettes from baseline to the end of the switch phase. Daily cigarette consumption will be determined by counting the daily spent cigarette filters returned for each of the 42 days (days 8 - 49).
Conditions Studied
Interventions
- OTHER E-cigarettes
- OTHER Oral nicotine pouches
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2024-10-02 |
| Est. Completion | 2028-03-31 |
| Phase | NA |
What NCT06372899 shows while recruiting
NCT06372899 is an interventional study that assigns participants to a tested intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 376-participant average among 76 other Tobacco Use trials with a reported enrollment target (47% lower).
The record links to 4 conditions, with Tobacco Use appearing as the primary indexed condition, and to 2 interventions - of which E-cigarettes is the first listed.
NCT06372899 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06372899 about?
NCT06372899 is a clinical study titled "Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers". This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to ECIGS or ONPS and be instr...
What is the current status of trial NCT06372899?
This trial is currently recruiting. It is a NA study. The enrollment target is 200 participants. The study started on 2024-10-02. Estimated completion is 2028-03-31.
What conditions does trial NCT06372899 study?
This clinical trial studies the following conditions: Tobacco Use, Cigarette Smoking, E-cigarette Use, Harm Reduction.
What interventions are being tested in trial NCT06372899?
The interventions under investigation include: E-cigarettes (OTHER), Oral nicotine pouches (OTHER).
Who is sponsoring clinical trial NCT06372899?
This trial is sponsored by Abramson Cancer Center at Penn Medicine, which has 402 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06372899 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Tobacco Use
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06372899's enrollment target sits among peer trials
200 27th of 76 higher than 50 of 76 other Tobacco Use trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Tobacco Use trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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