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Acute Kidney Injury clinical trials
Every US clinical trial registered for Acute Kidney Injury — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
75 US clinical trials · 33 currently recruiting
The research picture
Acute Kidney Injury has 75 registered US clinical trials, 33 of them open to new participants right now — about 44% of the total.
- 33
- recruiting participants now
- 44%
- of trials open to enrollment
- 6
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Brigham and Women's Hospital
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry
Potrero Medical
NCT04669548
A Patient-centered Trial of a Process-of-care Intervention in Hospitalized AKI Patients: the COPE-AKI Trial
University of Pittsburgh
NCT05805709
KIDney Injury in Times of COVID-19 (KIDCOV)
University of California, San Francis
NCT04705766
Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
University of Colorado, Denver
NCT06349577
CTSN Embolic Protection Trial
Icahn School of Medicine at Mount Sinai
NCT06027788
Combining Biomarkers and Electronic Risk Scores to Predict AKI in Hospitalized Patients
University of Chicago
NCT05988658
A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients
University of Pennsylvania
NCT06954129
Novel Treatments in Improving Renal Outcomes in Light Chain Cast Nephropathy
Brigham and Women's Hospital
NCT06483139
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)
The University of Texas Health Science Center, Houston
NCT06706258
NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial
Kaiser Permanente
NCT04750616
Melatonin for Prevention of Kidney Injury
Rutgers, The State University of New Jersey
NCT05084196
Low Dose Vasopressin vs Phenylephrine in Cardiac Surgery
Thomas Jefferson University
NCT04602767
QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry
SeaStar Medical
NCT06517810
Kidney Function in People With Cystic Fibrosis in the Era of HEMT
University of Virginia
NCT06595420
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
VA Office of Research and Development
NCT04982419
Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury
SeaStar Medical
NCT05758077
Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome
Yale University
NCT07273838
Groundbreaking Renal Assist Device Intervening to ENhance cardioThoracic Surgery Outcomes
3ive Labs
NCT07017933
A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.
AstraZeneca
NCT07215702
Acute Normovolemic Hemodilution on Urine Neutrophil Gelatinase-associated Lipocalin Levels
University of Maryland, Baltimore
NCT05349292
Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in Hemorrhagic Shock Patients
The University of Texas Health Science Center, Houston
NCT06531642
Cystatin and Early AKI Detection Contrast Induced Acute Kidney Injury
BayCare Health System
NCT07197957
Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury
Giuseppe Cullaro, MD
NCT06937307
Nafamostat Efficacy in Phase 3 Registrational CRRT Study
Talphera
NCT06150742
Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury
Hope Biosciences
NCT06654193
Optimizing Pulsatility During Cardiopulmonary Bypass
University of Colorado, Denver
NCT05344573
SAfety of Regional Citrate Anticoagulation (SARCA Study)
Fresenius Medical Care North America
NCT05339139
Initial Resuscitation for Acute Kidney Injury in Cirrhosis
Massachusetts General Hospital
NCT06525623
The Biosonographic Index
University of Alabama at Birmingham
NCT04144894
Ultra-Low Contrast Angiography in AKI
Tulane University
NCT05906758
Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage
Medical College of Wisconsin
NCT05853601
A Study of Facilitators and Barriers to Improve Acute Kidney Injury in Children Through Mobile Health Intervention
Duke University
NCT04403633
Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat
University of Northern Iowa
NCT07472426
Establishment of ProNephro AKI (NGAL) Cut Off Value for Risk Assessment of Moderate to Severe Acute Kidney Injury in Adults
BioPorto Diagnostics
NCT06652100
Clinical Validation of the RENISCHEM L-FABP POC Assay
Hikari Dx
NCT04864847
Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury
Brigham and Women's Hospital
NCT04633889
Network Analysis of Urinary Molecular Signature Complements Clinical Data to Predict Postoperative Acute Kidney Injury
University of Florida
NCT02114138
An Early Real-Time Electronic Health Record Risk Algorithm for the Prevention and Treatment of Acute Kidney Injury
University of Chicago
NCT03590028
A Study of Auxora in Patients With AKI and Injurious Lung "Crosstalk"
CalciMedica
NCT06374797
Acute Kidney Injury Genomics and Biomarkers in TAVR Study
University of Texas Southwestern Medical Center
NCT02791880
Prospective, Multi-center, Single-arm, Observational Study. US FDA 522 Pediatric Post Market Surveillance Study.
Medtronic - MITG
NCT04608149
Critical Illness Myopathy and Trajectory of Recovery in AKI Requiring CRRT
University of Iowa
NCT05287204
Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study)
Massachusetts General Hospital
NCT02105298
Saline Against Lactated Ringers or Plasmalyte in the Emergency Department
Vanderbilt University
NCT02614040
Pediatric Acute Kidney Injury (AKI) Retrospective, Real-Time and Repository Research
Vanderbilt University Medical Center
NCT02660931
Isotonic Solutions and Major Adverse Renal Events Trial in the Non-Medical Intensive Care Unit (SMART-SURG)
Vanderbilt University
NCT02547779
Perioperative Outcome Risk Assessment With Computer Learning Enhancement
Washington University School of Medicine
NCT05042804
Personalized Recommendations for Acute Kidney Injury (AKI) Care
Yale University
NCT04040296
International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI Project
Azienda Ospedaliera di Padova
NCT05387811
Does the Presence of Preoperative Proteinuria Predict Postoperative Acute Kidney Injury in Obese Patients Undergoing Elective Laparoscopic Surgery?
NYU Langone Health
NCT02798042
Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin Evaluation of Symptomatic Heart Failure Study
Alere San Diego
NCT01291836
The Drug Induced Renal Injury Consortium
Ravindra Mehta
NCT02159209
A Safety, Tolerability, Efficacy and QoL Study of Human recAP in the Treatment of Patients With SA-AKI
AM-Pharma
NCT02182440
NGAL As An Aid for the Diagnosis of Acute Kidney Injury in Intensive Care
BioPorto Diagnostics
NCT02121470
Acute Kidney Injury in Premature Infants
University of Alabama at Birmingham
NCT00573079
Evaluation of Catheter Placement for Renal Replacement Therapy in Patients With Acute Kidney Injury
Brigham and Women's Hospital
NCT02200120
Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury
David Leaf
NCT02962102
Assessment of Urinary Neutrophil Gelatinase-Associated Lipocalin to Predict AKI in the NICU
University of Alabama at Birmingham
NCT04354467
Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury
Centre hospitalier de l'Université de Montréal (CHUM)
NCT04095143
Specimen Stability Study
Astute Medical
NCT01846884
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor
The University of Texas Health Science Center, Houston
NCT06154226
Acute Normovolemic Hemodilution in Complex Cardiac Surgery
University of California, Los Angeles
NCT05049590
Molecular Effects of Vitamin B3 (Niacinamide) in Acute Kidney Injury
Beth Israel Deaconess Medical Center
NCT02701127
The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction
Mayo Clinic
NCT02554253
A Study of OCE-205 in Participants With Cirrhosis With Ascites Who Developed Hepatorenal Syndrome-Acute Kidney Injury
Ocelot Bio
NCT05309200
Intermittent Hypoxemia and Acute Kidney Injury Study (IHAKI Study)
Elie G. Abu Jawdeh, MD
NCT02837276
FAST GFR: Pilot Study to Evaluate the Safety of the FAST GFR Test in Patients.
FAST BioMedical
NCT01978314
The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of FAST PV and mGFR Technology™
FAST BioMedical
NCT03095391
Fluid Chloride and AKI in Cardiopulmonary Bypass
University of New Mexi
NCT02668952
Nicotinamide Riboside in SARS-CoV-2 (COVID-19) Patients for Renal Protection
The University of Texas Health Science Center at San Antonio
NCT04818216
Pharmacokinetics of Antiepileptics in Patients on CRRT
University of Maryland, Baltimore
NCT03632915
Pharmacokinetics of MP-3180 and Use of Noninvasive Fluorescence Detection Device in Healthy Volunteers
MediBeacon
NCT02098187
Tolerability and Background Fluorescence of the MediBeacon Transdermal GFR Measurement System
MediBeacon
NCT03810833
Ibuprofen and Biomarkers of Acute Kidney Injury After Running in the Heat
University of New Mexi
NCT06247462
A Study of the PK Interaction of CXA-10 With Pravastatin and Vytorin® in Healthy Males
Complexa
NCT02547402
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 16 |
| Phase 3 | 4 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Acute Kidney Injury Trial Landscape
ClinicalTrials.gov lists 75 US studies indexed under Acute Kidney Injury, and 33 of those are currently open to recruitment — roughly 44% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Acute Kidney Injury shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 22 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Acute Kidney Injury is led by Brigham and Women's Hospital with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 75 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Acute Kidney Injury?
PlainTrial tracks 75 US clinical trials for Acute Kidney Injury, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Acute Kidney Injury?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.