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Acute Kidney Injury: early-phase trial registry
33 of 75 indexed Acute Kidney Injury trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #178 of 28,707 conditions by registered trial count.
75 US clinical trials · 33 currently recruiting · #178 of 28,707 conditions by registered trial count
Acute Kidney Injury: 75 US clinical trials tracked, 33 recruiting.
Acute Kidney Injury is the subject of 75 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Brigham and Women's Hospital, running 3 of these trials.
Enrollment posture brief
Registry condition acute-kidney-injury
OPEN 33 | RECR 44% | LATE 6 | EARLY 22 | RANK #178 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Acute Lymphoblastic Leukemia (44% recruiting · 132 trials)
Acute Kidney Injury lists 33 open slots (44% of 75 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Acute Kidney Injury on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Acute Kidney Injury is recruiting above its size-band peers.
33 of 75 indexed trials (44%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Acute Kidney Injury trials is spread across many organizations.
Brigham and Women's Hospital accounts for 3 of 75 trials (4%). 58 distinct sponsors appear on at least one study for this condition label.
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Typical Acute Kidney Injury enrolment sits around 148 participants.
Median target enrolment is 148 among the 75 trials that report a genuine target (sentinel values excluded). 28 of those (37.3%) plan for fewer than 100 participants.
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Acute Kidney Injury splits between interventional and observational designs.
46 interventional and 29 observational studies make up this index (61.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
75 total, page 1 of 2
Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry
Potrero Medical
NCT04669548
A Patient-centered Trial of a Process-of-care Intervention in Hospitalized AKI Patients: the COPE-AKI Trial
University of Pittsburgh
NCT05805709
KIDney Injury in Times of COVID-19 (KIDCOV)
University of California, San Francisco
NCT04705766
Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
University of Colorado, Denver
NCT06349577
CTSN Embolic Protection Trial
Icahn School of Medicine at Mount Sinai
NCT06027788
Combining Biomarkers and Electronic Risk Scores to Predict AKI in Hospitalized Patients
University of Chicago
NCT05988658
A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients
University of Pennsylvania
NCT06954129
Novel Treatments in Improving Renal Outcomes in Light Chain Cast Nephropathy
Brigham and Women's Hospital
NCT06483139
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)
The University of Texas Health Science Center, Houston
NCT06706258
NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial
Kaiser Permanente
NCT04750616
Melatonin for Prevention of Kidney Injury
Rutgers, The State University of New Jersey
NCT05084196
Low Dose Vasopressin vs Phenylephrine in Cardiac Surgery
Thomas Jefferson University
NCT04602767
QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry
SeaStar Medical
NCT06517810
Kidney Function in People With Cystic Fibrosis in the Era of HEMT
University of Virginia
NCT06595420
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
VA Office of Research and Development
NCT04982419
Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury
SeaStar Medical
NCT05758077
Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome
Yale University
NCT07273838
Groundbreaking Renal Assist Device Intervening to ENhance cardioThoracic Surgery Outcomes
3ive Labs
NCT07017933
A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.
AstraZeneca
NCT07215702
Acute Normovolemic Hemodilution on Urine Neutrophil Gelatinase-associated Lipocalin Levels
University of Maryland, Baltimore
NCT05349292
Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in Hemorrhagic Shock Patients
The University of Texas Health Science Center, Houston
NCT06531642
Cystatin and Early AKI Detection Contrast Induced Acute Kidney Injury
BayCare Health System
NCT07197957
Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury
Giuseppe Cullaro, MD
NCT06937307
Nafamostat Efficacy in Phase 3 Registrational CRRT Study
Talphera
NCT06150742
Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury
Hope Biosciences
NCT06654193
Optimizing Pulsatility During Cardiopulmonary Bypass
University of Colorado, Denver
NCT05344573
SAfety of Regional Citrate Anticoagulation (SARCA Study)
Fresenius Medical Care North America
NCT05339139
Initial Resuscitation for Acute Kidney Injury in Cirrhosis
Massachusetts General Hospital
NCT06525623
The Biosonographic Index
University of Alabama at Birmingham
NCT04144894
Ultra-Low Contrast Angiography in AKI
Tulane University
NCT05906758
Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage
Medical College of Wisconsin
NCT05853601
A Study of Facilitators and Barriers to Improve Acute Kidney Injury in Children Through Mobile Health Intervention
Duke University
NCT04403633
Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat
University of Northern Iowa
NCT07472426
Establishment of ProNephro AKI (NGAL) Cut Off Value for Risk Assessment of Moderate to Severe Acute Kidney Injury in Adults
BioPorto Diagnostics
NCT06652100
Clinical Validation of the RENISCHEM L-FABP POC Assay
Hikari Dx
NCT04864847
Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury
Brigham and Women's Hospital
NCT04633889
Network Analysis of Urinary Molecular Signature Complements Clinical Data to Predict Postoperative Acute Kidney Injury
University of Florida
NCT02114138
An Early Real-Time Electronic Health Record Risk Algorithm for the Prevention and Treatment of Acute Kidney Injury
University of Chicago
NCT03590028
A Study of Auxora in Patients With AKI and Injurious Lung "Crosstalk"
CalciMedica
NCT06374797
Acute Kidney Injury Genomics and Biomarkers in TAVR Study
University of Texas Southwestern Medical Center
NCT02791880
Prospective, Multi-center, Single-arm, Observational Study. US FDA 522 Pediatric Post Market Surveillance Study.
Medtronic - MITG
NCT04608149
Critical Illness Myopathy and Trajectory of Recovery in AKI Requiring CRRT
University of Iowa
NCT05287204
Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study)
Massachusetts General Hospital
NCT02105298
Saline Against Lactated Ringers or Plasmalyte in the Emergency Department
Vanderbilt University
NCT02614040
Pediatric Acute Kidney Injury (AKI) Retrospective, Real-Time and Repository Research
Vanderbilt University Medical Center
NCT02660931
Isotonic Solutions and Major Adverse Renal Events Trial in the Non-Medical Intensive Care Unit (SMART-SURG)
Vanderbilt University
NCT02547779
Perioperative Outcome Risk Assessment With Computer Learning Enhancement
Washington University School of Medicine
NCT05042804
Personalized Recommendations for Acute Kidney Injury (AKI) Care
Yale University
NCT04040296
International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI Project
Azienda Ospedaliera di Padova
NCT05387811
Does the Presence of Preoperative Proteinuria Predict Postoperative Acute Kidney Injury in Obese Patients Undergoing Elective Laparoscopic Surgery?
NYU Langone Health
NCT02798042
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 16 |
| Phase 3 | 4 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Acute Kidney Injury records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Acute Kidney Injury trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Acute Kidney Injury page
75 registered trials, 33 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 33 Acute Kidney Injury trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Brigham and Women's Hospital sponsors the most Acute Kidney Injury trials on record, review their full trial history before evaluating a specific study. See Brigham and Women's Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Acute Kidney Injury condition card totals 75 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.