Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 33 recruiting now official registry

Acute Kidney Injury clinical trials

Every US clinical trial registered for Acute Kidney Injury — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

75 US clinical trials · 33 currently recruiting

The research picture

Acute Kidney Injury has 75 registered US clinical trials, 33 of them open to new participants right now — about 44% of the total.

33
recruiting participants now
44%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
3
top sponsor: Brigham and Women's Hospital

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 2,500 participants

Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry

Potrero Medical

NCT04669548

RECRUITING NA 2,145 participants

A Patient-centered Trial of a Process-of-care Intervention in Hospitalized AKI Patients: the COPE-AKI Trial

University of Pittsburgh

NCT05805709

RECRUITING 2,000 participants

KIDney Injury in Times of COVID-19 (KIDCOV)

University of California, San Francis

NCT04705766

RECRUITING NA 1,100 participants

Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury

University of Colorado, Denver

NCT06349577

RECRUITING NA 842 participants

CTSN Embolic Protection Trial

Icahn School of Medicine at Mount Sinai

NCT06027788

RECRUITING 800 participants

Combining Biomarkers and Electronic Risk Scores to Predict AKI in Hospitalized Patients

University of Chicago

NCT05988658

RECRUITING Phase 4 750 participants

A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients

University of Pennsylvania

NCT06954129

RECRUITING 450 participants

Novel Treatments in Improving Renal Outcomes in Light Chain Cast Nephropathy

Brigham and Women's Hospital

NCT06483139

RECRUITING Phase 2 400 participants

Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)

The University of Texas Health Science Center, Houston

NCT06706258

RECRUITING Phase 2 304 participants

NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial

Kaiser Permanente

NCT04750616

RECRUITING Phase 3 300 participants

Melatonin for Prevention of Kidney Injury

Rutgers, The State University of New Jersey

NCT05084196

RECRUITING Phase 4 300 participants

Low Dose Vasopressin vs Phenylephrine in Cardiac Surgery

Thomas Jefferson University

NCT04602767

RECRUITING 300 participants

QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry

SeaStar Medical

NCT06517810

RECRUITING 260 participants

Kidney Function in People With Cystic Fibrosis in the Era of HEMT

University of Virginia

NCT06595420

RECRUITING Phase 2 240 participants

Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial

VA Office of Research and Development

NCT04982419

RECRUITING NA 200 participants

Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury

SeaStar Medical

NCT05758077

RECRUITING Phase 2 130 participants

Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome

Yale University

NCT07273838

RECRUITING NA 124 participants

Groundbreaking Renal Assist Device Intervening to ENhance cardioThoracic Surgery Outcomes

3ive Labs

NCT07017933

RECRUITING Phase 2 124 participants

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

AstraZeneca

NCT07215702

RECRUITING 100 participants

Acute Normovolemic Hemodilution on Urine Neutrophil Gelatinase-associated Lipocalin Levels

University of Maryland, Baltimore

NCT05349292

RECRUITING Phase 2 100 participants

Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in Hemorrhagic Shock Patients

The University of Texas Health Science Center, Houston

NCT06531642

RECRUITING 100 participants

Cystatin and Early AKI Detection Contrast Induced Acute Kidney Injury

BayCare Health System

NCT07197957

RECRUITING Phase 2 75 participants

Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury

Giuseppe Cullaro, MD

NCT06937307

RECRUITING NA 70 participants

Nafamostat Efficacy in Phase 3 Registrational CRRT Study

Talphera

NCT06150742

RECRUITING Phase 1 70 participants

Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury

Hope Biosciences

NCT06654193

RECRUITING 66 participants

Optimizing Pulsatility During Cardiopulmonary Bypass

University of Colorado, Denver

NCT05344573

RECRUITING Phase 3 50 participants

SAfety of Regional Citrate Anticoagulation (SARCA Study)

Fresenius Medical Care North America

NCT05339139

RECRUITING NA 50 participants

Initial Resuscitation for Acute Kidney Injury in Cirrhosis

Massachusetts General Hospital

NCT06525623

RECRUITING NA 50 participants

The Biosonographic Index

University of Alabama at Birmingham

NCT04144894

RECRUITING Phase 3 32 participants

Ultra-Low Contrast Angiography in AKI

Tulane University

NCT05906758

RECRUITING Phase 1 30 participants

Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage

Medical College of Wisconsin

NCT05853601

RECRUITING NA 25 participants

A Study of Facilitators and Barriers to Improve Acute Kidney Injury in Children Through Mobile Health Intervention

Duke University

NCT04403633

RECRUITING NA 20 participants

Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat

University of Northern Iowa

NCT07472426

ACTIVE NOT RECRUITING 800 participants

Establishment of ProNephro AKI (NGAL) Cut Off Value for Risk Assessment of Moderate to Severe Acute Kidney Injury in Adults

BioPorto Diagnostics

NCT06652100

ACTIVE NOT RECRUITING 450 participants

Clinical Validation of the RENISCHEM L-FABP POC Assay

Hikari Dx

NCT04864847

ACTIVE NOT RECRUITING Phase 2 320 participants

Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury

Brigham and Women's Hospital

NCT04633889

ACTIVE NOT RECRUITING 240 participants

Network Analysis of Urinary Molecular Signature Complements Clinical Data to Predict Postoperative Acute Kidney Injury

University of Florida

NCT02114138

ACTIVE NOT RECRUITING NA 180 participants

An Early Real-Time Electronic Health Record Risk Algorithm for the Prevention and Treatment of Acute Kidney Injury

University of Chicago

NCT03590028

ACTIVE NOT RECRUITING Phase 2 150 participants

A Study of Auxora in Patients With AKI and Injurious Lung "Crosstalk"

CalciMedica

NCT06374797

ACTIVE NOT RECRUITING 62 participants

Acute Kidney Injury Genomics and Biomarkers in TAVR Study

University of Texas Southwestern Medical Center

NCT02791880

ACTIVE NOT RECRUITING 36 participants

Prospective, Multi-center, Single-arm, Observational Study. US FDA 522 Pediatric Post Market Surveillance Study.

Medtronic - MITG

NCT04608149

ACTIVE NOT RECRUITING 10 participants

Critical Illness Myopathy and Trajectory of Recovery in AKI Requiring CRRT

University of Iowa

NCT05287204

COMPLETED 104,000 participants

Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study)

Massachusetts General Hospital

NCT02105298

COMPLETED NA 14,000 participants

Saline Against Lactated Ringers or Plasmalyte in the Emergency Department

Vanderbilt University

NCT02614040

COMPLETED NA 12,108 participants

Pediatric Acute Kidney Injury (AKI) Retrospective, Real-Time and Repository Research

Vanderbilt University Medical Center

NCT02660931

COMPLETED NA 10,421 participants

Isotonic Solutions and Major Adverse Renal Events Trial in the Non-Medical Intensive Care Unit (SMART-SURG)

Vanderbilt University

NCT02547779

COMPLETED NA 5,114 participants

Perioperative Outcome Risk Assessment With Computer Learning Enhancement

Washington University School of Medicine

NCT05042804

COMPLETED NA 4,003 participants

Personalized Recommendations for Acute Kidney Injury (AKI) Care

Yale University

NCT04040296

COMPLETED 1,456 participants

International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI Project

Azienda Ospedaliera di Padova

NCT05387811

COMPLETED 1,434 participants

Does the Presence of Preoperative Proteinuria Predict Postoperative Acute Kidney Injury in Obese Patients Undergoing Elective Laparoscopic Surgery?

NYU Langone Health

NCT02798042

COMPLETED 930 participants

Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin Evaluation of Symptomatic Heart Failure Study

Alere San Diego

NCT01291836

COMPLETED 634 participants

The Drug Induced Renal Injury Consortium

Ravindra Mehta

NCT02159209

COMPLETED Phase 2 301 participants

A Safety, Tolerability, Efficacy and QoL Study of Human recAP in the Treatment of Patients With SA-AKI

AM-Pharma

NCT02182440

COMPLETED 252 participants

NGAL As An Aid for the Diagnosis of Acute Kidney Injury in Intensive Care

BioPorto Diagnostics

NCT02121470

COMPLETED 237 participants

Acute Kidney Injury in Premature Infants

University of Alabama at Birmingham

NCT00573079

COMPLETED 150 participants

Evaluation of Catheter Placement for Renal Replacement Therapy in Patients With Acute Kidney Injury

Brigham and Women's Hospital

NCT02200120

COMPLETED Phase 2 150 participants

Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury

David Leaf

NCT02962102

COMPLETED 148 participants

Assessment of Urinary Neutrophil Gelatinase-Associated Lipocalin to Predict AKI in the NICU

University of Alabama at Birmingham

NCT04354467

COMPLETED 125 participants

Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury

Centre hospitalier de l'Université de Montréal (CHUM)

NCT04095143

COMPLETED 124 participants

Specimen Stability Study

Astute Medical

NCT01846884

COMPLETED Phase 2 100 participants

Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor

The University of Texas Health Science Center, Houston

NCT06154226

COMPLETED Phase 3 63 participants

Acute Normovolemic Hemodilution in Complex Cardiac Surgery

University of California, Los Angeles

NCT05049590

COMPLETED Early Phase 1 55 participants

Molecular Effects of Vitamin B3 (Niacinamide) in Acute Kidney Injury

Beth Israel Deaconess Medical Center

NCT02701127

COMPLETED Phase 2 52 participants

The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction

Mayo Clinic

NCT02554253

COMPLETED Phase 2 47 participants

A Study of OCE-205 in Participants With Cirrhosis With Ascites Who Developed Hepatorenal Syndrome-Acute Kidney Injury

Ocelot Bio

NCT05309200

COMPLETED 41 participants

Intermittent Hypoxemia and Acute Kidney Injury Study (IHAKI Study)

Elie G. Abu Jawdeh, MD

NCT02837276

COMPLETED NA 33 participants

FAST GFR: Pilot Study to Evaluate the Safety of the FAST GFR Test in Patients.

FAST BioMedical

NCT01978314

COMPLETED 32 participants

The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of FAST PV and mGFR Technology™

FAST BioMedical

NCT03095391

COMPLETED Phase 2 30 participants

Fluid Chloride and AKI in Cardiopulmonary Bypass

University of New Mexi

NCT02668952

COMPLETED Phase 2 28 participants

Nicotinamide Riboside in SARS-CoV-2 (COVID-19) Patients for Renal Protection

The University of Texas Health Science Center at San Antonio

NCT04818216

COMPLETED 18 participants

Pharmacokinetics of Antiepileptics in Patients on CRRT

University of Maryland, Baltimore

NCT03632915

COMPLETED Phase 1 16 participants

Pharmacokinetics of MP-3180 and Use of Noninvasive Fluorescence Detection Device in Healthy Volunteers

MediBeacon

NCT02098187

COMPLETED NA 12 participants

Tolerability and Background Fluorescence of the MediBeacon Transdermal GFR Measurement System

MediBeacon

NCT03810833

COMPLETED Phase 1 12 participants

Ibuprofen and Biomarkers of Acute Kidney Injury After Running in the Heat

University of New Mexi

NCT06247462

COMPLETED Phase 1 10 participants

A Study of the PK Interaction of CXA-10 With Pravastatin and Vytorin® in Healthy Males

Complexa

NCT02547402

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 16
Phase 3 4
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Kidney Injury Trial Landscape

ClinicalTrials.gov lists 75 US studies indexed under Acute Kidney Injury, and 33 of those are currently open to recruitment — roughly 44% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Acute Kidney Injury shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 22 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Acute Kidney Injury is led by Brigham and Women's Hospital with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 75 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Kidney Injury?

PlainTrial tracks 75 US clinical trials for Acute Kidney Injury, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Kidney Injury?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →