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NCT05999383 · ClinicalTrials.gov registry record · Phase 2
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
A Phase 2 study of Tobacco Use and Cannabis Use, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 48
- Enrollment target
- 1
- Study location
NCT05999383: Recruiting Phase 2 study of Tobacco Use and Cannabis Use, sponsored by University of California, San Francisco.
NCT05999383 is a Phase 2 study of Tobacco Use and Cannabis Use that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 48 participants, below the 378-participant average among 76 other Tobacco Use trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05999383, a Phase 2 study of Tobacco Use and Cannabis Use, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco. The project aims to describe the pharmacokinetics and pharmacodynamics of marijuana-tobacco co-administration by delivering THC and nicotine in various combinations. This foundational study will establish a research program focused on elucidating the public health consequences of marijuana-tobacco co-use.
Primary Outcome
To assess the differences between THC dosages, the study investigators will determine maximum plasma THC concentration (Cmax) using plasma THC concentrations from the standardized sessions.
Conditions Studied
Interventions
- DRUG Nicotine
- DRUG Cannabis
- DEVICE Pax Loose Leaf Vaporizer
- OTHER Placebo Marijuana
Study Locations (1)
California
- Zuckerberg San Francisco General Hospital - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2025-07-01 |
| Est. Completion | 2028-02-01 |
| Phase | Phase 2 |
What NCT05999383 shows while recruiting
NCT05999383 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 378-participant average among 76 other Tobacco Use trials with a reported enrollment target (87% lower).
The record links to 6 conditions, with Tobacco Use appearing as the primary indexed condition, and to 4 interventions - of which Nicotine is the first listed.
NCT05999383 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05999383 about?
NCT05999383 is a clinical study titled "Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration". This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco. The project aims to describe the pharmacokinetics and pharmacodynamics of marijuana-tobacco co-admin...
What is the current status of trial NCT05999383?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 48 participants. The study started on 2025-07-01. Estimated completion is 2028-02-01.
What conditions does trial NCT05999383 study?
This clinical trial studies the following conditions: Tobacco Use, Cannabis Use, Cannabis, Vaping, THC.
What interventions are being tested in trial NCT05999383?
The interventions under investigation include: Nicotine (DRUG), Cannabis (DRUG), Pax Loose Leaf Vaporizer (DEVICE), Placebo Marijuana (OTHER).
Who is sponsoring clinical trial NCT05999383?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05999383 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Tobacco Use
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05999383's enrollment target sits among peer trials
48 57th of 76 higher than 20 of 76 other Tobacco Use trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Tobacco Use trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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