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NCT05999383 · ClinicalTrials.gov registry record · Phase 2
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
A Phase 2 study of Tobacco Use and Cannabis Use, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 48
- Enrollment target
- 1
- Study location
NCT05999383 is a Phase 2 study of Tobacco Use and Cannabis Use that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 48 participants, below the 378-participant average among 76 other Tobacco Use trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05999383, a Phase 2 study of Tobacco Use and Cannabis Use, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco. The project aims to describe the pharmacokinetics and pharmacodynamics of marijuana-tobacco co-administration by delivering THC and nicotine in various combinations. This foundational study will establish a research program focused on elucidating the public health consequences of marijuana-tobacco co-use.
Conditions Studied
Interventions
- DRUG Nicotine
- DRUG Cannabis
- DEVICE Pax Loose Leaf Vaporizer
- OTHER Placebo Marijuana
Study Locations (1)
California
- Zuckerberg San Francisco General Hospital - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2025-07-01 |
| Est. Completion | 2028-02-01 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05999383
The ClinicalTrials.gov registry entry for NCT05999383 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 48 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 378-participant average among 76 other Tobacco Use trials with a reported enrollment target (87% lower). The listed sponsor is University of California, San Francisco, which has 1,713 total studies on file at ClinicalTrials.gov.
The record links to 6 conditions, with Tobacco Use appearing as the primary indexed condition, and to 4 interventions - of which Nicotine is the first listed.
NCT05999383 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT05999383 about?
NCT05999383 is a clinical study titled "Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration". This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco. The project aims to describe the pharmacokinetics and pharmacodynamics of marijuana-tobacco co-admin...
What is the current status of trial NCT05999383?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 48 participants. The study started on 2025-07-01. Estimated completion is 2028-02-01.
What conditions does trial NCT05999383 study?
This clinical trial studies the following conditions: Tobacco Use, Cannabis Use, Cannabis, Vaping, THC.
What interventions are being tested in trial NCT05999383?
The interventions under investigation include: Nicotine (DRUG), Cannabis (DRUG), Pax Loose Leaf Vaporizer (DEVICE), Placebo Marijuana (OTHER).
Who is sponsoring clinical trial NCT05999383?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05999383 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.