Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 71 recruiting now official registry

Post Traumatic Stress Disorder clinical trials

71 of 146 indexed Post Traumatic Stress Disorder trials are currently recruiting.

146 US clinical trials · 71 currently recruiting

Post Traumatic Stress Disorder is the subject of 146 registered US clinical trials on ClinicalTrials.gov, 71 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 30 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 19 of these trials.

The research picture

Post Traumatic Stress Disorder has 146 registered US clinical trials, 71 of them open to new participants right now, about 49% of the total.

71
recruiting participants now
49%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
19
top sponsor: VA Office of Research and Development
Phase 18Phase 222Phase 38Phase 45

Active & Recent Trials

146 total, page 2 of 3

RECRUITING NA 66 participants

Disrupting Fear-based Memory Consolidation

Emory University

NCT05560113

RECRUITING NA 60 participants

TMS-fNIRS Personalized Dosing

Florida State University

NCT05916417

RECRUITING Phase 2 60 participants

Pimavanserin for Insomnia in Veterans With PTSD

VA Office of Research and Development

NCT05441280

RECRUITING NA 50 participants

Mechanisms Underlying Efficacy of Prolonged Exposure

Massachusetts General Hospital

NCT05788302

RECRUITING Phase 1 50 participants

Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response

Yale University

NCT05915013

RECRUITING Phase 2 42 participants

Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder

Stanford University

NCT06577636

RECRUITING NA 40 participants

Exploring Virtual Reality Adventure Training Exergaming

The University of Texas at Arlington

NCT05563805

RECRUITING Phase 2 40 participants

Determining the Potential for Efficacy of OTX-601 in Reducing PTSD Symptoms

Oui Therapeutics

NCT07316088

RECRUITING Phase 2 40 participants

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

Stephen Robert Marder

NCT05790239

RECRUITING NA 40 participants

Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder

Wayne State University

NCT06740487

RECRUITING NA 30 participants

Targeting the Default Mode Network: A TMS-fMRI Study

Allyson Rosen

NCT05646732

RECRUITING NA 30 participants

Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI

The University of Texas Health Science Center at San Antonio

NCT07351305

RECRUITING Phase 2 30 participants

The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects

Yale University

NCT05786066

RECRUITING NA 20 participants

Open Trial of Trauma-focused Psychodynamic Psychotherapy for People Living With HIV and PTSD

Montefiore Medical Center

NCT05929911

RECRUITING NA 20 participants

Innovative Multimodal and Attention Training to Improve Emotion Communication in Veterans With TBI and PTSD

VA Office of Research and Development

NCT05478759

RECRUITING NA 20 participants

eTMS for Veterans and First Responders With PTSD

Virginia Polytechnic Institute and State University

NCT06294106

RECRUITING NA 20 participants

Brief Treatment for Trauma Nightmares in Trauma-exposed Adults With Bipolar Disorder

University of Tul

NCT02242110

RECRUITING Phase 3 20 participants

MDMA-assisted Massed Prolonged Exposure for PTSD

Healing Breakthrough

NCT06117306

RECRUITING Phase 4 20 participants

An Open Label Pilot Study of IV Brexanolone for the Treatment of Post-Traumatic Stress Disorder

Donald Jeffrey Newport

NCT05254405

RECRUITING Phase 2 18 participants

MDMA for AUD/PTSD Comorbidity

Carolina L Haass-Koffler

NCT05943665

RECRUITING Early Phase 1 6 participants

Responsive Neurostimulation for Post-Traumatic Stress Disorder

VA Greater Los Angeles Healthcare System

NCT04152993

ACTIVE NOT RECRUITING NA 410 participants

Stellate Ganglion Block for PTSD

VA Office of Research and Development

NCT05169190

ACTIVE NOT RECRUITING NA 250 participants

Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals

Massachusetts General Hospital

NCT01075672

ACTIVE NOT RECRUITING NA 191 participants

Efficacy of Virtual Warrior Renew Therapy for Veterans Who Experienced Military Sexual Trauma

Seattle Institute for Biomedical and Clinical Research

NCT05776719

ACTIVE NOT RECRUITING NA 80 participants

Testing the Effectiveness of a Therapist-Assisted Self-Management Program for Veterans Who Finished PTSD Therapy

VA Office of Research and Development

NCT05797441

ACTIVE NOT RECRUITING NA 70 participants

Web-administered STAIR for Patients on Behavioral Health Waitlists

Boston Medical Center

NCT06431022

ACTIVE NOT RECRUITING NA 40 participants

MOSAIC (MOthers' AdvocateS In the Community) for Pregnant Women and Mothers of Children Under 5 With Experience of Intimate Partner Violence

Michigan State University

NCT05106361

ACTIVE NOT RECRUITING NA 40 participants

An Intervention to Enhance Well-Being in Trauma Exposed New Mothers

Wayne State University

NCT05474534

ACTIVE NOT RECRUITING NA 30 participants

TMS for PTSD and Blood Pressure

Lifespan

NCT05512143

ACTIVE NOT RECRUITING Phase 1 20 participants

A Study of Psilocybin for PTSD

Johns Hopkins University

NCT06407635

ACTIVE NOT RECRUITING NA 20 participants

An Adjunctive Neurofeedback Training Program to Enhance Wellness Among Trauma-Exposed Postpartum Mothers

Wayne State University

NCT06054412

ACTIVE NOT RECRUITING NA 9 participants

Targeted Plasticity Therapy for Posttraumatic Stress Disorder

Baylor Research Institute

NCT04064762

ACTIVE NOT RECRUITING NA 8 participants

Rare Group Problem Management Plus

Children's National Research Institute

NCT06548022

ACTIVE NOT RECRUITING Phase 2 1 participants

Pilot rTMS for AUD+mTBI

VA Office of Research and Development

NCT03995173

COMPLETED 4,219 participants

Long Term Health Outcomes of Women Veterans' Service During the Vietnam Era

VA Office of Research and Development

NCT00958061

COMPLETED 4,193 participants

National Child Traumatic Stress Network (NCTSN) Quality Improvement Initiative Database

Hugo W. Moser Research Institute at Kennedy Krieger

NCT01591694

COMPLETED 1,431 participants

Evaluating the Effects of Stress in Pregnancy

Emory University

NCT00525226

COMPLETED NA 1,268 participants

Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking

University of New Hampshire

NCT03488927

COMPLETED NA 528 participants

Remotely Resolving Psychological Stress (Remote RePS)

University of California, San Francisco

NCT03196999

COMPLETED Phase 3 300 participants

The Trauma Recovery and Empowerment Model for Treating Post-Traumatic Stress Disorder in Women

Dartmouth-Hitchcock Medical Center

NCT00183716

COMPLETED NA 291 participants

Effectiveness of Peer-Delivered Trauma-Specific Treatment

University of New Mexi

NCT02081417

COMPLETED NA 274 participants

Cognitive-Behavioral Conjoint Therapy (CBCT) Project

VA Office of Research and Development

NCT02720016

COMPLETED Phase 2 245 participants

ALTO-100 in MDD and/or PTSD

Alto Neuroscience

NCT05117632

COMPLETED Phase 2 212 participants

A Phase 2b Study of BNC210 Tablet Formulation in Adults With Post-Traumatic Stress Disorder (PTSD)

Bionomics Limited

NCT04951076

COMPLETED NA 206 participants

The Family of Heroes: an Evaluation of an Online Educational Tool

Department of Veterans Affairs, New Jersey

NCT01554839

COMPLETED NA 200 participants

PTSD Training for PCPs in a Virtual World

San Francisco Veterans Affairs Medical Center

NCT03898271

COMPLETED NA 200 participants

A Randomized Controlled Trial of Meditation Compared to Exposure Therapy and Education Control on PTSD in Veterans

United States Department of Defense

NCT01865123

COMPLETED NA 180 participants

Examination of Glutamate and mGluR5 in Psychiatric Disorders

Yale University

NCT02727972

COMPLETED NA 178 participants

Brief Peer Supported webSTAIR Compared to Enhanced Wait List

Palo Alto Veterans Institute for Research

NCT04286165

COMPLETED NA 170 participants

Quantifying the Efficacy and Role of Service Dogs for Military Veterans With PTSD

University of Arizona

NCT03245814

← Previous Page 2 of 3 Next →

Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 22
Phase 3 8
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Post Traumatic Stress Disorder Trial Landscape

146 indexed Post Traumatic Stress Disorder studies · 71 recruiting (49%).

Phase mix: 13 late (III/IV) vs 30 early (I/II).

Top sponsor: VA Office of Research and Development (19 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Post Traumatic Stress Disorder?

PlainTrial tracks 146 US clinical trials for Post Traumatic Stress Disorder, of which 71 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Post Traumatic Stress Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.