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Post Traumatic Stress Disorder: early-phase trial registry
110 of 265 indexed Post Traumatic Stress Disorder trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #37 of 28,707 conditions by registered trial count.
265 US clinical trials · 110 currently recruiting · #37 of 28,707 conditions by registered trial count
Post Traumatic Stress Disorder: 265 US clinical trials tracked, 110 recruiting.
Post Traumatic Stress Disorder is the subject of 265 registered US clinical trials on ClinicalTrials.gov, 110 of them currently open to new participants. 22 are in Phase 3-4 (later-stage) and 46 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 45 of these trials.
Enrollment posture brief
Registry condition post-traumatic-stress-disorder
OPEN 110 | RECR 42% | LATE 22 | EARLY 46 | RANK #37 | SPON 45
Volume-matched condition peers
Nearest open-share peer: Glaucoma (41% recruiting · 94 trials)
Post Traumatic Stress Disorder lists 110 open slots (42% of 265 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Post Traumatic Stress Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Post Traumatic Stress Disorder is recruiting above its size-band peers.
110 of 265 indexed trials (41.5%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Post Traumatic Stress Disorder research.
VA Office of Research and Development accounts for 45 of 265 trials (17%). 130 distinct sponsors appear on at least one study for this condition label.
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Typical Post Traumatic Stress Disorder enrolment sits around 81 participants.
Median target enrolment is 81 among the 263 trials that report a genuine target (sentinel values excluded). 149 of those (56.7%) plan for fewer than 100 participants.
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Post Traumatic Stress Disorder research is mostly interventional.
250 interventional and 15 observational studies make up this index (94.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
265 total, page 2 of 6
Imaging SV2A in Mood Disorders
Yale University
NCT02734602
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
University of California, San Diego
NCT06273527
Evaluation of the PE Coach Mobile Application Among Veterans With PTSD
VA Office of Research and Development
NCT04959695
Psychotherapy Effects on Reward Processing in PTSD
University of Texas at Austin
NCT06096740
Cognitive Control Training for Extinction in PTSD
VA Office of Research and Development
NCT06629064
Lofexidine Combined With Buprenorphine for Reducing Symptoms of PTSD and OU Relapse in Veterans
Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
NCT04360681
Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI
NYU Langone Health
NCT04550377
General Psychological Distress, PTSD, and Co-Morbidities in Healthcare Workers Consequent to COVID-19
Weill Medical College of Cornell University
NCT04626050
Sympathetic Overactivity in Post-traumatic Stress Disorder
Emory University
NCT01627301
A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation
University of Pennsylvania
NCT06234969
Intensive Multi-Couple Therapy for PTSD Versus Relationship Education in Military Couples
Penn State University
NCT06047691
Effects of Games on Memory Reconsolidation and Trauma Symptoms
University of Texas at Austin
NCT06129435
Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa
Boston University Charles River Campus
NCT05624931
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
Yale University
NCT01730781
rTMS-augmented Written Exposure Therapy for PTSD
VA Office of Research and Development
NCT05149534
Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.
Massachusetts General Hospital
NCT07079761
Improving Sleep in Veterans With the Polytrauma Clinical Triad
VA Office of Research and Development
NCT06477796
Amygdala Memory Enhancement
Washington University School of Medicine
NCT05065450
The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans
Children's Hospital Los Angeles
NCT06218381
Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder
NYU Langone Health
NCT05391971
Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language Learners
University of Michigan
NCT06324383
Brain Health & Wellness Classes for Veterans With Traumatic Brain Injury
East Bay Institute for Research and Education
NCT06150196
Randomized Trial of Tele Vs. Clinic TF-CBT in Puerto Rico
Medical University of South Carolina
NCT06332209
Determining the Right Acupuncture for Good Recovery Over Neuropsychiatric Trauma
Paul Crawford
NCT05516862
Mitigating PTSD-CUD After Sexual Assault
University of Nevada, Las Vegas
NCT05989841
Disrupting Fear-based Memory Consolidation
Emory University
NCT05560113
Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms
University of New Mexi
NCT06449326
TMS-fNIRS Personalized Dosing
Florida State University
NCT05916417
Pimavanserin for Insomnia in Veterans With PTSD
VA Office of Research and Development
NCT05441280
Trauma Screening/Referral and Interpersonal Violence Prevention for Women with Substance Use Disorders
Clemson University
NCT06608979
CIH Stepped Care for Co-occurring Chronic Pain and PTSD
University of Washington
NCT06219408
Dose Optimization of MDMA-Assisted Therapy for PTSD
Bronx VA Medical Center
NCT06418178
Resilient Roots: Supporting Youth and Families
University of Rochester
NCT06535516
Biomolecular Characteristics of Reminder-Focused Positive-Psychiatry
University of California, Los Angeles
NCT04529031
Mechanisms Underlying Efficacy of Prolonged Exposure
Massachusetts General Hospital
NCT05788302
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
Yale University
NCT05915013
Mechanisms Underlying the Efficacy of Prolonged Exposure
VA Boston Healthcare System
NCT05663151
Biomarkers in the Retina for Prognosticating Mental Health Treatments
VA Puget Sound Health Care System
NCT06363968
Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder
Stanford University
NCT06577636
Exploring Virtual Reality Adventure Training Exergaming
The University of Texas at Arlington
NCT05563805
Determining the Potential for Efficacy of OTX-601 in Reducing PTSD Symptoms
Oui Therapeutics
NCT07316088
MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder
Stephen Robert Marder
NCT05790239
Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder
Wayne State University
NCT06740487
Integrated CBT to Improve Functioning in Veterans With Anxiety and Substance Use
VA Office of Research and Development
NCT04871100
Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)
Johns Hopkins University
NCT06989957
Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms
Walter Reed National Military Medical Center
NCT05414708
Repurposing Low-Dose Clonidine for PTSD in Veterans
Wake Forest University Health Sciences
NCT04877093
Targeting the Default Mode Network: A TMS-fMRI Study
Allyson Rosen
NCT05646732
Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI
The University of Texas Health Science Center at San Antonio
NCT07351305
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Yale University
NCT05786066
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 31 |
| Phase 3 | 11 |
| Phase 4 | 11 |
Top Sponsors
Named interventions
Most-linked intervention names on Post Traumatic Stress Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Post Traumatic Stress Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Post Traumatic Stress Disorder page
265 registered trials, 110 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 110 Post Traumatic Stress Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Post Traumatic Stress Disorder trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Post Traumatic Stress Disorder condition card totals 265 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.