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NCT06273527 · ClinicalTrials.gov registry record · Phase 2
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
A Phase 2 study of Depression and Post Traumatic Stress Disorder, sponsored by University of California, San Diego.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 128
- Enrollment target
- 1
- Study location
NCT06273527: Recruiting Phase 2 study of Depression and Post Traumatic Stress Disorder, sponsored by University of California, San Diego.
NCT06273527 is a Phase 2 study of Depression and Post Traumatic Stress Disorder that is actively recruiting participants, run by University of California, San Diego. The registered enrollment target is 128 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06273527, a Phase 2 study of Depression and Post Traumatic Stress Disorder, is actively recruiting participants, sponsored by University of California, San Diego.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 128 participants
- Enrollment target
- 1
- Study location
Study Summary
The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.
Primary Outcome
Span Working Memory Score. Scores are calculated based on memory accuracy total points across all trials, with higher scores indicating better performance. This change is expected to be significantly higher for the COGENT group than the Sham group.
Conditions Studied
Interventions
- BEHAVIORAL COGENT
- OTHER Sham Program
Study Locations (1)
California
- UC San Diego - San Diego
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 128 participants |
| Start Date | 2024-10-01 |
| Est. Completion | 2027-08-01 |
| Phase | Phase 2 |
What NCT06273527 shows while recruiting
NCT06273527 is an interventional study that assigns participants to a tested intervention. The registered 128 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (84% lower).
The record links to 3 conditions, with Depression appearing as the primary indexed condition, and to 2 interventions - of which COGENT is the first listed.
NCT06273527 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06273527 about?
NCT06273527 is a clinical study titled "Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)". The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program th...
What is the current status of trial NCT06273527?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 128 participants. The study started on 2024-10-01. Estimated completion is 2027-08-01.
What conditions does trial NCT06273527 study?
This clinical trial studies the following conditions: Depression, Post Traumatic Stress Disorder, Anxiety Disorders.
What interventions are being tested in trial NCT06273527?
The interventions under investigation include: COGENT (BEHAVIORAL), Sham Program (OTHER).
Who is sponsoring clinical trial NCT06273527?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06273527 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06273527's enrollment target sits among peer trials
128 288th of 679 higher than 391 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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