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NCT05149534 · ClinicalTrials.gov registry record · NA

rTMS-augmented Written Exposure Therapy for PTSD

A NA study of Post Traumatic Stress Disorder, sponsored by VA Office of Research and Development.

Recruiting
Registry status
NA
Development phase
98
Enrollment target
1
Study location

NCT05149534 is a NA study of Post Traumatic Stress Disorder that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 98 participants, below the 1,116-participant average among 144 other Post Traumatic Stress Disorder trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05149534, a NA study of Post Traumatic Stress Disorder, is actively recruiting participants, sponsored by VA Office of Research and Development.

RECRUITING
Registry status
NA
Development phase
98 participants
Enrollment target
1
Study location

Study Summary

Post-traumatic stress disorder (PTSD) is prevalent and represents a high healthcare burden among Veterans. Repetitive transcranial magnetic stimulation (rTMS) is a brain-based therapy that may be effective for treating PTSD. The theorized mechanism of rTMS is enhancement of emotional flexibility via the dorsolateral prefrontal cortex node of the brain's cognitive control network. Given this mechanism of action, adding rTMS to an evidence-based psychotherapy (EBP) for PTSD may enhance treatment effects. Written exposure therapy (WET) is a brief EBP for PTSD found to reduce attrition compared to lengthier first line treatments. In this study, the investigators will determine if active rTMS added to WET compared with sham rTMS added to WET results in improved PTSD outcomes. The investigators will also determine if emotional flexibility is a mechanism of symptom improvement. This work will improve upon PTSD intervention and inform the mechanism of treatment effectiveness for Veterans suffering from PTSD.

Conditions Studied

Post Traumatic Stress Disorder

Interventions

  • BEHAVIORAL Written Exposure Therapy
  • DEVICE repetitive transcranial magnetic stimulation

Study Locations (1)

Texas

  • Central Texas Veterans Health Care System, Temple, TX - Temple

Trial Details

FieldValue
Enrollment Target 98 participants
Start Date 2022-01-03
Est. Completion 2027-01-29
Phase NA

Sponsor

VA Office of Research and Development

1,668 total trials

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What the Registry Record Tells You About NCT05149534

The ClinicalTrials.gov registry entry for NCT05149534 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 98 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,116-participant average among 144 other Post Traumatic Stress Disorder trials with a reported enrollment target (91% lower). The listed sponsor is VA Office of Research and Development, which has 1,668 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Post Traumatic Stress Disorder appearing as the primary indexed condition, and to 2 interventions - of which Written Exposure Therapy is the first listed.

NCT05149534 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT05149534 about?

NCT05149534 is a clinical study titled "rTMS-augmented Written Exposure Therapy for PTSD". Post-traumatic stress disorder (PTSD) is prevalent and represents a high healthcare burden among Veterans. Repetitive transcranial magnetic stimulation (rTMS) is a brain-based therapy that may be effective for treating PTSD. The theorized mechanism of rTMS is enhancement of emotional flexibility via...

What is the current status of trial NCT05149534?

This trial is currently recruiting. It is a NA study. The enrollment target is 98 participants. The study started on 2022-01-03. Estimated completion is 2027-01-29.

What conditions does trial NCT05149534 study?

This clinical trial studies the following conditions: Post Traumatic Stress Disorder.

What interventions are being tested in trial NCT05149534?

The interventions under investigation include: Written Exposure Therapy (BEHAVIORAL), repetitive transcranial magnetic stimulation (DEVICE).

Who is sponsoring clinical trial NCT05149534?

This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05149534 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.