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NCT05560113 · ClinicalTrials.gov registry record · NA
Disrupting Fear-based Memory Consolidation
A NA study of Post Traumatic Stress Disorder, sponsored by Emory University.
- Recruiting
- Registry status
- NA
- Development phase
- 66
- Enrollment target
- 2
- Study locations
NCT05560113: Recruiting NA study of Post Traumatic Stress Disorder, sponsored by Emory University.
NCT05560113 is a NA study of Post Traumatic Stress Disorder that is actively recruiting participants, run by Emory University. The registered enrollment target is 66 participants, below the 664-participant average among 262 other Post Traumatic Stress Disorder trials with a reported enrollment target (90% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05560113, a NA study of Post Traumatic Stress Disorder, is actively recruiting participants, sponsored by Emory University.
- RECRUITING
- Registry status
- NA
- Development phase
- 66 participants
- Enrollment target
- 2
- Study locations
Study Summary
This project represents a unique collaborative opportunity to pursue the essential proof-of-principle demonstration that non-invasive interference of sensory cortical memory consolidation shortly after an emotional experience can attenuate the cued fear response and potentially reduce the risk of developing post-traumatic stress disorder (PTSD). If successful, the study results would anchor a potential advance in the treatment of patients after a traumatic event and seed future animal and clinical studies of emotional sensory cortical memory consolidation to reduce the prevalence and negative sequelae of PTSD.
Primary Outcome
Preprocessing of neuroimaging data will be conducted using fMRI prep. Pre-processed neuroimaging data will undergo first and second level modeling in Statistical Parametric Mapping. First level analysis include an event-related model with the onset and duration of each event included for each condition, and motion included as a regressor. A high-pass filter of 128s will be applied to account for low-frequency drifts. Amygdala regions of interest (ROIs) will be defined anatomically using Californ
Conditions Studied
Interventions
- OTHER Continuous theta burst stimulation (cTBS)
- OTHER Sham continuous theta burst stimulation (cTBS)
Study Locations (2)
Georgia
- Emory Rehabilitation Hospital - Atlanta
- Emory University Hospital - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2022-11-28 |
| Est. Completion | 2028-12 |
| Phase | NA |
What NCT05560113 shows while recruiting
NCT05560113 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, below the 664-participant average among 262 other Post Traumatic Stress Disorder trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Post Traumatic Stress Disorder appearing as the primary indexed condition, and to 2 interventions - of which Continuous theta burst stimulation (cTBS) is the first listed.
NCT05560113 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT05560113 about?
NCT05560113 is a clinical study titled "Disrupting Fear-based Memory Consolidation". This project represents a unique collaborative opportunity to pursue the essential proof-of-principle demonstration that non-invasive interference of sensory cortical memory consolidation shortly after an emotional experience can attenuate the cued fear response and potentially reduce the risk of de...
What is the current status of trial NCT05560113?
This trial is currently recruiting. It is a NA study. The enrollment target is 66 participants. The study started on 2022-11-28. Estimated completion is 2028-12.
What conditions does trial NCT05560113 study?
This clinical trial studies the following conditions: Post Traumatic Stress Disorder.
What interventions are being tested in trial NCT05560113?
The interventions under investigation include: Continuous theta burst stimulation (cTBS) (OTHER), Sham continuous theta burst stimulation (cTBS) (OTHER).
Who is sponsoring clinical trial NCT05560113?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05560113 being conducted?
This trial has 2 study locations across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Post Traumatic Stress Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05560113's enrollment target sits among peer trials
66 155th of 262 higher than 108 of 262 other Post Traumatic Stress Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Post Traumatic Stress Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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