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NCT05441280 · ClinicalTrials.gov registry record · Phase 2
Pimavanserin for Insomnia in Veterans With PTSD
A Phase 2 study of Post Traumatic Stress Disorder and Insomnia, sponsored by VA Office of Research and Development.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT05441280: Recruiting Phase 2 study of Post Traumatic Stress Disorder and Insomnia, sponsored by VA Office of Research and Development.
NCT05441280 is a Phase 2 study of Post Traumatic Stress Disorder and Insomnia that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 60 participants, below the 664-participant average among 262 other Post Traumatic Stress Disorder trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05441280, a Phase 2 study of Post Traumatic Stress Disorder and Insomnia, is actively recruiting participants, sponsored by VA Office of Research and Development.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a preliminary randomized, double-blind, placebo-controlled trial comparing pimavanserin 34mg at bedtime vs. placebo for the treatment of insomnia associated with post-traumatic stress disorder.
Primary Outcome
Mean change in ISI total score at 8-weeks in active vs. placebo groups
Conditions Studied
Interventions
- OTHER Placebo
- DRUG pimavanserin
Study Locations (1)
Texas
- Michael E. DeBakey VA Medical Center, Houston, TX - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2023-12-28 |
| Est. Completion | 2027-07-12 |
| Phase | Phase 2 |
What NCT05441280 shows while recruiting
NCT05441280 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 664-participant average among 262 other Post Traumatic Stress Disorder trials with a reported enrollment target (91% lower).
The record links to 2 conditions, with Post Traumatic Stress Disorder appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05441280 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05441280 about?
NCT05441280 is a clinical study titled "Pimavanserin for Insomnia in Veterans With PTSD". This is a preliminary randomized, double-blind, placebo-controlled trial comparing pimavanserin 34mg at bedtime vs. placebo for the treatment of insomnia associated with post-traumatic stress disorder.
What is the current status of trial NCT05441280?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2023-12-28. Estimated completion is 2027-07-12.
What conditions does trial NCT05441280 study?
This clinical trial studies the following conditions: Post Traumatic Stress Disorder, Insomnia.
What interventions are being tested in trial NCT05441280?
The interventions under investigation include: Placebo (OTHER), pimavanserin (DRUG).
Who is sponsoring clinical trial NCT05441280?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05441280 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Post Traumatic Stress Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05441280's enrollment target sits among peer trials
60 160th of 262 higher than 96 of 262 other Post Traumatic Stress Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Post Traumatic Stress Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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