Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Glaucoma

Open-data reference.

94 US clinical trials · 39 currently recruiting

Active & Recent Trials

RECRUITING NA 60,200 participants

Village-Integrated Eye Worker Trial II

University of California, San Francis

NCT03752840

RECRUITING 5,000 participants

Novel Glaucoma Diagnostics

Wills Eye

NCT00286637

RECRUITING NA 2,000 participants

The Glaucoma and Retinopathy Screening Study

Massachusetts Eye and Ear Infirmary

NCT06882356

RECRUITING NA 1,800 participants

Implementing AI-based Glaucoma Screening Within Federally Qualified Health Centers

University of Alabama at Birmingham

NCT06629649

RECRUITING NA 900 participants

Michigan Screening and Intervention for Glaucoma and Eye Health Through Telemedicine (SIGHT) 2

University of Michigan

NCT06934577

RECRUITING Phase 2 610 participants

Phase 2/Phase 3 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

Glaukos Corporation

NCT07075718

RECRUITING NA 500 participants

Stem Cell Ophthalmology Treatment Study II

MD Stem Cells

NCT03011541

RECRUITING Phase 3 400 participants

Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhine)

SpyGlass Pharma

NCT07218783

RECRUITING Phase 3 400 participants

Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhone)

SpyGlass Pharma

NCT07218796

RECRUITING NA 300 participants

Comparison of Intraocular Pressure Measurement With the Novel TonoVera Device With Other Commonly Used Devices

State University of New York at Buffalo

NCT05523622

RECRUITING NA 245 participants

Glaukos® iStent Infinite Trabecular Micro-Bypass System in Subjects With Mild to Moderate Primary Open-angle Glaucoma

Glaukos Corporation

NCT06057051

RECRUITING NA 243 participants

A Trial of Hydrus Microstent Versus Goniotomy

Massachusetts Eye and Ear Infirmary

NCT06289491

RECRUITING Phase 2 228 participants

Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults With Primary Open Angle Glaucoma or Ocular Hypertension

Bausch & Lomb Incorporated

NCT07168902

RECRUITING NA 226 participants

Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial

University of Pennsylvania

NCT05924477

RECRUITING NA 200 participants

Automated Applanation Tonometry - Updated

Duke University

NCT07298356

RECRUITING 180 participants

Data Gathering for A10900

Optos

NCT07149740

RECRUITING 160 participants

Functional and Structural Imaging for Glaucoma

Oregon Health and Science University

NCT01957267

RECRUITING 150 participants

To Study Ocular Outflow Dynamics of the Eye Using Intraoperative Tonographic Biometry and Assess Its Predictive Value in Improving Postoperative Outcomes.

The New York Eye & Ear Infirmary

NCT07425496

RECRUITING NA 150 participants

Ocular Blood Flow Imaging for Glaucoma Assessment

University of Maryland, Baltimore

NCT05726058

RECRUITING Phase 3 142 participants

Pilocarpine Use After Kahook Goniotomy

Montefiore Medical Center

NCT03933631

RECRUITING 125 participants

24-hour Wear Performance and Safety Study of Smartlens miLens Contact Lens for IOP Monitoring

Smartlens

NCT06689696

RECRUITING Phase 4 90 participants

Retinal Blood Flow and Autoregulation

University of Maryland, Baltimore

NCT05344274

RECRUITING 75 participants

Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications

University of California, Los Angeles

NCT04354545

RECRUITING 60 participants

A Prospective Study on the Efficacy of Direct Selective Laser Trabeculoplasty (DSLT) in Achieving >20% Intraocular Pressure (IOP) Reduction Without Medications at 6 Months in Naive, Untreated Glaucoma Patients

Brian Shafer

NCT07076303

RECRUITING NA 60 participants

Hyperbaric Oxygen Therapy for Optic Neuropathies

Stanford University

NCT06128720

RECRUITING NA 60 participants

Perimetric Testing With Virtual Reality

Envision Health Technologies

NCT06549010

RECRUITING 60 participants

Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy

University of Maryland, Baltimore

NCT06993597

RECRUITING NA 60 participants

Community Based Treatment for (ComBaT) Glaucoma

University of Michigan

NCT06124521

RECRUITING Phase 1 52 participants

Topical Insulin for Glaucoma

Stanford University

NCT05206877

RECRUITING NA 50 participants

Tolerability of an Anesthesia-free Tonometer Tip

Duke University

NCT06585423

RECRUITING NA 48 participants

Glaucoma Laser Assessment of Stability and Sustainability

Twin Cities Eye Consultants

NCT06963684

RECRUITING 46 participants

Eye Pressure Lowering Surgery

Oregon Health and Science University

NCT01931904

RECRUITING NA 45 participants

Electrical Stimulation for the Treatment of Glaucoma

Stanford University

NCT05626491

RECRUITING NA 40 participants

Electrical Stimulation for the Treatment of Optic Neuropathies

Stanford University

NCT05626426

RECRUITING NA 40 participants

The Role of Music in Enhancing Attention During Visual Field Exams for Pediatric Glaucoma Patients

Johns Hopkins University

NCT06971588

RECRUITING Phase 4 35 participants

Evaluating Injection With the Use of Brimonidine Tartrate Ophthalmic 0.025% on Patients Using Netarsudil 0.02%/Latanoprost 0.005% to Treat Glaucoma

Insight Eyecare Specialties, Inc. dba Vision Source Eyecare,

NCT07209410

RECRUITING 30 participants

Optimize Pediatric OCT Imaging

Duke University

NCT06139523

RECRUITING NA 30 participants

Electrical Stimulation for Vision Neuroenhancement in Glaucoma

Stanford University

NCT06685211

RECRUITING Phase 4 20 participants

Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication Use

University of Miami

NCT07217678

ACTIVE NOT RECRUITING NA 975 participants

Evaluate the Safety and Effectiveness of iSTAR Medical's MINIject™ Implant for Lowering Intraocular Pressure (IOP) in Subjects With Primary Open-angle Glaucoma.

iSTAR Medical

NCT05024695

ACTIVE NOT RECRUITING NA 749 participants

Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT)

Columbia University

NCT04271709

ACTIVE NOT RECRUITING NA 358 participants

iStent Inject New Enrollment Post-Approval Study

Glaukos Corporation

NCT04624698

ACTIVE NOT RECRUITING 300 participants

A Real-World Study of Interventional Clinical Outcomes in Patients With Open Angle Glaucoma and Other Chronic Eye Diseases

Interstat

NCT07216677

ACTIVE NOT RECRUITING Phase 1 201 participants

Evaluation of the Bimatoprost Implant System Used in Combination With the SpyGlass Intraocular Lens Compared to Timolol Ophthalmic Solution

SpyGlass Pharma

NCT06120842

ACTIVE NOT RECRUITING Phase 1 120 participants

Safety Assessment of T4090 Eye Drops in Ocular Hypertensive or Glaucomatous Patients.

Laboratoires Thea

NCT05389267

ACTIVE NOT RECRUITING 116 participants

Anterior Segment Optical Coherence Tomography Microstent Positioning

University of Utah

NCT06666751

ACTIVE NOT RECRUITING 100 participants

Visual Field Analysis With Artificial Intelligence

Sight Intelligence Engineering Corporation

NCT06920290

ACTIVE NOT RECRUITING Phase 2 54 participants

Study of NT-501 Encapsulated Cell Therapy for Glaucoma Neuroprotection and Vision Restoration

Stanford University

NCT02862938

ACTIVE NOT RECRUITING Phase 2 30 participants

Dual Intravitreal Implantation of NT-501 Encapsulated Cell Therapy for Glaucoma

Stanford University

NCT04577300

ACTIVE NOT RECRUITING Early Phase 1 5 participants

A Study of Yutiq Steroid Insert During Glaucoma Tube Implant Surgery

Sanjay Asrani

NCT04918121

COMPLETED Phase 4 750 participants

Examining The Efficacy, Safety And Improved Tolerability Of Travoprost BAK Free Ophthalmic Solution (Travatan-Z) Compared To Prior Prostaglandin Therapy

Alcon Research

NCT00444665

COMPLETED Phase 3 684 participants

Efficacy and Safety Assessment of T4032 (Unpreserved Bimatoprost 0.01%) Versus Lumigan® 0.01% in Ocular Hypertensive or Glaucomatous Patients

Laboratoires Thea

NCT05397600

COMPLETED Phase 1 637 participants

Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt

Bausch & Lomb Incorporated

NCT03896633

COMPLETED Phase 3 432 participants

Safety and Efficacy Study of Brimonidine/Timolol Fixed Combination in Patients With Glaucoma or Ocular Hypertension

Allergan

NCT00652106

COMPLETED Phase 1 276 participants

Efficacy, Tolerability and Safety of RKI983 (0.05% & 0.10%) vs Xalatan in Patients With POAG or Ocular Hypertension

Novartis Pharmaceuticals

NCT00846989

COMPLETED Phase 4 266 participants

Bimatoprost 0.03% Versus Travoprost 0.004% in Patients Currently on Latanoprost 0.005%

Allergan

NCT00440011

COMPLETED Phase 4 242 participants

Primary Tube Versus Trabeculectomy Study

University of Miami

NCT00666237

COMPLETED 175 participants

Pigment Dispersion Syndrome With and Without Glaucoma

National Eye Institute (NEI)

NCT00001152

COMPLETED 174 participants

Chart Review of XEN 45 Gel Stent: Long Term Performance and Safety Assessment (XEN LT)

Allergan

NCT03868254

COMPLETED 160 participants

Will Listening to Music Make it Easier to Take a Visual Field Test?

Wills Eye

NCT01027039

COMPLETED Phase 1 144 participants

A Dose-Escalation Study Designed to Evaluate the Tolerability, Safety, Pharmacokinetics (PK), and Efficacy of Chronic Topical Ocular Application of INO-8875 in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma

Inotek Pharmaceuticals Corporation

NCT01123785

COMPLETED 119 participants

Macular Ganglion Cell Analysis (GCA) of the Cirrus HD-OCT in Glaucoma

Carl Zeiss Meditec

NCT01272102

COMPLETED Phase 2 119 participants

Ahmed Glaucoma Valve Surgery With Mitomycin-C

University of California, San Francis

NCT02805257

COMPLETED Phase 2 112 participants

A Safety and Efficacy Study of Fixed-Combination Bimatoprost and Brimonidine in Chronic Glaucoma or Ocular Hypertension

Allergan

NCT01863953

COMPLETED NA 107 participants

The eyeGuide: Improving Glaucoma Self-management With a Personalized Behavior Change Program

University of Michigan

NCT03159247

COMPLETED 100 participants

Testing Latest Version of NidekRS3000Adv

Doheny Image Reading Center

NCT03318705

COMPLETED NA 95 participants

Intraocular Pressure Control Following One Site Versus Two Site Combined Phacoemulsification/IOL And Trabeculectomy

Lahey Clinic

NCT00695747

COMPLETED 92 participants

Steroid Eyedrop Adherence After Trabeculectomy

Johns Hopkins University

NCT03402802

COMPLETED Phase 2 82 participants

Multiple Dose-escalation Study of AMA0076 in Patients With Ocular Hypertension or Primary Open-angle Glaucoma

Amakem

NCT01693315

COMPLETED NA 80 participants

Baerveldt 350 vs Ahmed ClearPath 250 for the Treatment of Glaucoma

State University of New York at Buffalo

NCT04542616

COMPLETED Phase 4 74 participants

AZARGA Transition Study in Taiwan for Patients With Uncontrolled Intraocular Pressure

Alcon Research

NCT01484951

COMPLETED Phase 1 60 participants

Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma

Dompé Farmaceutici S.p.A

NCT02855450

COMPLETED Phase 4 59 participants

Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance

Ohio State University

NCT04412096

COMPLETED Phase 4 58 participants

How Similar Are Changes to the Surface of the Eye When Two Different Glaucoma Eye Drops Are Used?

Wills Eye

NCT00798694

COMPLETED NA 57 participants

SDOCT-GMPE Software

Duke University

NCT02235454

COMPLETED Phase 2 57 participants

A Dose Evaluation Study for the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma

Mati Therapeutics

NCT01481051

COMPLETED 56 participants

Trusopt and Cosopt; Ocular Perfusion Pressure and Blood Flow: New Long-term Prospective Data

Indiana University

NCT01145898

COMPLETED 48 participants

Topcon 3D OCT-1000 Optical Coherence Tomography System

Topcon Medical Systems

NCT00792259

COMPLETED Phase 1 45 participants

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO5093151 in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT).

Hoffmann-La Roche

NCT02622334

COMPLETED NA 44 participants

Effect of Glaucoma Educators on Adherence to Prescribed Therapeutic Regimens in Glaucoma Patients

University of Colorado, Denver

NCT00454922

COMPLETED Phase 4 43 participants

Comparison of Combigan Two Times Daily (BID) Versus Simbrinza Three Times Daily (TID)

Cornerstone Health Care, PA

NCT02167035

COMPLETED 40 participants

Comparing the Effect of the Water Drinking Test on Intraocular Pressure

Wills Eye

NCT02001155

COMPLETED 35 participants

Aqueous Suppressant Versus Aqueous Outflow on Ocular Blood Flow

Indiana University

NCT01308788

COMPLETED Phase 2 30 participants

Circadian Rhythms of Aqueous Humor Dynamics in Humans

University of Nebraska

NCT00572936

COMPLETED NA 28 participants

Effects of a Single OMT on Intraocular Pressure (IOP) in Ocular Hypertenive or Glaucoma Suspect Subjects

University of Wisconsin, Madison

NCT01864642

COMPLETED Phase 2 24 participants

Lucentis Versus Mitomycin C During Glaucoma Surgery

Wills Eye

NCT00626782

COMPLETED NA 23 participants

The Effects of the Water Drinking Test on Intraocular Pressure

University of California, San Diego

NCT01507584

COMPLETED NA 21 participants

Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)

Massachusetts Eye and Ear Infirmary

NCT00824824

COMPLETED NA 20 participants

An App-based Instructional Platform to Improve Eye Drop Recall

University of California, San Francis

NCT06045390

COMPLETED NA 18 participants

A Study Using Transorbital Alternating Current Stimulation for People With Glaucoma

NYU Langone Health

NCT03188042

COMPLETED Early Phase 1 11 participants

Does Oral Acetaminophen Lower Intraocular Pressure?

Johns Hopkins University

NCT02366065

COMPLETED Phase 1 11 participants

Retinal Effects of Balance Goggles System in Glaucoma Balance Goggles System (BGS) in Patients With Glaucoma

Stanford University

NCT04035239

COMPLETED NA 2 participants

Adult Providing Access to the Visual Environment (PAVE) - Glaucoma Pilot

Vanderbilt University

NCT00338208

COMPLETED Phase 4

Efficacy of Bimatoprost 0.03% in Patients Who Are Low-Responders to Latanoprost

Innovative Medical

NCT00347841

Phase Distribution

PhaseTrial count
Early Phase 1 11
Phase 2 10
Phase 3 5
Phase 4 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Glaucoma Trial Landscape

ClinicalTrials.gov lists 94 US studies indexed under Glaucoma, and 39 of those are currently open to recruitment — roughly 41% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Glaucoma shows 16 late-stage studies (Phase 3 and Phase 4 combined) alongside 21 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Glaucoma is led by Stanford University with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 94 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Glaucoma?

PlainTrial tracks 94 US clinical trials for Glaucoma, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Glaucoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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