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Glaucoma
Open-data reference.
94 US clinical trials · 39 currently recruiting
Active & Recent Trials
Village-Integrated Eye Worker Trial II
University of California, San Francis
NCT03752840
Novel Glaucoma Diagnostics
Wills Eye
NCT00286637
The Glaucoma and Retinopathy Screening Study
Massachusetts Eye and Ear Infirmary
NCT06882356
Implementing AI-based Glaucoma Screening Within Federally Qualified Health Centers
University of Alabama at Birmingham
NCT06629649
Michigan Screening and Intervention for Glaucoma and Eye Health Through Telemedicine (SIGHT) 2
University of Michigan
NCT06934577
Phase 2/Phase 3 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
Glaukos Corporation
NCT07075718
Stem Cell Ophthalmology Treatment Study II
MD Stem Cells
NCT03011541
Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhine)
SpyGlass Pharma
NCT07218783
Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhone)
SpyGlass Pharma
NCT07218796
Comparison of Intraocular Pressure Measurement With the Novel TonoVera Device With Other Commonly Used Devices
State University of New York at Buffalo
NCT05523622
Glaukos® iStent Infinite Trabecular Micro-Bypass System in Subjects With Mild to Moderate Primary Open-angle Glaucoma
Glaukos Corporation
NCT06057051
A Trial of Hydrus Microstent Versus Goniotomy
Massachusetts Eye and Ear Infirmary
NCT06289491
Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults With Primary Open Angle Glaucoma or Ocular Hypertension
Bausch & Lomb Incorporated
NCT07168902
Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial
University of Pennsylvania
NCT05924477
Automated Applanation Tonometry - Updated
Duke University
NCT07298356
Data Gathering for A10900
Optos
NCT07149740
Functional and Structural Imaging for Glaucoma
Oregon Health and Science University
NCT01957267
To Study Ocular Outflow Dynamics of the Eye Using Intraoperative Tonographic Biometry and Assess Its Predictive Value in Improving Postoperative Outcomes.
The New York Eye & Ear Infirmary
NCT07425496
Ocular Blood Flow Imaging for Glaucoma Assessment
University of Maryland, Baltimore
NCT05726058
Pilocarpine Use After Kahook Goniotomy
Montefiore Medical Center
NCT03933631
24-hour Wear Performance and Safety Study of Smartlens miLens Contact Lens for IOP Monitoring
Smartlens
NCT06689696
Retinal Blood Flow and Autoregulation
University of Maryland, Baltimore
NCT05344274
Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications
University of California, Los Angeles
NCT04354545
A Prospective Study on the Efficacy of Direct Selective Laser Trabeculoplasty (DSLT) in Achieving >20% Intraocular Pressure (IOP) Reduction Without Medications at 6 Months in Naive, Untreated Glaucoma Patients
Brian Shafer
NCT07076303
Hyperbaric Oxygen Therapy for Optic Neuropathies
Stanford University
NCT06128720
Perimetric Testing With Virtual Reality
Envision Health Technologies
NCT06549010
Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy
University of Maryland, Baltimore
NCT06993597
Community Based Treatment for (ComBaT) Glaucoma
University of Michigan
NCT06124521
Topical Insulin for Glaucoma
Stanford University
NCT05206877
Tolerability of an Anesthesia-free Tonometer Tip
Duke University
NCT06585423
Glaucoma Laser Assessment of Stability and Sustainability
Twin Cities Eye Consultants
NCT06963684
Eye Pressure Lowering Surgery
Oregon Health and Science University
NCT01931904
Electrical Stimulation for the Treatment of Glaucoma
Stanford University
NCT05626491
Electrical Stimulation for the Treatment of Optic Neuropathies
Stanford University
NCT05626426
The Role of Music in Enhancing Attention During Visual Field Exams for Pediatric Glaucoma Patients
Johns Hopkins University
NCT06971588
Evaluating Injection With the Use of Brimonidine Tartrate Ophthalmic 0.025% on Patients Using Netarsudil 0.02%/Latanoprost 0.005% to Treat Glaucoma
Insight Eyecare Specialties, Inc. dba Vision Source Eyecare,
NCT07209410
Optimize Pediatric OCT Imaging
Duke University
NCT06139523
Electrical Stimulation for Vision Neuroenhancement in Glaucoma
Stanford University
NCT06685211
Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication Use
University of Miami
NCT07217678
Evaluate the Safety and Effectiveness of iSTAR Medical's MINIject™ Implant for Lowering Intraocular Pressure (IOP) in Subjects With Primary Open-angle Glaucoma.
iSTAR Medical
NCT05024695
Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT)
Columbia University
NCT04271709
iStent Inject New Enrollment Post-Approval Study
Glaukos Corporation
NCT04624698
A Real-World Study of Interventional Clinical Outcomes in Patients With Open Angle Glaucoma and Other Chronic Eye Diseases
Interstat
NCT07216677
Evaluation of the Bimatoprost Implant System Used in Combination With the SpyGlass Intraocular Lens Compared to Timolol Ophthalmic Solution
SpyGlass Pharma
NCT06120842
Safety Assessment of T4090 Eye Drops in Ocular Hypertensive or Glaucomatous Patients.
Laboratoires Thea
NCT05389267
Anterior Segment Optical Coherence Tomography Microstent Positioning
University of Utah
NCT06666751
Visual Field Analysis With Artificial Intelligence
Sight Intelligence Engineering Corporation
NCT06920290
Study of NT-501 Encapsulated Cell Therapy for Glaucoma Neuroprotection and Vision Restoration
Stanford University
NCT02862938
Dual Intravitreal Implantation of NT-501 Encapsulated Cell Therapy for Glaucoma
Stanford University
NCT04577300
A Study of Yutiq Steroid Insert During Glaucoma Tube Implant Surgery
Sanjay Asrani
NCT04918121
Examining The Efficacy, Safety And Improved Tolerability Of Travoprost BAK Free Ophthalmic Solution (Travatan-Z) Compared To Prior Prostaglandin Therapy
Alcon Research
NCT00444665
Efficacy and Safety Assessment of T4032 (Unpreserved Bimatoprost 0.01%) Versus Lumigan® 0.01% in Ocular Hypertensive or Glaucomatous Patients
Laboratoires Thea
NCT05397600
Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt
Bausch & Lomb Incorporated
NCT03896633
Safety and Efficacy Study of Brimonidine/Timolol Fixed Combination in Patients With Glaucoma or Ocular Hypertension
Allergan
NCT00652106
Efficacy, Tolerability and Safety of RKI983 (0.05% & 0.10%) vs Xalatan in Patients With POAG or Ocular Hypertension
Novartis Pharmaceuticals
NCT00846989
Bimatoprost 0.03% Versus Travoprost 0.004% in Patients Currently on Latanoprost 0.005%
Allergan
NCT00440011
Primary Tube Versus Trabeculectomy Study
University of Miami
NCT00666237
Pigment Dispersion Syndrome With and Without Glaucoma
National Eye Institute (NEI)
NCT00001152
Chart Review of XEN 45 Gel Stent: Long Term Performance and Safety Assessment (XEN LT)
Allergan
NCT03868254
Will Listening to Music Make it Easier to Take a Visual Field Test?
Wills Eye
NCT01027039
A Dose-Escalation Study Designed to Evaluate the Tolerability, Safety, Pharmacokinetics (PK), and Efficacy of Chronic Topical Ocular Application of INO-8875 in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma
Inotek Pharmaceuticals Corporation
NCT01123785
Macular Ganglion Cell Analysis (GCA) of the Cirrus HD-OCT in Glaucoma
Carl Zeiss Meditec
NCT01272102
Ahmed Glaucoma Valve Surgery With Mitomycin-C
University of California, San Francis
NCT02805257
A Safety and Efficacy Study of Fixed-Combination Bimatoprost and Brimonidine in Chronic Glaucoma or Ocular Hypertension
Allergan
NCT01863953
The eyeGuide: Improving Glaucoma Self-management With a Personalized Behavior Change Program
University of Michigan
NCT03159247
Testing Latest Version of NidekRS3000Adv
Doheny Image Reading Center
NCT03318705
Intraocular Pressure Control Following One Site Versus Two Site Combined Phacoemulsification/IOL And Trabeculectomy
Lahey Clinic
NCT00695747
Steroid Eyedrop Adherence After Trabeculectomy
Johns Hopkins University
NCT03402802
Multiple Dose-escalation Study of AMA0076 in Patients With Ocular Hypertension or Primary Open-angle Glaucoma
Amakem
NCT01693315
Baerveldt 350 vs Ahmed ClearPath 250 for the Treatment of Glaucoma
State University of New York at Buffalo
NCT04542616
AZARGA Transition Study in Taiwan for Patients With Uncontrolled Intraocular Pressure
Alcon Research
NCT01484951
Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma
Dompé Farmaceutici S.p.A
NCT02855450
Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance
Ohio State University
NCT04412096
How Similar Are Changes to the Surface of the Eye When Two Different Glaucoma Eye Drops Are Used?
Wills Eye
NCT00798694
SDOCT-GMPE Software
Duke University
NCT02235454
A Dose Evaluation Study for the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma
Mati Therapeutics
NCT01481051
Trusopt and Cosopt; Ocular Perfusion Pressure and Blood Flow: New Long-term Prospective Data
Indiana University
NCT01145898
Topcon 3D OCT-1000 Optical Coherence Tomography System
Topcon Medical Systems
NCT00792259
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO5093151 in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT).
Hoffmann-La Roche
NCT02622334
Effect of Glaucoma Educators on Adherence to Prescribed Therapeutic Regimens in Glaucoma Patients
University of Colorado, Denver
NCT00454922
Comparison of Combigan Two Times Daily (BID) Versus Simbrinza Three Times Daily (TID)
Cornerstone Health Care, PA
NCT02167035
Comparing the Effect of the Water Drinking Test on Intraocular Pressure
Wills Eye
NCT02001155
Aqueous Suppressant Versus Aqueous Outflow on Ocular Blood Flow
Indiana University
NCT01308788
Circadian Rhythms of Aqueous Humor Dynamics in Humans
University of Nebraska
NCT00572936
Effects of a Single OMT on Intraocular Pressure (IOP) in Ocular Hypertenive or Glaucoma Suspect Subjects
University of Wisconsin, Madison
NCT01864642
Lucentis Versus Mitomycin C During Glaucoma Surgery
Wills Eye
NCT00626782
The Effects of the Water Drinking Test on Intraocular Pressure
University of California, San Diego
NCT01507584
Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)
Massachusetts Eye and Ear Infirmary
NCT00824824
An App-based Instructional Platform to Improve Eye Drop Recall
University of California, San Francis
NCT06045390
A Study Using Transorbital Alternating Current Stimulation for People With Glaucoma
NYU Langone Health
NCT03188042
Does Oral Acetaminophen Lower Intraocular Pressure?
Johns Hopkins University
NCT02366065
Retinal Effects of Balance Goggles System in Glaucoma Balance Goggles System (BGS) in Patients With Glaucoma
Stanford University
NCT04035239
Adult Providing Access to the Visual Environment (PAVE) - Glaucoma Pilot
Vanderbilt University
NCT00338208
Efficacy of Bimatoprost 0.03% in Patients Who Are Low-Responders to Latanoprost
Innovative Medical
NCT00347841
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 11 |
| Phase 2 | 10 |
| Phase 3 | 5 |
| Phase 4 | 11 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Glaucoma Trial Landscape
ClinicalTrials.gov lists 94 US studies indexed under Glaucoma, and 39 of those are currently open to recruitment — roughly 41% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Glaucoma shows 16 late-stage studies (Phase 3 and Phase 4 combined) alongside 21 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Glaucoma is led by Stanford University with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 94 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Glaucoma?
PlainTrial tracks 94 US clinical trials for Glaucoma, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Glaucoma?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.