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NCT06418178 · ClinicalTrials.gov registry record · Phase 2

Dose Optimization of MDMA-Assisted Therapy for PTSD

A Phase 2 study of Posttraumatic Stress Disorder, sponsored by Bronx VA Medical Center.

Recruiting
Registry status
Phase 2
Development phase
60
Enrollment target
1
Study location

NCT06418178 is a Phase 2 study of Posttraumatic Stress Disorder that is actively recruiting participants, run by Bronx VA Medical Center. The registered enrollment target is 60 participants, below the 111-participant average among 117 other Posttraumatic Stress Disorder trials with a reported enrollment target (46% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06418178, a Phase 2 study of Posttraumatic Stress Disorder, is actively recruiting participants, sponsored by Bronx VA Medical Center.

RECRUITING
Registry status
Phase 2
Development phase
60 participants
Enrollment target
1
Study location

Study Summary

This open label, within-subjects dose optimization trial will investigate the optimal number of MDMA-Assisted Therapy treatment cycles (i.e., one MDMA session and three integration sessions) in a sample of U.S. veterans with PTSD. Participants will complete from one to five cycles of MDMA-AT.

Conditions Studied

Posttraumatic Stress Disorder

Interventions

  • BEHAVIORAL Psychotherapy
  • DRUG Midomafetamine

Study Locations (1)

New York

  • James J. Peters VA Medical Center - The Bronx

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2025-06-03
Est. Completion 2029-10
Phase Phase 2

Sponsor

Bronx VA Medical Center

13 total trials

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What the Registry Record Tells You About NCT06418178

The ClinicalTrials.gov registry entry for NCT06418178 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 111-participant average among 117 other Posttraumatic Stress Disorder trials with a reported enrollment target (46% lower). The listed sponsor is Bronx VA Medical Center, which has 13 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Posttraumatic Stress Disorder appearing as the primary indexed condition, and to 2 interventions - of which Psychotherapy is the first listed.

NCT06418178 reports 1 study location spanning 1 distinct geographic area - top geographies include New York.

Frequently Asked Questions

What is clinical trial NCT06418178 about?

NCT06418178 is a clinical study titled "Dose Optimization of MDMA-Assisted Therapy for PTSD". This open label, within-subjects dose optimization trial will investigate the optimal number of MDMA-Assisted Therapy treatment cycles (i.e., one MDMA session and three integration sessions) in a sample of U.S. veterans with PTSD. Participants will complete from one to five cycles of MDMA-AT.

What is the current status of trial NCT06418178?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2025-06-03. Estimated completion is 2029-10.

What conditions does trial NCT06418178 study?

This clinical trial studies the following conditions: Posttraumatic Stress Disorder.

What interventions are being tested in trial NCT06418178?

The interventions under investigation include: Psychotherapy (BEHAVIORAL), Midomafetamine (DRUG).

Who is sponsoring clinical trial NCT06418178?

This trial is sponsored by Bronx VA Medical Center, which has 13 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06418178 being conducted?

This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.