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NCT06989957 · ClinicalTrials.gov registry record · Phase 1

Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)

A Phase 1 study of Posttraumatic Stress Disorder, sponsored by Johns Hopkins University.

Recruiting
Registry status
Phase 1
Development phase
40
Enrollment target
1
Study location

NCT06989957 is a Phase 1 study of Posttraumatic Stress Disorder that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 40 participants, below the 112-participant average among 117 other Posttraumatic Stress Disorder trials with a reported enrollment target (64% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06989957, a Phase 1 study of Posttraumatic Stress Disorder, is actively recruiting participants, sponsored by Johns Hopkins University.

RECRUITING
Registry status
Phase 1
Development phase
40 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is to assess the safety and effectiveness of co-administered MDMA and psilocybin in military Veterans with a diagnosis of Posttraumatic Stress Disorder (PTSD). To apply or learn more, please view our website: https://hopkinspsychedelic.org/pamvet

Conditions Studied

Posttraumatic Stress Disorder

Interventions

  • DRUG Psilocybin
  • DRUG MDMA

Study Locations (1)

Maryland

  • Johns Hopkins Center for Psychedelic and Consciousness Research - Baltimore

Trial Details

FieldValue
Enrollment Target 40 participants
Start Date 2025-09-17
Est. Completion 2029-08
Phase Phase 1

Sponsor

Johns Hopkins University

1,448 total trials

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What the Registry Record Tells You About NCT06989957

The ClinicalTrials.gov registry entry for NCT06989957 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 112-participant average among 117 other Posttraumatic Stress Disorder trials with a reported enrollment target (64% lower). The listed sponsor is Johns Hopkins University, which has 1,448 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Posttraumatic Stress Disorder appearing as the primary indexed condition, and to 2 interventions - of which Psilocybin is the first listed.

NCT06989957 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.

Frequently Asked Questions

What is clinical trial NCT06989957 about?

NCT06989957 is a clinical study titled "Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)". The purpose of this study is to assess the safety and effectiveness of co-administered MDMA and psilocybin in military Veterans with a diagnosis of Posttraumatic Stress Disorder (PTSD). To apply or learn more, please view our website: https://hopkinspsychedelic.org/pamvet

What is the current status of trial NCT06989957?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2025-09-17. Estimated completion is 2029-08.

What conditions does trial NCT06989957 study?

This clinical trial studies the following conditions: Posttraumatic Stress Disorder.

What interventions are being tested in trial NCT06989957?

The interventions under investigation include: Psilocybin (DRUG), MDMA (DRUG).

Who is sponsoring clinical trial NCT06989957?

This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06989957 being conducted?

This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.