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ClinicalTrials.gov 71 recruiting now official registry

Post Traumatic Stress Disorder clinical trials

71 of 146 indexed Post Traumatic Stress Disorder trials are currently recruiting.

146 US clinical trials · 71 currently recruiting

Post Traumatic Stress Disorder is the subject of 146 registered US clinical trials on ClinicalTrials.gov, 71 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 30 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 19 of these trials.

The research picture

Post Traumatic Stress Disorder has 146 registered US clinical trials, 71 of them open to new participants right now, about 49% of the total.

71
recruiting participants now
49%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
19
top sponsor: VA Office of Research and Development
Phase 18Phase 222Phase 38Phase 45

Active & Recent Trials

146 total, page 1 of 3

RECRUITING NA 80,800 participants

Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress

Stanford University

NCT05701111

RECRUITING 50,000 participants

RIVER At Home Ketamine Protocols

RIVER Foundation

NCT06070766

RECRUITING Phase 2 800 participants

Department of Defense PTSD Adaptive Platform Trial - Master Protocol

Global Coalition for Adaptive Research

NCT05422612

RECRUITING NA 720 participants

Evaluation of the Parenting in the Moment Online Program for Forcibly Displaced Families

Arizona State University

NCT06548126

RECRUITING NA 676 participants

Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study

Johns Hopkins University

NCT07227337

RECRUITING NA 600 participants

CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos

Drexel University

NCT06139159

RECRUITING NA 600 participants

CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy

University of Texas at Austin

NCT05467683

RECRUITING NA 428 participants

Stepped Care for Posttraumatic Stress Disorder Study

Boston Medical Center

NCT06947538

RECRUITING NA 420 participants

A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD

United States Department of Defense

NCT06990191

RECRUITING NA 410 participants

Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers

University of Michigan

NCT05751473

RECRUITING NA 400 participants

Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

Duke University

NCT06538246

RECRUITING Phase 3 372 participants

Goal-Directed Sedation in Mechanically Ventilated Infants and Children

Vanderbilt University Medical Center

NCT04801589

RECRUITING NA 330 participants

Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD

The University of Texas at Dallas

NCT03932773

RECRUITING NA 300 participants

Fear and Avoidance in PTSD Patients

The University of Texas Health Science Center, Houston

NCT04770584

RECRUITING Phase 3 300 participants

An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

Transcend Therapeutics

NCT07456696

RECRUITING NA 280 participants

Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

United States Department of Defense

NCT06957067

RECRUITING Phase 2 256 participants

Facilitation of Extinction Retention and Reconsolidation Blockade in PTSD

Boston University

NCT04468360

RECRUITING NA 221 participants

Non-invasive Nerve Stimulation for PTSD and Sleep

University of Florida

NCT03170440

RECRUITING Phase 2 200 participants

Department of Defense PTSD Adaptive Platform Trial - Intervention A - Fluoxetine

Global Coalition for Adaptive Research

NCT05948553

RECRUITING Phase 2 200 participants

Department of Defense PTSD Adaptive Platform Trial - Intervention C - Daridorexant

Global Coalition for Adaptive Research

NCT05948540

RECRUITING NA 200 participants

Neuromodulation and Neurorehabilitation for mTBI

Northwestern University

NCT03819608

RECRUITING NA 200 participants

Morning Bright Light to Improve Sleep Quality in Veterans

Portland VA Medical Center

NCT03578003

RECRUITING NA 200 participants

Approach-Avoidance and Alcohol Challenge Study in PTSD

University of Texas at Austin

NCT06002633

RECRUITING NA 195 participants

Creative Arts Program to Reduce Burnout in Healthcare Professionals

University of Colorado, Denver

NCT04276922

RECRUITING NA 194 participants

OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit

VA Office of Research and Development

NCT05156112

RECRUITING NA 180 participants

Sleep and Emotion Processing in Adolescent Post-traumatic Stress Disorder

University of Wisconsin, Madison

NCT06341413

RECRUITING Phase 2 150 participants

Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD

NYU Langone Health

NCT03667846

RECRUITING 150 participants

Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat

Yale University

NCT06371404

RECRUITING Phase 2 148 participants

Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms

Virginia Commonwealth University

NCT07071350

RECRUITING NA 136 participants

Multifaceted Intervention to Restore Resilience and Overcome Risk

Icahn School of Medicine at Mount Sinai

NCT06988787

RECRUITING NA 132 participants

Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation

Florida State University

NCT06544408

RECRUITING NA 130 participants

Imaging SV2A in Mood Disorders

Yale University

NCT02734602

RECRUITING Phase 2 128 participants

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

University of California, San Diego

NCT06273527

RECRUITING NA 120 participants

Psychotherapy Effects on Reward Processing in PTSD

University of Texas at Austin

NCT06096740

RECRUITING NA 120 participants

Cognitive Control Training for Extinction in PTSD

VA Office of Research and Development

NCT06629064

RECRUITING Phase 2 120 participants

Lofexidine Combined With Buprenorphine for Reducing Symptoms of PTSD and OU Relapse in Veterans

Pharmacotherapies for Alcohol and Substance Use Disorders Alliance

NCT04360681

RECRUITING Phase 2 120 participants

Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI

NYU Langone Health

NCT04550377

RECRUITING NA 120 participants

General Psychological Distress, PTSD, and Co-Morbidities in Healthcare Workers Consequent to COVID-19

Weill Medical College of Cornell University

NCT04626050

RECRUITING NA 120 participants

Sympathetic Overactivity in Post-traumatic Stress Disorder

Emory University

NCT01627301

RECRUITING 100 participants

Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning

Yale University

NCT01730781

RECRUITING NA 98 participants

rTMS-augmented Written Exposure Therapy for PTSD

VA Office of Research and Development

NCT05149534

RECRUITING Phase 2 96 participants

Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.

Massachusetts General Hospital

NCT07079761

RECRUITING NA 96 participants

Improving Sleep in Veterans With the Polytrauma Clinical Triad

VA Office of Research and Development

NCT06477796

RECRUITING NA 90 participants

Amygdala Memory Enhancement

Washington University School of Medicine

NCT05065450

RECRUITING NA 80 participants

The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans

Children's Hospital Los Angeles

NCT06218381

RECRUITING Phase 4 80 participants

Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder

NYU Langone Health

NCT05391971

RECRUITING NA 80 participants

Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language Learners

University of Michigan

NCT06324383

RECRUITING NA 80 participants

Brain Health & Wellness Classes for Veterans With Traumatic Brain Injury

East Bay Institute for Research and Education

NCT06150196

RECRUITING NA 80 participants

Randomized Trial of Tele Vs. Clinic TF-CBT in Puerto Rico

Medical University of South Carolina

NCT06332209

RECRUITING NA 75 participants

Determining the Right Acupuncture for Good Recovery Over Neuropsychiatric Trauma

Paul Crawford

NCT05516862

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Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 22
Phase 3 8
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Post Traumatic Stress Disorder Trial Landscape

146 indexed Post Traumatic Stress Disorder studies · 71 recruiting (49%).

Phase mix: 13 late (III/IV) vs 30 early (I/II).

Top sponsor: VA Office of Research and Development (19 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Post Traumatic Stress Disorder?

PlainTrial tracks 146 US clinical trials for Post Traumatic Stress Disorder, of which 71 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Post Traumatic Stress Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.