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Post Traumatic Stress Disorder: early-phase trial registry
110 of 265 indexed Post Traumatic Stress Disorder trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #37 of 28,707 conditions by registered trial count.
265 US clinical trials · 110 currently recruiting · #37 of 28,707 conditions by registered trial count
Post Traumatic Stress Disorder: 265 US clinical trials tracked, 110 recruiting.
Post Traumatic Stress Disorder is the subject of 265 registered US clinical trials on ClinicalTrials.gov, 110 of them currently open to new participants. 22 are in Phase 3-4 (later-stage) and 46 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 45 of these trials.
Enrollment posture brief
Registry condition post-traumatic-stress-disorder
OPEN 110 | RECR 42% | LATE 22 | EARLY 46 | RANK #37 | SPON 45
Volume-matched condition peers
Nearest open-share peer: Glaucoma (41% recruiting · 94 trials)
Post Traumatic Stress Disorder lists 110 open slots (42% of 265 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Post Traumatic Stress Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Post Traumatic Stress Disorder is recruiting above its size-band peers.
110 of 265 indexed trials (41.5%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Post Traumatic Stress Disorder research.
VA Office of Research and Development accounts for 45 of 265 trials (17%). 130 distinct sponsors appear on at least one study for this condition label.
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Typical Post Traumatic Stress Disorder enrolment sits around 81 participants.
Median target enrolment is 81 among the 263 trials that report a genuine target (sentinel values excluded). 149 of those (56.7%) plan for fewer than 100 participants.
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Post Traumatic Stress Disorder research is mostly interventional.
250 interventional and 15 observational studies make up this index (94.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
265 total, page 1 of 6
Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress
Stanford University
NCT05701111
RIVER At Home Ketamine Protocols
RIVER Foundation
NCT06070766
Department of Defense PTSD Adaptive Platform Trial - Master Protocol
Global Coalition for Adaptive Research
NCT05422612
Evaluation of the Parenting in the Moment Online Program for Forcibly Displaced Families
Arizona State University
NCT06548126
Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study
Johns Hopkins University
NCT07227337
CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos
Drexel University
NCT06139159
CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
University of Texas at Austin
NCT05467683
Stepped Care for Posttraumatic Stress Disorder Study
Boston Medical Center
NCT06947538
A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD
United States Department of Defense
NCT06990191
Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers
University of Michigan
NCT05751473
Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors
Duke University
NCT06538246
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Vanderbilt University Medical Center
NCT04801589
Testing a Scalable Model of Care to Improve Patients Access to Mental Health Services After Traumatic Injury
Medical University of South Carolina
NCT05497115
Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD
The University of Texas at Dallas
NCT03932773
Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety
Baylor College of Medicine
NCT05843695
Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)
The University of Texas Health Science Center at San Antonio
NCT07176273
Fear and Avoidance in PTSD Patients
The University of Texas Health Science Center, Houston
NCT04770584
An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)
Transcend Therapeutics
NCT07456696
Testing a PTSD m-Health Intervention to Improve Alcohol Treatment Outcomes
Michigan State University
NCT05564663
Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center
Baylor Research Institute
NCT06210711
Evaluation of Trauma Center-Based Intervention for Adolescent Traumatic Injury Survivors
Medical University of South Carolina
NCT05086757
Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course
United States Department of Defense
NCT06957067
Facilitation of Extinction Retention and Reconsolidation Blockade in PTSD
Boston University
NCT04468360
Non-invasive Nerve Stimulation for PTSD and Sleep
University of Florida
NCT03170440
Investigating Cardiac Health of Adults With Trauma
Nova Southeastern University
NCT05700201
Department of Defense PTSD Adaptive Platform Trial - Intervention A - Fluoxetine
Global Coalition for Adaptive Research
NCT05948553
Department of Defense PTSD Adaptive Platform Trial - Intervention C - Daridorexant
Global Coalition for Adaptive Research
NCT05948540
Neuromodulation and Neurorehabilitation for mTBI
Northwestern University
NCT03819608
Morning Bright Light to Improve Sleep Quality in Veterans
Portland VA Medical Center
NCT03578003
Approach-Avoidance and Alcohol Challenge Study in PTSD
University of Texas at Austin
NCT06002633
Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder
VA Office of Research and Development
NCT05780177
Family Involvement in Treatment for PTSD (FIT-PTSD): A Brief, Feasible Method for Enhancing Outcomes, Retention, and Engagement
VA Office of Research and Development
NCT05267665
Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD
Texas A&M University
NCT05959434
Creative Arts Program to Reduce Burnout in Healthcare Professionals
University of Colorado, Denver
NCT04276922
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
VA Office of Research and Development
NCT05156112
Sleep and Emotion Processing in Adolescent Post-traumatic Stress Disorder
University of Wisconsin, Madison
NCT06341413
Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety
University of Texas at Austin
NCT05427708
Ketamine, SGB and Combination Treatment for TBI
Northwestern University
NCT06608277
Written Exposure Therapy for Veterans With SUD and PTSD
VA Office of Research and Development
NCT05327504
Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder
University of California, Los Angeles
NCT05516277
Enhancing Week-long Psychological Treatment for PTSD With Ketamine
Yale University
NCT05737693
Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD
NYU Langone Health
NCT03667846
Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat
Yale University
NCT06371404
Mobile Anger Reduction Intervention
VA Office of Research and Development
NCT06094933
Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms
Virginia Commonwealth University
NCT07071350
Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship
Medical University of South Carolina
NCT05786157
Multifaceted Intervention to Restore Resilience and Overcome Risk
Icahn School of Medicine at Mount Sinai
NCT06988787
Positive Processes and Transition to Health (PATH)
Case Western Reserve University
NCT06093906
Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD
University of Vermont
NCT06288711
Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation
Florida State University
NCT06544408
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 31 |
| Phase 3 | 11 |
| Phase 4 | 11 |
Top Sponsors
Named interventions
Most-linked intervention names on Post Traumatic Stress Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Post Traumatic Stress Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Post Traumatic Stress Disorder page
265 registered trials, 110 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 110 Post Traumatic Stress Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Post Traumatic Stress Disorder trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Post Traumatic Stress Disorder condition card totals 265 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.