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Aging clinical trials
Every US clinical trial registered for Aging — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
263 US clinical trials · 126 currently recruiting
The research picture
Aging has 263 registered US clinical trials, 126 of them open to new participants right now — about 48% of the total.
- 126
- recruiting participants now
- 48%
- of trials open to enrollment
- 14
- in Phase 3–4 (later-stage)
- 14
- top sponsor: University of Florida
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Apple Health Study
Apple
NCT06958523
The Lake Nona Life Project
University of Central Florida
NCT02533804
Baltimore Longitudinal Study of Aging
National Institute on Aging (NIA)
NCT00233272
Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 2
Massachusetts General Hospital
NCT07166861
Enhancing Attention and Wellbeing Using Digital Therapeutics
University of California, San Francis
NCT06397469
Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty
University of Colorado, Denver
NCT06953375
Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders
University of Michigan
NCT05929703
Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
Neurobehavioral Systems
NCT04800588
Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce
University of North Carolina, Chapel Hill
NCT06239688
DC Longitudinal Study on Aging and Specimen Bank
Georgetown University
NCT03702907
Vanderbilt Memory and Aging Project
Vanderbilt University Medical Center
NCT05372159
Tennessee Alzheimer's Project
Vanderbilt University Medical Center
NCT05372172
Arlington Aging Study
The University of Texas at Arlington
NCT06857877
Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health
Marquette University
NCT05344001
Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging
National Institute on Aging (NIA)
NCT07099053
A Study of Dual-task Exercise Training to Prevent Falls Among Older Adults With Mild Cognitive Impairment
Oregon Research Institute
NCT05725668
The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults
Mayo Clinic
NCT06940037
Exercise to Improve Brain Health in Older African Americans
Rutgers, The State University of New Jersey
NCT05597124
MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and Depression
VA Office of Research and Development
NCT05220202
Clean Hands Accessible and Manageable for Patients (CHAMPs)
Case Western Reserve University
NCT05866393
Molecular Indicators of Systematic Fitness
VO Health
NCT07393841
Heterogeneity of Vascular Adaptations to Exercise With Aging in Women and Men
University of Colorado, Denver
NCT06912984
Arterial Stiffness and Blood Pressure
VA Office of Research and Development
NCT06495710
Synbiotic to Attenuate Resorption of the Skeleton
Hebrew SeniorLife
NCT06389539
The Effect of NAD Supplementation on Brain Vascular Health in Aging
University of Oklahoma
NCT05483465
SMART Exercise for PAD
Northwestern University
NCT06032065
The Role of the Locus Coeruleus in Age-related Distractibility
Virginia Polytechnic Institute and State University
NCT05574634
Optimization of a Behavioral Intervention to Increase Physical Activity in Older Adults Living With HIV
Butler Hospital
NCT05752500
RESTOR: PK/PD mTORi Inhibition in Older Adults
The University of Texas Health Science Center at San Antonio
NCT06658093
Identification of Critical Thermal Environments for Aged Adults
Penn State University
NCT04284397
Targeting Aging With a Ketone Ester for Function in Frailty
Buck Institute for Research on Aging
NCT06645847
Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging
University of Kansas Medical Center
NCT06123182
Brain Health Virtual Reality Study
University of California, San Diego
NCT06124339
Passive Heat Therapy for Lowering Systolic Blood Pressure and Improving Vascular Function in Mid-life and Older Adults
University of Colorado, Boulder
NCT05300971
Gerofit and Cognition
VA Office of Research and Development
NCT06107842
BID WM Digital Intervention in Aging
University of California, San Francis
NCT06918704
Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation
AgelessRx
NCT07092618
Understanding Aided Speech Perception in Noise
University of South Florida
NCT06377215
Technical Development of Multi-Parametric Renocerebral MRI
University of Minnesota
NCT02831335
Improving PCP Advance Care Planning for People With ADRD
University of Pittsburgh
NCT06565169
Mechanisms of Anabolic Resistance in Older Humans
Mayo Clinic
NCT06617195
Testing Effectiveness of a Stochastic Noise Stimulator to Immediately Improve Balance and Gait
Massachusetts Eye and Ear Infirmary
NCT06688578
Mode of Exercise and Bone Biomarkers in Older Veterans
VA Office of Research and Development
NCT05266976
Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women
Marquette University
NCT03888040
Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults
Douglas Seals
NCT03821623
Influence of Brain Oscillation-Dependent TMS on Motor Function
National Institute of Neurological Disorders and Stroke (NINDS)
NCT03288220
Inspiratory Muscle Strength Training in Chronic Kidney Disease
University of Colorado, Denver
NCT04911491
Tau PET in Imaging and Cognition: Healthy Adults From 55-90
Yaakov Stern
NCT03372317
bpMedManage: Digital Technology to Support Adherence to Hypertension Medications
University of Arizona
NCT06307574
Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV
Massachusetts General Hospital
NCT06554717
Cardiometabolic Consequences of the Loss of Ovarian Function
University of Colorado, Denver
NCT06264882
Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older
Wake Forest University Health Sciences
NCT05858034
Metabolic and Functional Consequences of Aging in Health and Disease
Texas A&M University
NCT05240885
Mindfulness for Cognition in Early-stage Alzheimer's Disease
VA Boston Healthcare System
NCT06792877
Multimodal Musical Stimulation for Healthy Neurocognitive Aging
Northeastern University
NCT06229093
Heat Waves and the Elderly - Cooling Modalities
University of Texas Southwestern Medical Center
NCT05484739
Speech Perception and High Cognitive Demand
University of Maryland, College Park
NCT04997577
Studying the Effects of Digital Interventions on Cognition, Wellbeing, Stress, and Sleep in Older Adults
University of California, San Francis
NCT06633978
Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise
University of Colorado, Boulder
NCT05000515
Neurobiological Mechanisms of Aging and Stress on Prospective Navigation
Georgia Institute of Technology
NCT03896529
Empagliflozin Reversal of Arterial StiffnEss in Aging
University of Missouri-Columbia
NCT06506422
Emotional Well-being and Measures of Healthy Aging
Northwestern University
NCT07334106
Effect of Walnuts on Cognitive Function and Gut Microbiome in Older Adults
Oregon State University
NCT06942351
Molecular Optimization Via Exercise (MOVE)
Buck Institute for Research on Aging
NCT06540287
IH, Brain Health, and T2D
Darren P Casey
NCT07173543
The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population
Wright State University
NCT06428721
A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults
The Jackson Laboratory
NCT05518500
Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
University of Missouri-Columbia
NCT06417177
Cognitive Remediation
Cutter Lindbergh
NCT07171450
Postural Control During Concurrent Cognitive Tasks During Optic Flow Stimulation
Chia-Cheng Lin, PhD, PT, MSPT
NCT05117463
Effects of Obesity in the Aged
University of Texas Southwestern Medical Center
NCT05028309
Feasibility of Home-based tES for Older Adults at Risk of Falling
Hebrew SeniorLife
NCT04732533
Rapalog Pharmacology (RAP PAC) Study
University of Wisconsin, Madison
NCT05949658
Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia
Wright State University
NCT03906253
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse
Joel Trinity
NCT04351113
Using Reinforcement Learning to Personalize Electronic Health Record Tools to Facilitate Deprescribing
Brigham and Women's Hospital
NCT06660979
Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging
University of Florida
NCT05457725
Optimizing Strength Training in Older Adults
Queens College, The City University of New York
NCT06812143
Acetate and Age-associated Arterial Dysfunction
University of Colorado, Denver
NCT05424263
Early Neurovascular Adaptations in Aging Women
University of Missouri-Columbia
NCT06520982
The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses
State University of New York at Buffalo
NCT06128915
Effect of Snacks on Aging
University of California, Los Angeles
NCT06879626
MTOR Inhibitors in Older Adults
University of Texas Southwestern Medical Center
NCT06727305
Fatty Acid Modulation of Brain Function in Older Adults
University of Vermont
NCT06192407
The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults
UConn Health
NCT06027554
Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals
Medical College of Wisconsin
NCT05808686
Reducing Blood Pressure in Mid-life Adult Binge Drinkers
The University of Texas at Arlington
NCT05522075
Breaking Sitting with High-intensity Interval Training for Brain Health
University of Illinois at Urbana-Champaign
NCT06243016
The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults
AdventHealth Translational Research Institute
NCT03761446
Using Nicotine to Reverse Age-related Auditory Processing Deficits
University of California, Irvine
NCT04971954
Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex
University of California, Berkeley
NCT05018117
Transient Receptor Potential Channels
Penn State University
NCT06444594
Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities
Brigham and Women's Hospital
NCT06989619
Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults
Scott Silveira
NCT07144527
Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults
University of California, Berkeley
NCT06367738
Preliminary Testing of Cafe Move for Primary Prevention of Physical Frailty
University of Montana
NCT05720507
Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
University of Alabama at Birmingham
NCT06217575
Effect of a Daily Supplement on Plasma PAI-1 Levels
University of California, Los Angeles
NCT07469475
Fisetin to Reduce Senescence and Mobility Impairment in PAD
Northwestern University
NCT06399809
Pain and Split-belt Motor Learning in Older Adults
University of Delaware
NCT07054840
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 29 |
| Phase 2 | 19 |
| Phase 3 | 6 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Aging Trial Landscape
ClinicalTrials.gov lists 263 US studies indexed under Aging, and 126 of those are currently open to recruitment — roughly 48% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Aging shows 14 late-stage studies (Phase 3 and Phase 4 combined) alongside 48 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Aging is led by University of Florida with 14 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Aging?
PlainTrial tracks 263 US clinical trials for Aging, of which 126 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Aging?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.