Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 126 recruiting now official registry

Aging clinical trials

Every US clinical trial registered for Aging — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

263 US clinical trials · 126 currently recruiting

The research picture

Aging has 263 registered US clinical trials, 126 of them open to new participants right now — about 48% of the total.

126
recruiting participants now
48%
of trials open to enrollment
14
in Phase 3–4 (later-stage)
14
top sponsor: University of Florida

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 500,000 participants

Apple Health Study

Apple

NCT06958523

RECRUITING 10,000 participants

The Lake Nona Life Project

University of Central Florida

NCT02533804

RECRUITING 10,000 participants

Baltimore Longitudinal Study of Aging

National Institute on Aging (NIA)

NCT00233272

RECRUITING NA 6,080 participants

Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 2

Massachusetts General Hospital

NCT07166861

RECRUITING NA 4,000 participants

Enhancing Attention and Wellbeing Using Digital Therapeutics

University of California, San Francis

NCT06397469

RECRUITING NA 3,250 participants

Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty

University of Colorado, Denver

NCT06953375

RECRUITING NA 3,000 participants

Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

University of Michigan

NCT05929703

RECRUITING NA 2,000 participants

Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

Neurobehavioral Systems

NCT04800588

RECRUITING NA 1,764 participants

Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce

University of North Carolina, Chapel Hill

NCT06239688

RECRUITING 1,000 participants

DC Longitudinal Study on Aging and Specimen Bank

Georgetown University

NCT03702907

RECRUITING 1,000 participants

Vanderbilt Memory and Aging Project

Vanderbilt University Medical Center

NCT05372159

RECRUITING 1,000 participants

Tennessee Alzheimer's Project

Vanderbilt University Medical Center

NCT05372172

RECRUITING 770 participants

Arlington Aging Study

The University of Texas at Arlington

NCT06857877

RECRUITING 450 participants

Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health

Marquette University

NCT05344001

RECRUITING 400 participants

Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging

National Institute on Aging (NIA)

NCT07099053

RECRUITING NA 336 participants

A Study of Dual-task Exercise Training to Prevent Falls Among Older Adults With Mild Cognitive Impairment

Oregon Research Institute

NCT05725668

RECRUITING NA 300 participants

The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults

Mayo Clinic

NCT06940037

RECRUITING Phase 2 280 participants

Exercise to Improve Brain Health in Older African Americans

Rutgers, The State University of New Jersey

NCT05597124

RECRUITING NA 264 participants

MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and Depression

VA Office of Research and Development

NCT05220202

RECRUITING NA 250 participants

Clean Hands Accessible and Manageable for Patients (CHAMPs)

Case Western Reserve University

NCT05866393

RECRUITING 250 participants

Molecular Indicators of Systematic Fitness

VO Health

NCT07393841

RECRUITING NA 242 participants

Heterogeneity of Vascular Adaptations to Exercise With Aging in Women and Men

University of Colorado, Denver

NCT06912984

RECRUITING NA 228 participants

Arterial Stiffness and Blood Pressure

VA Office of Research and Development

NCT06495710

RECRUITING NA 220 participants

Synbiotic to Attenuate Resorption of the Skeleton

Hebrew SeniorLife

NCT06389539

RECRUITING Phase 4 214 participants

The Effect of NAD Supplementation on Brain Vascular Health in Aging

University of Oklahoma

NCT05483465

RECRUITING Phase 3 210 participants

SMART Exercise for PAD

Northwestern University

NCT06032065

RECRUITING NA 200 participants

The Role of the Locus Coeruleus in Age-related Distractibility

Virginia Polytechnic Institute and State University

NCT05574634

RECRUITING NA 196 participants

Optimization of a Behavioral Intervention to Increase Physical Activity in Older Adults Living With HIV

Butler Hospital

NCT05752500

RECRUITING Early Phase 1 194 participants

RESTOR: PK/PD mTORi Inhibition in Older Adults

The University of Texas Health Science Center at San Antonio

NCT06658093

RECRUITING Early Phase 1 190 participants

Identification of Critical Thermal Environments for Aged Adults

Penn State University

NCT04284397

RECRUITING NA 180 participants

Targeting Aging With a Ketone Ester for Function in Frailty

Buck Institute for Research on Aging

NCT06645847

RECRUITING NA 160 participants

Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging

University of Kansas Medical Center

NCT06123182

RECRUITING NA 150 participants

Brain Health Virtual Reality Study

University of California, San Diego

NCT06124339

RECRUITING NA 150 participants

Passive Heat Therapy for Lowering Systolic Blood Pressure and Improving Vascular Function in Mid-life and Older Adults

University of Colorado, Boulder

NCT05300971

RECRUITING NA 150 participants

Gerofit and Cognition

VA Office of Research and Development

NCT06107842

RECRUITING NA 150 participants

BID WM Digital Intervention in Aging

University of California, San Francis

NCT06918704

RECRUITING Phase 2 150 participants

Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation

AgelessRx

NCT07092618

RECRUITING NA 121 participants

Understanding Aided Speech Perception in Noise

University of South Florida

NCT06377215

RECRUITING 120 participants

Technical Development of Multi-Parametric Renocerebral MRI

University of Minnesota

NCT02831335

RECRUITING NA 120 participants

Improving PCP Advance Care Planning for People With ADRD

University of Pittsburgh

NCT06565169

RECRUITING 120 participants

Mechanisms of Anabolic Resistance in Older Humans

Mayo Clinic

NCT06617195

RECRUITING NA 120 participants

Testing Effectiveness of a Stochastic Noise Stimulator to Immediately Improve Balance and Gait

Massachusetts Eye and Ear Infirmary

NCT06688578

RECRUITING NA 120 participants

Mode of Exercise and Bone Biomarkers in Older Veterans

VA Office of Research and Development

NCT05266976

RECRUITING NA 120 participants

Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women

Marquette University

NCT03888040

RECRUITING Phase 2 118 participants

Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

Douglas Seals

NCT03821623

RECRUITING 114 participants

Influence of Brain Oscillation-Dependent TMS on Motor Function

National Institute of Neurological Disorders and Stroke (NINDS)

NCT03288220

RECRUITING NA 108 participants

Inspiratory Muscle Strength Training in Chronic Kidney Disease

University of Colorado, Denver

NCT04911491

RECRUITING 105 participants

Tau PET in Imaging and Cognition: Healthy Adults From 55-90

Yaakov Stern

NCT03372317

RECRUITING NA 100 participants

bpMedManage: Digital Technology to Support Adherence to Hypertension Medications

University of Arizona

NCT06307574

RECRUITING Phase 2 100 participants

Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV

Massachusetts General Hospital

NCT06554717

RECRUITING Phase 4 100 participants

Cardiometabolic Consequences of the Loss of Ovarian Function

University of Colorado, Denver

NCT06264882

RECRUITING NA 100 participants

Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older

Wake Forest University Health Sciences

NCT05858034

RECRUITING 100 participants

Metabolic and Functional Consequences of Aging in Health and Disease

Texas A&M University

NCT05240885

RECRUITING NA 100 participants

Mindfulness for Cognition in Early-stage Alzheimer's Disease

VA Boston Healthcare System

NCT06792877

RECRUITING NA 100 participants

Multimodal Musical Stimulation for Healthy Neurocognitive Aging

Northeastern University

NCT06229093

RECRUITING NA 100 participants

Heat Waves and the Elderly - Cooling Modalities

University of Texas Southwestern Medical Center

NCT05484739

RECRUITING NA 100 participants

Speech Perception and High Cognitive Demand

University of Maryland, College Park

NCT04997577

RECRUITING NA 90 participants

Studying the Effects of Digital Interventions on Cognition, Wellbeing, Stress, and Sleep in Older Adults

University of California, San Francis

NCT06633978

RECRUITING NA 90 participants

Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise

University of Colorado, Boulder

NCT05000515

RECRUITING NA 85 participants

Neurobiological Mechanisms of Aging and Stress on Prospective Navigation

Georgia Institute of Technology

NCT03896529

RECRUITING Phase 2 80 participants

Empagliflozin Reversal of Arterial StiffnEss in Aging

University of Missouri-Columbia

NCT06506422

RECRUITING NA 80 participants

Emotional Well-being and Measures of Healthy Aging

Northwestern University

NCT07334106

RECRUITING NA 80 participants

Effect of Walnuts on Cognitive Function and Gut Microbiome in Older Adults

Oregon State University

NCT06942351

RECRUITING 80 participants

Molecular Optimization Via Exercise (MOVE)

Buck Institute for Research on Aging

NCT06540287

RECRUITING NA 80 participants

IH, Brain Health, and T2D

Darren P Casey

NCT07173543

RECRUITING NA 80 participants

The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

Wright State University

NCT06428721

RECRUITING Phase 4 75 participants

A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults

The Jackson Laboratory

NCT05518500

RECRUITING Early Phase 1 75 participants

Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

University of Missouri-Columbia

NCT06417177

RECRUITING NA 75 participants

Cognitive Remediation

Cutter Lindbergh

NCT07171450

RECRUITING 72 participants

Postural Control During Concurrent Cognitive Tasks During Optic Flow Stimulation

Chia-Cheng Lin, PhD, PT, MSPT

NCT05117463

RECRUITING NA 72 participants

Effects of Obesity in the Aged

University of Texas Southwestern Medical Center

NCT05028309

RECRUITING NA 72 participants

Feasibility of Home-based tES for Older Adults at Risk of Falling

Hebrew SeniorLife

NCT04732533

RECRUITING Phase 1 72 participants

Rapalog Pharmacology (RAP PAC) Study

University of Wisconsin, Madison

NCT05949658

RECRUITING NA 72 participants

Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia

Wright State University

NCT03906253

RECRUITING NA 72 participants

Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse

Joel Trinity

NCT04351113

RECRUITING NA 70 participants

Using Reinforcement Learning to Personalize Electronic Health Record Tools to Facilitate Deprescribing

Brigham and Women's Hospital

NCT06660979

RECRUITING NA 68 participants

Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging

University of Florida

NCT05457725

RECRUITING NA 68 participants

Optimizing Strength Training in Older Adults

Queens College, The City University of New York

NCT06812143

RECRUITING Phase 2 66 participants

Acetate and Age-associated Arterial Dysfunction

University of Colorado, Denver

NCT05424263

RECRUITING Early Phase 1 64 participants

Early Neurovascular Adaptations in Aging Women

University of Missouri-Columbia

NCT06520982

RECRUITING Phase 4 60 participants

The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses

State University of New York at Buffalo

NCT06128915

RECRUITING NA 60 participants

Effect of Snacks on Aging

University of California, Los Angeles

NCT06879626

RECRUITING Phase 1 60 participants

MTOR Inhibitors in Older Adults

University of Texas Southwestern Medical Center

NCT06727305

RECRUITING NA 60 participants

Fatty Acid Modulation of Brain Function in Older Adults

University of Vermont

NCT06192407

RECRUITING Phase 2 60 participants

The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults

UConn Health

NCT06027554

RECRUITING Phase 2 60 participants

Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals

Medical College of Wisconsin

NCT05808686

RECRUITING NA 55 participants

Reducing Blood Pressure in Mid-life Adult Binge Drinkers

The University of Texas at Arlington

NCT05522075

RECRUITING NA 54 participants

Breaking Sitting with High-intensity Interval Training for Brain Health

University of Illinois at Urbana-Champaign

NCT06243016

RECRUITING NA 50 participants

The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults

AdventHealth Translational Research Institute

NCT03761446

RECRUITING NA 48 participants

Using Nicotine to Reverse Age-related Auditory Processing Deficits

University of California, Irvine

NCT04971954

RECRUITING Early Phase 1 48 participants

Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex

University of California, Berkeley

NCT05018117

RECRUITING Early Phase 1 45 participants

Transient Receptor Potential Channels

Penn State University

NCT06444594

RECRUITING NA 45 participants

Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities

Brigham and Women's Hospital

NCT06989619

RECRUITING NA 40 participants

Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults

Scott Silveira

NCT07144527

RECRUITING Phase 1 40 participants

Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults

University of California, Berkeley

NCT06367738

RECRUITING NA 36 participants

Preliminary Testing of Cafe Move for Primary Prevention of Physical Frailty

University of Montana

NCT05720507

RECRUITING NA 36 participants

Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans

University of Alabama at Birmingham

NCT06217575

RECRUITING Phase 1 35 participants

Effect of a Daily Supplement on Plasma PAI-1 Levels

University of California, Los Angeles

NCT07469475

RECRUITING Phase 2 34 participants

Fisetin to Reduce Senescence and Mobility Impairment in PAD

Northwestern University

NCT06399809

RECRUITING NA 34 participants

Pain and Split-belt Motor Learning in Older Adults

University of Delaware

NCT07054840

Phase Distribution

PhaseTrial count
Phase 1 29
Phase 2 19
Phase 3 6
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Aging Trial Landscape

ClinicalTrials.gov lists 263 US studies indexed under Aging, and 126 of those are currently open to recruitment — roughly 48% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Aging shows 14 late-stage studies (Phase 3 and Phase 4 combined) alongside 48 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Aging is led by University of Florida with 14 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Aging?

PlainTrial tracks 263 US clinical trials for Aging, of which 126 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Aging?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →