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NCT05646732 · ClinicalTrials.gov registry record · NA

Targeting the Default Mode Network: A TMS-fMRI Study

A NA study of Post Traumatic Stress Disorder and PTSD, sponsored by Allyson Rosen.

Recruiting
Registry status
NA
Development phase
30
Enrollment target
1
Study location

NCT05646732: Recruiting NA study of Post Traumatic Stress Disorder and PTSD, sponsored by Allyson Rosen.

NCT05646732 is a NA study of Post Traumatic Stress Disorder and PTSD that is actively recruiting participants, run by Allyson Rosen. The registered enrollment target is 30 participants, below the 664-participant average among 262 other Post Traumatic Stress Disorder trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05646732, a NA study of Post Traumatic Stress Disorder and PTSD, is actively recruiting participants, sponsored by Allyson Rosen.

RECRUITING
Registry status
NA
Development phase
30 participants
Enrollment target
1
Study location

Study Summary

In post-traumatic stress disorder (PTSD), intrusive, traumatic, autobiographical memories lead to anxiety symptoms. Recent work suggests a new repetitive pulse transcranial magnetic stimulation (rTMS) brain target that might bring relief. Since this proposed target is not well understood, the goal of the study is to use functional magnetic resonance imaging (fMRI) to identify the brain regions and networks that change with rTMS stimulation at this target area in PTSD patients. Ultimately, this would lead to a personalized approach to rTMS treatment of PTSD based on brain imaging that can be used in a future clinical trial. Participants will be asked to complete psychological testing and questionnaires as well as an initial MRI and two separate TMS-fMRI sessions. Total participation time across all visits is estimated to be five to six hours. Research participation will take place at VA Palo Alto as well as at Stanford University.

Primary Outcome

Measure of the connectivity between the left 8Av and DMN nodes.

Conditions Studied

Post Traumatic Stress Disorder PTSD

Interventions

  • DEVICE TMS-fMRI

Study Locations (1)

California

  • VA Palo Alto - Palo Alto

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2023-08-02
Est. Completion 2025-01-31
Phase NA
Allyson Rosen

1 total trials

What NCT05646732 shows while recruiting

NCT05646732 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 664-participant average among 262 other Post Traumatic Stress Disorder trials with a reported enrollment target (95% lower).

The record links to 2 conditions, with Post Traumatic Stress Disorder appearing as the primary indexed condition, and to 1 intervention - of which TMS-fMRI is the first listed.

NCT05646732 reports a single indexed study location in California.

Frequently Asked Questions

What is clinical trial NCT05646732 about?

NCT05646732 is a clinical study titled "Targeting the Default Mode Network: A TMS-fMRI Study". In post-traumatic stress disorder (PTSD), intrusive, traumatic, autobiographical memories lead to anxiety symptoms. Recent work suggests a new repetitive pulse transcranial magnetic stimulation (rTMS) brain target that might bring relief. Since this proposed target is not well understood, the goal o...

What is the current status of trial NCT05646732?

This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2023-08-02. Estimated completion is 2025-01-31.

What conditions does trial NCT05646732 study?

This clinical trial studies the following conditions: Post Traumatic Stress Disorder, PTSD.

What interventions are being tested in trial NCT05646732?

The interventions under investigation include: TMS-fMRI (DEVICE).

Who is sponsoring clinical trial NCT05646732?

This trial is sponsored by Allyson Rosen, which has 1 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05646732 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Post Traumatic Stress Disorder

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05646732's enrollment target sits among peer trials

30 210th of 262 higher than 44 of 262 other Post Traumatic Stress Disorder trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Post Traumatic Stress Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05646732

Source: ClinicalTrials.gov NCT05646732, the US trial registry maintained by the National Library of Medicine. NCT05646732 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.