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NCT06234969 · ClinicalTrials.gov registry record · NA
A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation
A NA study of Post Traumatic Stress Disorder, sponsored by University of Pennsylvania.
- Recruiting
- Registry status
- NA
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT06234969: Recruiting NA study of Post Traumatic Stress Disorder, sponsored by University of Pennsylvania.
NCT06234969 is a NA study of Post Traumatic Stress Disorder that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 120 participants, below the 663-participant average among 262 other Post Traumatic Stress Disorder trials with a reported enrollment target (82% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06234969, a NA study of Post Traumatic Stress Disorder, is actively recruiting participants, sponsored by University of Pennsylvania.
- RECRUITING
- Registry status
- NA
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD). The investigators will demonstrate that IPS cTBS results in significant reduction in arousal (measured by startle response) compared to sham cTBS, that IPS cTBS interacts with extinction training to further improve arousal, and that there is a dose/response effect of cTBS on arousal. The investigators will also demonstrate that IPS cTBS significantly improves retention of extinction learning, the experimental analogue of exposure therapy.
Primary Outcome
Startle will be recorded from the left orbicularis oculi at 2000 Hz.
Conditions Studied
Interventions
- DEVICE Continuous Theta Burst Stimulation to the Intraparietal Sulcus
- DEVICE Sham Continuous Theta Burst Stimulation
Study Locations (1)
Pennsylvania
- Center for the Treatment and Study of Anxiety, University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2024-04-29 |
| Est. Completion | 2028-10-31 |
| Phase | NA |
What NCT06234969 shows while recruiting
NCT06234969 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 663-participant average among 262 other Post Traumatic Stress Disorder trials with a reported enrollment target (82% lower).
The record links to 1 condition, with Post Traumatic Stress Disorder appearing as the primary indexed condition, and to 2 interventions - of which Continuous Theta Burst Stimulation to the Intraparietal Sulcus is the first listed.
NCT06234969 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06234969 about?
NCT06234969 is a clinical study titled "A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation". This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD). The investigators will demonstrate that IPS cTBS results in significant reductio...
What is the current status of trial NCT06234969?
This trial is currently recruiting. It is a NA study. The enrollment target is 120 participants. The study started on 2024-04-29. Estimated completion is 2028-10-31.
What conditions does trial NCT06234969 study?
This clinical trial studies the following conditions: Post Traumatic Stress Disorder.
What interventions are being tested in trial NCT06234969?
The interventions under investigation include: Continuous Theta Burst Stimulation to the Intraparietal Sulcus (DEVICE), Sham Continuous Theta Burst Stimulation (DEVICE).
Who is sponsoring clinical trial NCT06234969?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06234969 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Post Traumatic Stress Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06234969's enrollment target sits among peer trials
120 96th of 262 higher than 158 of 262 other Post Traumatic Stress Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Post Traumatic Stress Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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