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ClinicalTrials.gov 71 recruiting now official registry

Post Traumatic Stress Disorder clinical trials

71 of 146 indexed Post Traumatic Stress Disorder trials are currently recruiting.

146 US clinical trials · 71 currently recruiting

Post Traumatic Stress Disorder is the subject of 146 registered US clinical trials on ClinicalTrials.gov, 71 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 30 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 19 of these trials.

The research picture

Post Traumatic Stress Disorder has 146 registered US clinical trials, 71 of them open to new participants right now, about 49% of the total.

71
recruiting participants now
49%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
19
top sponsor: VA Office of Research and Development
Phase 18Phase 222Phase 38Phase 45

Active & Recent Trials

146 total, page 3 of 3

COMPLETED NA 148 participants

Effects of Early Abuse on Adult Intimate Relationships

University of Texas at Austin

NCT01803802

COMPLETED Phase 2 142 participants

Treatment of Smoking Among Individuals With PTSD

University of Pennsylvania

NCT00937235

COMPLETED Phase 1 136 participants

Virtual Reality (VR) Therapy for Post-Traumatic Stress Disorder (PTSD)

Office of Naval Research (ONR)

NCT00992953

COMPLETED Phase 4 135 participants

Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy

Indiana University

NCT02213900

COMPLETED NA 134 participants

Cognitive Behavioral Treatments for Post-traumatic Stress Disorder (PTSD) Sleep Disturbance

US Department of Veterans Affairs

NCT00108628

COMPLETED NA 120 participants

Adolescent Trauma Recovery and Stress Disorders Collaborative Care (ATRSCC) Model Program Trial

University of Washington

NCT00619255

COMPLETED NA 119 participants

PTSD Affect Labeling Study

University of California, Los Angeles

NCT05924399

COMPLETED Phase 1 95 participants

Cannabidiol as a Treatment for AUD Comorbid With PTSD

NYU Langone Health

NCT03248167

COMPLETED NA 90 participants

Psychological Symptoms and Families of COVID-19 Patients

Rush University Medical Center

NCT04501445

COMPLETED Phase 3 90 participants

Comparison of Videoconference and Face-to-Face Delivery of Cognitive Processing Therapy for Posttraumatic Stress Disorder

University of Wisconsin, Madison

NCT00941629

COMPLETED NA 87 participants

Mobile Self-Tracking of Mental Health

VA Office of Research and Development

NCT05023252

COMPLETED NA 87 participants

Treatment of Older Veterans With Chronic Posttraumatic Stress Disorder

US Department of Veterans Affairs

NCT00539279

COMPLETED NA 86 participants

Effectiveness of Cognitive, Exposure, and Skills Group Manualized Treatments in Operations Iraqi (OIF)/Operation Enduring Freedom (OEF) Female Veterans

New Mexico VA Healthcare System

NCT02069873

COMPLETED 81 participants

Telerehabilitation for OIF/OEF Returnees With Combat-Related Traumatic Brain Injury

VA Office of Research and Development

NCT00676182

COMPLETED NA 80 participants

Primary-Care Based Mindfulness Intervention

Emory University

NCT03922581

COMPLETED NA 76 participants

Rehabilitation of Executive Functioning in Veterans With PTSD and Mild TBI

VA Office of Research and Development

NCT01921179

COMPLETED Phase 1 75 participants

Biological Signatures, Probiotic Among Those With mTBI and PTSD

VA Office of Research and Development

NCT02723344

COMPLETED NA 74 participants

Brief Cognitive Behavioral Treatment of Deployment-Related PTSD Symptoms in Primary Care Settings

The University of Texas Health Science Center at San Antonio

NCT02290639

COMPLETED NA 65 participants

Physiological Augmentation of Mindfulness Meditation

Emory University

NCT02754557

COMPLETED NA 59 participants

Increasing Engagement in Evidence-Based PTSD Therapy for Primary Care Veterans

VA Office of Research and Development

NCT01984515

COMPLETED Phase 1 57 participants

Bringing What Works to Youth in Corrections: A Trauma Intervention

University of Texas at Austin

NCT01560728

COMPLETED NA 55 participants

Primary Care Brief Mindfulness Training for Veterans With PTSD

Syracuse VA Medical Center

NCT03352011

COMPLETED NA 45 participants

Effect of Mindfulness Meditation on Physiological Response to Unpredictable Stimuli

Georgetown University

NCT03206437

COMPLETED NA 45 participants

The Effects of the Safe and Sound Protocol on PTSD Symptoms and Anxiety

Indiana University

NCT04999852

COMPLETED Phase 4 43 participants

Effect of Propranolol on Preventing Posttraumatic Stress Disorder

Massachusetts General Hospital

NCT00158262

COMPLETED NA 41 participants

Effects of a Short-term Exercise Intervention on Sleep in Women Exposed to Trauma: A Randomized Controlled Trial

University of Georgia

NCT05097352

COMPLETED 40 participants

Role of Substance P in Post-Traumatic Stress Disorder

National Institute of Mental Health (NIMH)

NCT00102102

COMPLETED NA 34 participants

Mindful Self Compassion for Combat Deployed Veterans With Moral Injury and Co-occurring PTSD-SUD

VA Office of Research and Development

NCT03681288

COMPLETED NA 32 participants

Yoga and Mantram for Chronic Pain and PTSD

VA Office of Research and Development

NCT03816007

COMPLETED 30 participants

Perceptions of MDMA-Assisted Therapy Among Veterans With PTSD

Albany Research Institute

NCT05895318

COMPLETED Phase 3 30 participants

Frontline Clinician Psilocybin Study

University of Washington

NCT05163496

COMPLETED NA 30 participants

Written Exposure Therapy to Improve Recovery Among Sexual Assault Survivors

University of North Carolina, Chapel Hill

NCT06571513

COMPLETED Early Phase 1 28 participants

Quetiapine Augmentation of PE Therapy for the Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury

The University of Texas Health Science Center at San Antonio

NCT04280965

COMPLETED Phase 3 28 participants

Maximizing Treatment Outcome in Post-Traumatic Stress Disorder (PTSD)

University of Texas at Austin

NCT01998100

COMPLETED Phase 2 26 participants

Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) With/Without Yohimbine

VA Office of Research and Development

NCT01031979

COMPLETED NA 25 participants

Transcranial Direct Current Stimulation (tDCS) in Human Subjects With PTSD Receiving an Exposure-based, Behavioral Therapy

The University of Texas Health Science Center at San Antonio

NCT05419999

COMPLETED NA 24 participants

Effect of Repetitive Transcranial Direct Current Stimulation (tDCS) on Chronic Pelvic Pain

Summa Health System

NCT00554320

COMPLETED Phase 2 24 participants

Body-Oriented Therapy for Sexual Abuse Recovery

National Center for Complementary and Integrative Health (NCCIH)

NCT00097305

COMPLETED 18 participants

The Effect of Nasal Continuous Positive Airway Pressure Treatment on PTSD Symptoms.

Northport Veterans Affairs Medical Center

NCT01512771

COMPLETED NA 16 participants

Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma

University of Massachusetts, Worcester

NCT03845985

COMPLETED NA 16 participants

Trauma Intervention for Affect Regulation, AIDS, and Substances

University of Miami

NCT02923141

COMPLETED Phase 4 12 participants

Short Course Glucocorticoid Treatment for PTSD

University of Wisconsin, Madison

NCT00204737

COMPLETED NA 9 participants

CCTAP: Cognitive Control Training for Treatment of AUD-PTSD

Posit Science Corporation

NCT03200028

COMPLETED Phase 3 9 participants

Maximizing Treatment Outcome and Examining Sleep in Post-traumatic Stress Disorder (PTSD)

Southern Methodist University

NCT01199107

COMPLETED NA 7 participants

Pilot Study of PRX-03140 to Assess Safety for Use in Adult Subjects With Post Traumatic Stress Disorder

Alachua Government Services

NCT01492699

COMPLETED NA

Hyporeactivity and Gulf War Illness

US Department of Veterans Affairs

NCT00100412

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Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 22
Phase 3 8
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Post Traumatic Stress Disorder Trial Landscape

146 indexed Post Traumatic Stress Disorder studies · 71 recruiting (49%).

Phase mix: 13 late (III/IV) vs 30 early (I/II).

Top sponsor: VA Office of Research and Development (19 trials), 9 others listed. 46 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Post Traumatic Stress Disorder?

PlainTrial tracks 146 US clinical trials for Post Traumatic Stress Disorder, of which 71 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Post Traumatic Stress Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.