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Nicotine Dependence: early-phase trial registry
19 of 69 indexed Nicotine Dependence trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #201 of 28,707 conditions by registered trial count.
69 US clinical trials · 19 currently recruiting · #201 of 28,707 conditions by registered trial count
Nicotine Dependence: 69 US clinical trials tracked, 19 recruiting.
Nicotine Dependence is the subject of 69 registered US clinical trials on ClinicalTrials.gov, 19 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 9 of these trials.
Enrollment posture brief
Registry condition nicotine-dependence
OPEN 19 | RECR 28% | LATE 13 | EARLY 22 | RANK #201 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Hypoxia (28% recruiting · 40 trials)
Nicotine Dependence lists 19 open slots (28% of 69 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Nicotine Dependence on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Nicotine Dependence is recruiting below its size-band peers.
19 of 69 indexed trials (27.5%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Nicotine Dependence trials is spread across many organizations.
Yale University accounts for 9 of 69 trials (13%). 34 distinct sponsors appear on at least one study for this condition label.
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Typical Nicotine Dependence enrolment sits around 104 participants.
Median target enrolment is 104 among the 68 trials that report a genuine target (sentinel values excluded). 33 of those (48.5%) plan for fewer than 100 participants.
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Nicotine Dependence research is mostly interventional.
64 interventional and 5 observational studies make up this index (92.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
69 total, page 1 of 2
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
National Institute on Drug Abuse (NIDA)
NCT01036581
Overcoming Nicotine Dependence to Enable Quitting
Rush University Medical Center
NCT05513872
Behavioral Intervention for Youth to Promote Vaping Cessation
Massachusetts General Hospital
NCT06765291
Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity.
Jasper A. Smits
NCT06053567
Young Adult Tobacco/Nicotine and Cannabis Co-use
Medical University of South Carolina
NCT06239350
Optimizing Tobacco Use Treatment for PLWHA
University of Pennsylvania
NCT04176172
A Trial of Varenicline for E-cigarette Cessation
Yale University
NCT07040566
Abuse Liability and Appeal of Oral Nicotine Products
University of Southern California
NCT06506162
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
Yale University
NCT06077240
Orexin s Role in the Neurobiology of Substance Use Disorder
National Institute on Drug Abuse (NIDA)
NCT05630781
E-cigarette Cessation in Adults Who Co-use Cannabis
Medical University of South Carolina
NCT06688539
Effects of Cannabidiol on Stress and Nicotine Withdrawal
Johns Hopkins University
NCT07001930
Beta-Adrenergic Modulation of Drug Cue Reactivity
University of Oklahoma
NCT05587361
IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate
Yale University
NCT05176418
Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
Medical University of South Carolina
NCT06678789
NeuroControl of Nicotine Dependence
University of Missouri-Columbia
NCT06347055
Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Masonic Cancer Center, University of Minnesota
NCT06295757
Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)
University of California, San Francisco
NCT05658471
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
University of California, San Francisco
NCT05962229
Methadone-Maintained Smokers Switching to E-Cigarettes
Butler Hospital
NCT05206435
Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal
University of Alabama at Birmingham
NCT03968900
A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers
University of Wisconsin, Madison
NCT01553084
Testing an Organizational Change Model to Address Smoking in Mental Healthcare
University of Pennsylvania
NCT02849652
Improving Tobacco Treatment Rates for Cancer Patients Who Smoke
Abramson Cancer Center at Penn Medicine
NCT04738643
Cessation Screening Project
University of Wisconsin, Madison
NCT04188873
Identifying Treatments to Motivate Smokers to Quit
University of Wisconsin, Madison
NCT01122238
A Follow-up Study to Assess Long-term Immunogenicity and Safety of NicVAX/Placebo as an Aid to Smoking Cessation
Nabi Biopharmaceuticals
NCT01304810
Smoking Treatment in HIV Clinical Care Settings
University of California, San Francisco
NCT00297453
Reducing Tobacco Use Disparities Among Low-Income Adults
Northwestern University
NCT03077737
Adaptive Pharmacotherapy for Smoking Cessation
Duke University
NCT02501265
Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers
Duke University
NCT02989038
Targeted Interventions for Weight-Concerned Smokers
Yale University
NCT00105482
Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties
University of Oklahoma
NCT05095779
The Gender-Sex Hormone Interface With Craving & Stress-Related Changes in Smoking
Kevin Gray, MD
NCT01576874
Treatment of Smoking Among Individuals With PTSD
University of Pennsylvania
NCT00937235
Extended Cessation Treatment for Teen Smokers
Stanford University
NCT00459953
Menstrual Cycle Effects on Smoking Cessation and Cue Reactivity
Medical University of South Carolina
NCT00664755
Effects of Nicotine on Brain Activity as Measured by fMRI
National Institute on Drug Abuse (NIDA)
NCT01037153
Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging
Johns Hopkins University
NCT01664741
N-acetylcysteine for Tobacco Use Disorder
Medical University of South Carolina
NCT02737358
Nicotine Withdrawal Symptoms and Smoking Relapse
National Institute on Drug Abuse (NIDA)
NCT01511614
Bupropion for ADHD in Adolescents With Substance Use Disorder
University of Colorado, Denver
NCT00936299
Brain Reaction to Treatment of Nicotine Dependence
US Department of Veterans Affairs
NCT00108173
Effects of Nicotine on Elements of Attentions in Smokers and Nonsmokers
National Institute on Drug Abuse (NIDA)
NCT01034020
Evaluation of Learning-Theory-Based Smoking Cessation Strategies
Rutgers University
NCT01368653
Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms
National Institute on Drug Abuse (NIDA)
NCT01505725
Prize Reinforcement for Smoking Cessation
Wayne State University
NCT00865254
Examining a Text Message Intervention for Smoking Cessation
The Miriam Hospital
NCT01166464
Progesterone and Brain Imaging Study
University of Pennsylvania
NCT01954966
E-cigarette Nicotine Study
University of Vermont
NCT04709471
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 10 |
| Phase 2 | 12 |
| Phase 3 | 4 |
| Phase 4 | 9 |
Top Sponsors
Named interventions
Most-linked intervention names on Nicotine Dependence records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Nicotine Dependence trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Nicotine Dependence page
69 registered trials, 19 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 19 Nicotine Dependence trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Yale University sponsors the most Nicotine Dependence trials on record, review their full trial history before evaluating a specific study. See Yale University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Nicotine Dependence condition card totals 69 registered trials; most-linked intervention Nicotine Patch; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.