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NCT05962229 · ClinicalTrials.gov registry record · Phase 1
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
A Phase 1 study of Nicotine Dependence and Nicotine Vaping, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 18
- Enrollment target
- 1
- Study location
NCT05962229: Recruiting Phase 1 study of Nicotine Dependence and Nicotine Vaping, sponsored by University of California, San Francisco.
NCT05962229 is a Phase 1 study of Nicotine Dependence and Nicotine Vaping that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 18 participants, below the 186-participant average among 67 other Nicotine Dependence trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05962229, a Phase 1 study of Nicotine Dependence and Nicotine Vaping, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 18 participants
- Enrollment target
- 1
- Study location
Study Summary
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.
Primary Outcome
Plasma nicotine area under the concentrated time curve (AUC) (ng/ml\*h)
Conditions Studied
Interventions
- DRUG (S)-Nicotine
- DRUG (R)- nicotine
- DRUG Racemic nicotine
Study Locations (1)
California
- Zuckerberg San Francisco General Hospital (ZSFG) - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2024-12-06 |
| Est. Completion | 2026-09 |
| Phase | Phase 1 |
What NCT05962229 shows while recruiting
NCT05962229 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 186-participant average among 67 other Nicotine Dependence trials with a reported enrollment target (90% lower).
The record links to 2 conditions, with Nicotine Dependence appearing as the primary indexed condition, and to 3 interventions - of which (S)-Nicotine is the first listed.
NCT05962229 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05962229 about?
NCT05962229 is a clinical study titled "Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine". In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administrati...
What is the current status of trial NCT05962229?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2024-12-06. Estimated completion is 2026-09.
What conditions does trial NCT05962229 study?
This clinical trial studies the following conditions: Nicotine Dependence, Nicotine Vaping.
What interventions are being tested in trial NCT05962229?
The interventions under investigation include: (S)-Nicotine (DRUG), (R)- nicotine (DRUG), Racemic nicotine (DRUG).
Who is sponsoring clinical trial NCT05962229?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05962229 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Nicotine Dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05962229's enrollment target sits among peer trials
18 59th of 67 higher than 9 of 67 other Nicotine Dependence trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Nicotine Dependence trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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