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NCT05962229 · ClinicalTrials.gov registry record · Phase 1

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

A Phase 1 study of Nicotine Dependence and Nicotine Vaping, sponsored by University of California, San Francisco.

Recruiting
Registry status
Phase 1
Development phase
18
Enrollment target
1
Study location

NCT05962229 is a Phase 1 study of Nicotine Dependence and Nicotine Vaping that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 18 participants, below the 186-participant average among 67 other Nicotine Dependence trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05962229, a Phase 1 study of Nicotine Dependence and Nicotine Vaping, is actively recruiting participants, sponsored by University of California, San Francisco.

RECRUITING
Registry status
Phase 1
Development phase
18 participants
Enrollment target
1
Study location

Study Summary

In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.

Conditions Studied

Nicotine Dependence Nicotine Vaping

Interventions

  • DRUG (S)-Nicotine
  • DRUG (R)- nicotine
  • DRUG Racemic nicotine

Study Locations (1)

California

  • Zuckerberg San Francisco General Hospital (ZSFG) - San Francisco

Trial Details

FieldValue
Enrollment Target 18 participants
Start Date 2024-12-06
Est. Completion 2026-09
Phase Phase 1

Sponsor

University of California, San Francisco

1,713 total trials

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What the Registry Record Tells You About NCT05962229

The ClinicalTrials.gov registry entry for NCT05962229 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 18 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 186-participant average among 67 other Nicotine Dependence trials with a reported enrollment target (90% lower). The listed sponsor is University of California, San Francisco, which has 1,713 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Nicotine Dependence appearing as the primary indexed condition, and to 3 interventions - of which (S)-Nicotine is the first listed.

NCT05962229 reports 1 study location spanning 1 distinct geographic area - top geographies include California.

Frequently Asked Questions

What is clinical trial NCT05962229 about?

NCT05962229 is a clinical study titled "Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine". In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administrati...

What is the current status of trial NCT05962229?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2024-12-06. Estimated completion is 2026-09.

What conditions does trial NCT05962229 study?

This clinical trial studies the following conditions: Nicotine Dependence, Nicotine Vaping.

What interventions are being tested in trial NCT05962229?

The interventions under investigation include: (S)-Nicotine (DRUG), (R)- nicotine (DRUG), Racemic nicotine (DRUG).

Who is sponsoring clinical trial NCT05962229?

This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05962229 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.