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NCT05176418 · ClinicalTrials.gov registry record · Early Phase 1

IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate

A Early Phase 1 study of Nicotine Dependence, sponsored by Yale University.

Recruiting
Registry status
Early Phase 1
Development phase
70
Enrollment target
1
Study location

NCT05176418 is a Early Phase 1 study of Nicotine Dependence that is actively recruiting participants, run by Yale University. The registered enrollment target is 70 participants, below the 186-participant average among 67 other Nicotine Dependence trials with a reported enrollment target (62% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05176418, a Early Phase 1 study of Nicotine Dependence, is actively recruiting participants, sponsored by Yale University.

RECRUITING
Registry status
Early Phase 1
Development phase
70 participants
Enrollment target
1
Study location

Study Summary

This project will examine the impact of the nicotine dose and delivery rate on nicotine's abuse potential, versus its potentially beneficial effects on smoking urges and withdrawal. Will use pulsed IV nicotine administration which closely matches nicotine delivery by inhaled tobacco use.

Conditions Studied

Nicotine Dependence

Interventions

  • DRUG low dose Nicotine
  • DRUG high dose Nicotine

Study Locations (1)

Connecticut

  • VA Healthcare System - West Haven

Trial Details

FieldValue
Enrollment Target 70 participants
Start Date 2022-09-09
Est. Completion 2026-02-01
Phase Early Phase 1

Sponsor

Yale University

1,492 total trials

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What the Registry Record Tells You About NCT05176418

The ClinicalTrials.gov registry entry for NCT05176418 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 186-participant average among 67 other Nicotine Dependence trials with a reported enrollment target (62% lower). The listed sponsor is Yale University, which has 1,492 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Nicotine Dependence appearing as the primary indexed condition, and to 2 interventions - of which low dose Nicotine is the first listed.

NCT05176418 reports 1 study location spanning 1 distinct geographic area - top geographies include Connecticut.

Frequently Asked Questions

What is clinical trial NCT05176418 about?

NCT05176418 is a clinical study titled "IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate". This project will examine the impact of the nicotine dose and delivery rate on nicotine's abuse potential, versus its potentially beneficial effects on smoking urges and withdrawal. Will use pulsed IV nicotine administration which closely matches nicotine delivery by inhaled tobacco use.

What is the current status of trial NCT05176418?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 70 participants. The study started on 2022-09-09. Estimated completion is 2026-02-01.

What conditions does trial NCT05176418 study?

This clinical trial studies the following conditions: Nicotine Dependence.

What interventions are being tested in trial NCT05176418?

The interventions under investigation include: low dose Nicotine (DRUG), high dose Nicotine (DRUG).

Who is sponsoring clinical trial NCT05176418?

This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05176418 being conducted?

This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.