Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
NCT06077240 · View on ClinicalTrials.gov ↗
Study Summary
The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products. Participants will be randomized to receive either e-cigarettes or nicotine pouches for a duration of 4 weeks and to 1 of 4 possible regulatory scenarios within products where flavor availability is either menthol and tobacco/unflavored available or tobacco/unflavored only available, and nicotine concentration is either higher (5% e-cig, 6mg pouch) or lower (2.4% e-cig, 3mg pouch). Participants will return for bi-weekly research visits (in person or remote videocall) to complete measures for study aims. Participants will complete a final follow-up at Week 6 to assess maintenance of cigarette reduction and willingness to continue using products once they are no longer provided. The investigators expect to observe which products and constituents lead to greater smoking reduction.
Conditions Studied
Interventions
- BEHAVIORAL E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors
- BEHAVIORAL E-cigarette with 2.4% Nicotine with Tobacco Flavor Only
- BEHAVIORAL E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors
- BEHAVIORAL E-cigarette with 5% Nicotine with Tobacco Flavor Only
- BEHAVIORAL Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors
Study Locations (1)
Connecticut
- Yale University — New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 256 participants |
| Start Date | 2024-08-20 |
| Est. Completion | 2028-04-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06077240
The ClinicalTrials.gov registry entry for NCT06077240 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 256 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Yale University, which has 1,283 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Smoking appearing as the primary indexed condition, and to 5 interventions — of which E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06077240 reports 1 study location spanning 1 distinct geographic area — top geographies include Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06077240 about?
NCT06077240 is a clinical study titled "Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction". The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products. Participants will be randomized to receive either e-cigarettes or nicotine pouches for a duration of 4 weeks and to 1 of 4 possible regu...
What is the current status of trial NCT06077240?
This trial is currently recruiting. It is a NA study. The enrollment target is 256 participants. The study started on 2024-08-20. Estimated completion is 2028-04-01.
What conditions does trial NCT06077240 study?
This clinical trial studies the following conditions: Smoking, Nicotine Dependence, Smoking Behaviors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06077240?
The interventions under investigation include: E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors (BEHAVIORAL), E-cigarette with 2.4% Nicotine with Tobacco Flavor Only (BEHAVIORAL), E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors (BEHAVIORAL), E-cigarette with 5% Nicotine with Tobacco Flavor Only (BEHAVIORAL), Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors (BEHAVIORAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06077240?
This trial is sponsored by Yale University, which has 1,283 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06077240 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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