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NCT06077240 · ClinicalTrials.gov registry record · NA
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
A NA study of Smoking and Nicotine Dependence, sponsored by Yale University.
- Recruiting
- Registry status
- NA
- Development phase
- 256
- Enrollment target
- 1
- Study location
NCT06077240: Recruiting NA study of Smoking and Nicotine Dependence, sponsored by Yale University.
NCT06077240 is a NA study of Smoking and Nicotine Dependence that is actively recruiting participants, run by Yale University. The registered enrollment target is 256 participants, below the 453-participant average among 123 other Smoking trials with a reported enrollment target (43% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06077240, a NA study of Smoking and Nicotine Dependence, is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- NA
- Development phase
- 256 participants
- Enrollment target
- 1
- Study location
Study Summary
The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products. Participants will be randomized to receive either e-cigarettes or nicotine pouches for a duration of 4 weeks and to 1 of 4 possible regulatory scenarios within products where flavor availability is either menthol and tobacco/unflavored available or tobacco/unflavored only available, and nicotine concentration is either higher (5% e-cig, 6mg pouch) or lower (2.4% e-cig, 3mg pouch). Participants will return for bi-weekly research visits (in person or remote videocall) to complete measures for study aims. Participants will complete a final follow-up at Week 6 to assess maintenance of cigarette reduction and willingness to continue using products once they are no longer provided. The investigators expect to observe which products and constituents lead to greater smoking reduction.
Primary Outcome
Participants will report the total number of cigarettes consumed each day using a well-validated timeline follow-back (TLFB) interview method to assess number of cigarettes smoked per day continuously over the 4-week observational period for each product condition.
Conditions Studied
Interventions
- BEHAVIORAL E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors
- BEHAVIORAL E-cigarette with 2.4% Nicotine with Tobacco Flavor Only
- BEHAVIORAL E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors
- BEHAVIORAL E-cigarette with 5% Nicotine with Tobacco Flavor Only
- BEHAVIORAL Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors
Study Locations (1)
Connecticut
- Yale University - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 256 participants |
| Start Date | 2024-08-20 |
| Est. Completion | 2028-04-01 |
| Phase | NA |
What NCT06077240 shows while recruiting
NCT06077240 is an interventional study that assigns participants to a tested intervention. The registered 256 participants enrollment target is mid-sized for trials with a published cap, below the 453-participant average among 123 other Smoking trials with a reported enrollment target (43% lower).
The record links to 3 conditions, with Smoking appearing as the primary indexed condition, and to 5 interventions - of which E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors is the first listed.
NCT06077240 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT06077240 about?
NCT06077240 is a clinical study titled "Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction". The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products. Participants will be randomized to receive either e-cigarettes or nicotine pouches for a duration of 4 weeks and to 1 of 4 possible regu...
What is the current status of trial NCT06077240?
This trial is currently recruiting. It is a NA study. The enrollment target is 256 participants. The study started on 2024-08-20. Estimated completion is 2028-04-01.
What conditions does trial NCT06077240 study?
This clinical trial studies the following conditions: Smoking, Nicotine Dependence, Smoking Behaviors.
What interventions are being tested in trial NCT06077240?
The interventions under investigation include: E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors (BEHAVIORAL), E-cigarette with 2.4% Nicotine with Tobacco Flavor Only (BEHAVIORAL), E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors (BEHAVIORAL), E-cigarette with 5% Nicotine with Tobacco Flavor Only (BEHAVIORAL), Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors (BEHAVIORAL).
Who is sponsoring clinical trial NCT06077240?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06077240 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Smoking
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06077240's enrollment target sits among peer trials
256 48th of 123 higher than 76 of 123 other Smoking trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Smoking trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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