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NCT01037153 · ClinicalTrials.gov registry record
Effects of Nicotine on Brain Activity as Measured by fMRI
A clinical trial of Nicotine Dependence and Drug Abuse, sponsored by National Institute on Drug Abuse (NIDA).
- Completed
- Registry status
- 128
- Enrollment target
- 1
- Study location
NCT01037153: Completed study of Nicotine Dependence and Drug Abuse, sponsored by National Institute on Drug Abuse (NIDA).
NCT01037153 is a study of Nicotine Dependence and Drug Abuse that has completed, run by National Institute on Drug Abuse (NIDA). The registered enrollment target is 128 participants, below the 185-participant average among 67 other Nicotine Dependence trials with a reported enrollment target (31% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01037153, a study of Nicotine Dependence and Drug Abuse, has completed, sponsored by National Institute on Drug Abuse (NIDA).
- COMPLETED
- Registry status
- 128 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: \- Nicotine addiction is common among people who smoke tobacco, and the addictive properties of nicotine make smoking cessation difficult even for people who want to quit. Research has shown that smoking causes changes in the brain that lead to addiction and craving, but more research is needed to determine how different doses of nicotine and different intervals of receiving nicotine affect brain function. A greater understanding of nicotine's effect on the brain, as studied through functional magnetic resonance imaging (fMRI), may improve the effectiveness of smoking cessation therapies and treatments. Objectives: \- To determine the effects of nicotine on brain function and chemistry in experienced cigarette smokers. Eligibility: \- Current smokers (at least 20 cigarettes per day for at least 1 year) between 18 and 50 years of age. Design: * The study involves five separate research experiments. Most participants will be involved in only one experiment. * The experiments will evaluate brain activity and function using fMRI. Participants will be trained in a series of tests on cognitive function before beginning the experimental part of the study. * Experiment 1: Participants will have three fMRI scan sessions after receiving different dose levels of intravenous nicotine. * Experiment 2: Participants will have four fMRI scan sessions after receiving two doses of nicotine separated by 1/4, 1/2, 3, and 24 hours. * Experiment 3: Participants will have two sets of nicotine injections separated by 45 minutes, with each injection series containing five rapid injections of small amounts of nicotine (to mimic five puffs on a cigarette). * Experiment 4: Participants will have three fMRI sessions after receiving a single injection of nicotine at three different rates (over 15, 60, or 120 seconds). In addition there will be three more sessions involving a nicotine patch and a nicotine injection as well as a placebo session. * Experiment 5: Participants will
Conditions Studied
Study Locations (1)
Maryland
- National Institute on Drug Abuse, Biomedical Research Center (BRC) - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 128 participants |
| Start Date | 2002-08-06 |
| Est. Completion | 2011-07-25 |
What the finished NCT01037153 record still lists
NCT01037153 is an observational study that tracks outcomes without assigning an intervention. The registered 128 participants enrollment target is mid-sized for trials with a published cap, below the 185-participant average among 67 other Nicotine Dependence trials with a reported enrollment target (31% lower).
The record links to 2 conditions, with Nicotine Dependence appearing as the primary indexed condition, and to 0 interventions.
NCT01037153 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT01037153 about?
NCT01037153 is a clinical study titled "Effects of Nicotine on Brain Activity as Measured by fMRI". Background: \- Nicotine addiction is common among people who smoke tobacco, and the addictive properties of nicotine make smoking cessation difficult even for people who want to quit. Research has shown that smoking causes changes in the brain that lead to addiction and craving, but more research i...
What is the current status of trial NCT01037153?
This trial is currently completed. The enrollment target is 128 participants. The study started on 2002-08-06. Estimated completion is 2011-07-25.
What conditions does trial NCT01037153 study?
This clinical trial studies the following conditions: Nicotine Dependence, Drug Abuse.
Who is sponsoring clinical trial NCT01037153?
This trial is sponsored by National Institute on Drug Abuse (NIDA), which has 335 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01037153 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Nicotine Dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01037153's enrollment target sits among peer trials
128 28th of 67 higher than 40 of 67 other Nicotine Dependence trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Nicotine Dependence trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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