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ClinicalTrials.gov 16 recruiting now official registry

Atherosclerosis clinical trials

16 of 70 indexed Atherosclerosis trials are currently recruiting.

70 US clinical trials · 16 currently recruiting

Atherosclerosis is the subject of 70 registered US clinical trials on ClinicalTrials.gov, 16 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is National Heart, Lung, and Blood Institute (NHLBI), running 12 of these trials.

The research picture

Atherosclerosis has 70 registered US clinical trials, 16 of them open to new participants right now, about 23% of the total.

16
recruiting participants now
23%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
12
top sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Phase 14Phase 211Phase 35Phase 48

Active & Recent Trials

70 total, page 1 of 2

RECRUITING Phase 4 7,410 participants

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

VA Office of Research and Development

NCT02915198

RECRUITING 5,000 participants

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

National Heart, Lung, and Blood Institute (NHLBI)

NCT01143454

RECRUITING NA 4,000 participants

New Heart Imaging Techniques to Evaluate Possible Heart Disease

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT01399385

RECRUITING 2,000 participants

Causes and Natural History of Dyslipidemias

National Heart, Lung, and Blood Institute (NHLBI)

NCT00353782

RECRUITING 1,500 participants

Natural History of Uncommon Dyslipidemias, Rare Lipid Disorders and Unusual Atherosclerotic Conditions

National Heart, Lung, and Blood Institute (NHLBI)

NCT06676046

RECRUITING 725 participants

Study of the Effect of Innate on the Inflammatory Response to Endotoxin

National Institute of Environmental Health Sciences (NIEHS)

NCT01143480

RECRUITING NA 260 participants

Text Education About Cardiovascular Health and HIV (TEACH-HIV)

University of California, San Francisco

NCT05642858

RECRUITING 180 participants

Machine Learning for Handheld Vascular Studies

Duke University

NCT02932176

RECRUITING Phase 2 130 participants

Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders Trial

Wake Forest University Health Sciences

NCT06488105

RECRUITING Phase 2 121 participants

Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)

Priscilla Hsue, MD

NCT05488431

RECRUITING Phase 4 120 participants

Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT

Matthew J. Budoff

NCT05708859

RECRUITING NA 112 participants

Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History

University of Southern California

NCT05867381

RECRUITING NA 36 participants

The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease

Massachusetts General Hospital

NCT04505865

RECRUITING NA 33 participants

PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]

Johns Hopkins University

NCT05994014

RECRUITING NA 30 participants

Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

Massachusetts General Hospital

NCT04496947

RECRUITING NA 24 participants

High Protein Diet and Atherosclerosis

University of Missouri-Columbia

NCT05235464

ACTIVE NOT RECRUITING 11,737 participants

Bogalusa Heart Study

Tulane University

NCT00005129

ACTIVE NOT RECRUITING 5,306 participants

The Jackson Heart Study of Cardiovascular Disease Among African Americans

National Heart, Lung, and Blood Institute (NHLBI)

NCT00005485

ACTIVE NOT RECRUITING NA 3,100 participants

IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact

Medstar Health Research Institute

NCT04221815

ACTIVE NOT RECRUITING 2,314 participants

Mediators of Atherosclerosis in South Asians Living in America

University of California, San Francisco

NCT01207167

ACTIVE NOT RECRUITING NA 1,085 participants

Century Trial, a Randomized Lifestyle Modification Study for Management of Stable Coronary Artery Disease

The University of Texas Health Science Center, Houston

NCT00756379

ACTIVE NOT RECRUITING 1,000 participants

Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration

Massachusetts General Hospital

NCT04523194

ACTIVE NOT RECRUITING Phase 2 385 participants

Advancing Postmenopausal Preventive Therapy

University of Southern California

NCT04103476

ACTIVE NOT RECRUITING NA 10 participants

Leucine, MTOR and Athero

University of Missouri-Columbia

NCT05470218

COMPLETED Phase 3 10,251 participants

Action to Control Cardiovascular Risk in Diabetes (ACCORD)

National Heart, Lung, and Blood Institute (NHLBI)

NCT00000620

COMPLETED 2,763 participants

Understanding the Genetic and Hereditary Basis of Atherosclerosis

Wake Forest University Health Sciences

NCT00344292

COMPLETED 1,888 participants

Genetic Factors in Atherosclerosis

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00359307

COMPLETED Phase 3 1,743 participants

12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With Ezetimibe

AstraZeneca

NCT00525824

COMPLETED 1,501 participants

PLATINUM Diversity

Boston Scientific Corporation

NCT02240810

COMPLETED 886 participants

Non-Invasive Imaging of Atherosclerosis

Icahn School of Medicine at Mount Sinai

NCT01418313

COMPLETED Phase 4 782 participants

Effect of Evolocumab on Saphenous Vein Graft Patency Following Coronary Artery Bypass Surgery

Unity Health Toronto

NCT03900026

COMPLETED 752 participants

Examining the Genetic Predictors of Coronary Artery Calcification in African Americans

University of Michigan

NCT00925561

COMPLETED Phase 3 440 participants

RANGER™ Paclitaxel Coated Balloon vs Standard Balloon Angioplasty

Boston Scientific Corporation

NCT03064126

COMPLETED Phase 4 355 participants

Improving Cardiovascular Risk Prediction Using Hand Held Carotid Ultrasonography Study

University of Wisconsin, Madison

NCT00574457

COMPLETED Phase 2 353 participants

VEAPS: Vitamin E Atherosclerosis Prevention Study

National Institute on Aging (NIA)

NCT00114387

COMPLETED NA 328 participants

The OMEGA Clinical Trial

Boston Scientific Corporation

NCT01419171

COMPLETED 324 participants

Plaque Inflammation and Dysfunctional HDL in AIM-HIGH

University of Washington

NCT00880178

COMPLETED Phase 4 308 participants

Testosterone Replacement in Older Men and Atherosclerosis Progression

Brigham and Women's Hospital

NCT00287586

COMPLETED Phase 2 289 participants

Safety and Efficacy Study of Ad2/Hypoxia Inducible Factor (HIF)-1α/VP16 Gene Transfer in Patients With Intermittent Claudication

Genzyme, a Sanofi Company

NCT00117650

COMPLETED Phase 2 270 participants

Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women

National Heart, Lung, and Blood Institute (NHLBI)

NCT00666172

COMPLETED Phase 2 270 participants

MARS - Monitored Atherosclerosis Regression Study

Merck Sharp & Dohme

NCT00116870

COMPLETED Phase 3 269 participants

Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) as Add-on to Ezetimibe Therapy in Patients With Elevated LDL-C (CLEAR Tranquility)

Esperion Therapeutics

NCT03001076

COMPLETED NA 230 participants

The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD

University of West Florida

NCT04089943

COMPLETED Phase 4 230 participants

Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression

National Heart, Lung, and Blood Institute (NHLBI)

NCT01212900

COMPLETED 216 participants

New Technologies to Determine Carotid Plaque Vulnerability

Mayo Clinic

NCT02224339

COMPLETED 209 participants

Study of the Interaction Between the Cells Lining Blood Vessels and Angiotensin-Converting Enzyme

National Heart, Lung, and Blood Institute (NHLBI)

NCT00001461

COMPLETED NA 184 participants

Comparing TR Band to Statseal in Conjunction With TR Band

VA Long Beach Healthcare System

NCT03028025

COMPLETED NA 182 participants

A Web-based Approach to Treating Cardiovascular Disease Risk in Employees With Metabolic Syndrome

Baptist Health South Florida

NCT01912209

COMPLETED 170 participants

Individualized Comprehensive Atherosclerosis Risk-reduction Evaluation Program

Piedmont Healthcare

NCT00969865

COMPLETED 167 participants

Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers

University of Miami

NCT00253682

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Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 11
Phase 3 5
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Atherosclerosis Trial Landscape

70 indexed Atherosclerosis studies · 16 recruiting (23%).

Phase mix: 13 late (III/IV) vs 15 early (I/II).

Top sponsor: National Heart, Lung, and Blood Institute (NHLBI) (12 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Atherosclerosis?

PlainTrial tracks 70 US clinical trials for Atherosclerosis, of which 16 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Atherosclerosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.