Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Atherosclerosis clinical trials
16 of 70 indexed Atherosclerosis trials are currently recruiting.
70 US clinical trials · 16 currently recruiting
Atherosclerosis is the subject of 70 registered US clinical trials on ClinicalTrials.gov, 16 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is National Heart, Lung, and Blood Institute (NHLBI), running 12 of these trials.
The research picture
Atherosclerosis has 70 registered US clinical trials, 16 of them open to new participants right now, about 23% of the total.
- 16
- recruiting participants now
- 23%
- of trials open to enrollment
- 13
- in Phase 3–4 (later-stage)
- 12
- top sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Active & Recent Trials
70 total, page 1 of 2
Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
VA Office of Research and Development
NCT02915198
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
National Heart, Lung, and Blood Institute (NHLBI)
NCT01143454
New Heart Imaging Techniques to Evaluate Possible Heart Disease
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT01399385
Causes and Natural History of Dyslipidemias
National Heart, Lung, and Blood Institute (NHLBI)
NCT00353782
Natural History of Uncommon Dyslipidemias, Rare Lipid Disorders and Unusual Atherosclerotic Conditions
National Heart, Lung, and Blood Institute (NHLBI)
NCT06676046
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
National Institute of Environmental Health Sciences (NIEHS)
NCT01143480
Text Education About Cardiovascular Health and HIV (TEACH-HIV)
University of California, San Francisco
NCT05642858
Machine Learning for Handheld Vascular Studies
Duke University
NCT02932176
Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders Trial
Wake Forest University Health Sciences
NCT06488105
Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)
Priscilla Hsue, MD
NCT05488431
Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT
Matthew J. Budoff
NCT05708859
Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History
University of Southern California
NCT05867381
The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease
Massachusetts General Hospital
NCT04505865
PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]
Johns Hopkins University
NCT05994014
Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study
Massachusetts General Hospital
NCT04496947
High Protein Diet and Atherosclerosis
University of Missouri-Columbia
NCT05235464
Bogalusa Heart Study
Tulane University
NCT00005129
The Jackson Heart Study of Cardiovascular Disease Among African Americans
National Heart, Lung, and Blood Institute (NHLBI)
NCT00005485
IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
Medstar Health Research Institute
NCT04221815
Mediators of Atherosclerosis in South Asians Living in America
University of California, San Francisco
NCT01207167
Century Trial, a Randomized Lifestyle Modification Study for Management of Stable Coronary Artery Disease
The University of Texas Health Science Center, Houston
NCT00756379
Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration
Massachusetts General Hospital
NCT04523194
Advancing Postmenopausal Preventive Therapy
University of Southern California
NCT04103476
Leucine, MTOR and Athero
University of Missouri-Columbia
NCT05470218
Action to Control Cardiovascular Risk in Diabetes (ACCORD)
National Heart, Lung, and Blood Institute (NHLBI)
NCT00000620
Understanding the Genetic and Hereditary Basis of Atherosclerosis
Wake Forest University Health Sciences
NCT00344292
Genetic Factors in Atherosclerosis
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00359307
12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With Ezetimibe
AstraZeneca
NCT00525824
PLATINUM Diversity
Boston Scientific Corporation
NCT02240810
Non-Invasive Imaging of Atherosclerosis
Icahn School of Medicine at Mount Sinai
NCT01418313
Effect of Evolocumab on Saphenous Vein Graft Patency Following Coronary Artery Bypass Surgery
Unity Health Toronto
NCT03900026
Examining the Genetic Predictors of Coronary Artery Calcification in African Americans
University of Michigan
NCT00925561
RANGER™ Paclitaxel Coated Balloon vs Standard Balloon Angioplasty
Boston Scientific Corporation
NCT03064126
Improving Cardiovascular Risk Prediction Using Hand Held Carotid Ultrasonography Study
University of Wisconsin, Madison
NCT00574457
VEAPS: Vitamin E Atherosclerosis Prevention Study
National Institute on Aging (NIA)
NCT00114387
The OMEGA Clinical Trial
Boston Scientific Corporation
NCT01419171
Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
University of Washington
NCT00880178
Testosterone Replacement in Older Men and Atherosclerosis Progression
Brigham and Women's Hospital
NCT00287586
Safety and Efficacy Study of Ad2/Hypoxia Inducible Factor (HIF)-1α/VP16 Gene Transfer in Patients With Intermittent Claudication
Genzyme, a Sanofi Company
NCT00117650
Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women
National Heart, Lung, and Blood Institute (NHLBI)
NCT00666172
MARS - Monitored Atherosclerosis Regression Study
Merck Sharp & Dohme
NCT00116870
Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) as Add-on to Ezetimibe Therapy in Patients With Elevated LDL-C (CLEAR Tranquility)
Esperion Therapeutics
NCT03001076
The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD
University of West Florida
NCT04089943
Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression
National Heart, Lung, and Blood Institute (NHLBI)
NCT01212900
New Technologies to Determine Carotid Plaque Vulnerability
Mayo Clinic
NCT02224339
Study of the Interaction Between the Cells Lining Blood Vessels and Angiotensin-Converting Enzyme
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001461
Comparing TR Band to Statseal in Conjunction With TR Band
VA Long Beach Healthcare System
NCT03028025
A Web-based Approach to Treating Cardiovascular Disease Risk in Employees With Metabolic Syndrome
Baptist Health South Florida
NCT01912209
Individualized Comprehensive Atherosclerosis Risk-reduction Evaluation Program
Piedmont Healthcare
NCT00969865
Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers
University of Miami
NCT00253682
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 11 |
| Phase 3 | 5 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Atherosclerosis Trial Landscape
70 indexed Atherosclerosis studies · 16 recruiting (23%).
Phase mix: 13 late (III/IV) vs 15 early (I/II).
Top sponsor: National Heart, Lung, and Blood Institute (NHLBI) (12 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Atherosclerosis?
PlainTrial tracks 70 US clinical trials for Atherosclerosis, of which 16 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Atherosclerosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.