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NCT01505725 · ClinicalTrials.gov registry record
Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms
A clinical trial of Nicotine Dependence, sponsored by National Institute on Drug Abuse (NIDA).
- Completed
- Registry status
- 92
- Enrollment target
- 1
- Study location
NCT01505725: Completed study of Nicotine Dependence, sponsored by National Institute on Drug Abuse (NIDA).
NCT01505725 is a study of Nicotine Dependence that has completed, run by National Institute on Drug Abuse (NIDA). The registered enrollment target is 92 participants, below the 185-participant average among 67 other Nicotine Dependence trials with a reported enrollment target (50% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01505725, a study of Nicotine Dependence, has completed, sponsored by National Institute on Drug Abuse (NIDA).
- COMPLETED
- Registry status
- 92 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: \- Researchers have been studying behavioral components of nicotine addiction by looking at how drugs have a reinforcing effect, connecting the stimulation provided by the drug (nicotine) to the behavior that produces it (smoking). Based on previous studies, researchers are interested in learning more about how nicotine affects current smokers' responses to psychological tests and smoking-related cues, and in studying whether certain kinds of genetic background may affect smokers' responses to these kinds of studies. Objectives: * To compare the effect of nicotine versus denicotinized cigarettes during specific psychological tests. * To compare the effects of smoking cues versus neutral cues on craving, mood, and autonomic response. * To study the effect of genes on nicotine reinforcement and smoking-cue reactivity. Eligibility: \- Individuals between 18 and 64 years of age who are current smokers (at least 10 cigarettes per day for at least 1 year) and are not currently interested in reducing their smoking or seeking treatment for tobacco dependence. Design: * Pilot session: * Participants will practice smoking using the measuring equipment that will be used in the study. * After successful practice, participants will read or listen to music for 1 hour, during which they are not allowed to smoke. * After the 1-hour period, participants will sample study cigarettes that have different levels of nicotine, and will be asked to guess whether the cigarettes are normal study cigarettes or denicotinized cigarettes. * Baseline session: * Blood, urine, and breath samples will be taken at the start of the session. * Participants will smoke part of an initial cigarette, and then will read or listen to music for 1 hour, during which they are not allowed to smoke. * After the 1-hour period, participants will give another breath sample and will complete questionnaires about mood and concentration levels. * Trial sessions: * Participants will smoke study cigare
Conditions Studied
Study Locations (1)
Maryland
- National Institute on Drug Abuse, Biomedical Research Center (BRC) - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 92 participants |
| Start Date | 2010-03-16 |
| Est. Completion | 2013-11-29 |
What the finished NCT01505725 record still lists
NCT01505725 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 92 participants, a relatively small participant target, below the 185-participant average among 67 other Nicotine Dependence trials with a reported enrollment target (50% lower).
The record links to 1 condition, with Nicotine Dependence appearing as the primary indexed condition, and to 0 interventions.
NCT01505725 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT01505725 about?
NCT01505725 is a clinical study titled "Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms". Background: \- Researchers have been studying behavioral components of nicotine addiction by looking at how drugs have a reinforcing effect, connecting the stimulation provided by the drug (nicotine) to the behavior that produces it (smoking). Based on previous studies, researchers are interested i...
What is the current status of trial NCT01505725?
This trial is currently completed. The enrollment target is 92 participants. The study started on 2010-03-16. Estimated completion is 2013-11-29.
What conditions does trial NCT01505725 study?
This clinical trial studies the following conditions: Nicotine Dependence.
Who is sponsoring clinical trial NCT01505725?
This trial is sponsored by National Institute on Drug Abuse (NIDA), which has 335 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01505725 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Nicotine Dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01505725's enrollment target sits among peer trials
92 37th of 67 higher than 31 of 67 other Nicotine Dependence trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Nicotine Dependence trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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