National Institute on Drug Abuse (NIDA)
National Institute on Drug Abuse (NIDA) sponsors 335 registered US clinical trials on ClinicalTrials.gov, 14 of them currently recruiting, and 292 completed. 30 of these trials are in Phase 3-4 (later-stage) and 202 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Cocaine-Related Disorders, with 17 trials.
Trial Pipeline
335 total, page 1 of 7
Environment and Alcohol: A Pilot Study
NCT06860607
Developing Transcranial Neuromodulation Protocols for Learning and Decision-Making
NCT06561828
SMART-r: Substance Monitoring and Active Relapse Tracking Repository
NCT06676059
Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP
NCT06552741
Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder
NCT06233799
Semaglutide Therapy for Alcohol Reduction (STAR)
NCT06015893
Spironolactone in Alcohol Use Disorder (SAUD)
NCT05807139
Development and Validation of Learning and Decision-Making Tasks
NCT05707806
Orexin s Role in the Neurobiology of Substance Use Disorder
NCT05630781
Defining Neurobiological Links Between Substance Use and Mental Illness
NCT05538910
Evaluation of the Interactions of Cannabidiol (CBD) With Morphine
NCT05143424
Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder
NCT03745339
Mechanism of Non-invasive Magnetic Stimulation
NCT03394066
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
NCT01036581
Phase 1 Study of Oral MG001
NCT07204171
VK4-116 Phase I Study With Food-Effect
NCT06808932
Olfactory Function and Model-Based Behavior in People Living With HIV and SUD
NCT07637669
Causal Mechanisms of Odor-Guided Behavior in Humans
NCT07099092
Phase I Trial of High-Density Theta Burst Stimulation (hdTBS)
NCT06868914
Hippocampal Network Changes Following Mindfulness Training in Tobacco Vaping Adolescents in an Open-label, Pilot Study
NCT06503159
SXC-2023 Cocaine Interaction Study
NCT06343532
Adolescent Vaping Characterization and Parent Views on Adolescent Vaping Protocol
NCT05669716
Real-world Momentary Assessment of Kratom Use Accompanied by Product Assays: A Natural-history Study for Interdisciplinary Characterization of Kratom Use and Pharmacology
NCT05457803
Biased Opioid Agonists for Treatment of Opioid Withdrawal in OUD
NCT04316559
Manipulating Ghrelin Signaling Via GOAT Inhibition in Alcohol Use Disorder
NCT03896516
Just-In-Time Adaptive Interventions for Addictive Behaviors
NCT03538652
Imaging Biomarker for Addiction Treatment Outcome
NCT03427424
Comparison of Naloxone Pharmacokinetics
NCT03386591
Lorcaserin in the Treatment of Cocaine Use Disorder
NCT03007394
Evaluation of the Effects of Cannabidiol (CBD) Compared to Delta-9-Tetrahydrocannabinol (THC) and Alprazolam
NCT03398083
Exploring Gut-Brain and Brain-Gut Interactions in Alcohol Use Disorder Via Microbiota Investigations: A Pilot Study
NCT03152760
Pharmacokinetic Evaluation of Nalmefene Administered Intranasally to Healthy Volunteers
NCT03129347
Effects of a New Behavioral Intervention on Alcohol Craving and Drinking
NCT02831049
Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use
NCT02927236
Pharmacokinetic Evaluation of Intranasal, Intramuscular, and Oral Naltrexone in Healthy Volunteers
NCT02750748
The Study of AZD8529 for Smoking Cessation in Female Smokers
NCT02401022
Study to Assess Potential Interactions Between Intravenous Cocaine and Oral Lorcaserin
NCT02393599
Pharmacokinetic Evaluation of Intranasal and Intramuscular Naloxone in Healthy Volunteers
NCT02572089
Repetitive Transcranial Magnetic Stimulation Equipment Testing and Pilot Study
NCT02231892
Impact of Delta Opioid Receptor Gene (OPRD1) Variations on Treatment Outcome in African Americans
NCT02225184
Effects of Cannabis Administration Routes on Human Performance and Pharmacokinetics
NCT02177513
Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity
NCT01867411
Brain Networks and Addiction Susceptibility
NCT01924468
Nicotine Withdrawal Symptoms and Smoking Relapse
NCT01511614
Laboratory Study of Cannabidiol on the Effects of Smoked Marijuana
NCT01844687
A Multi-Center Trial of Nepicastat for Cocaine Dependence
NCT01704196
Three Strategies for Implementing Motivational Interviewing on Medical Inpatient Units
NCT01825057
Interactions Between Intravenous Cocaine and Acetazolamide or Quinine
NCT01851473
Studying Nicotine Addiction With Transcranial Magnetic Stimulation
NCT01702948
Factors Affecting Methamphetamine and Opiates Drug Testing
NCT01736332
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 81 |
| Phase 2 | 121 |
| Phase 3 | 14 |
| Phase 4 | 16 |
What the Pipeline for National Institute on Drug Abuse (NIDA) Shows
According to the ClinicalTrials.gov registry, National Institute on Drug Abuse (NIDA) is linked to 335 US clinical trials across every stage of research activity. Of those, 14 studies are currently recruiting, about 4% of the sponsor's indexed portfolio, and 292 are already marked complete, representing roughly 87% of the total.
The phase mix for National Institute on Drug Abuse (NIDA) reports 30 late-stage studies (Phase 3 and Phase 4 combined) and 202 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for National Institute on Drug Abuse (NIDA) is Cocaine-Related Disorders with 17 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.