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ClinicalTrials.gov 45 recruiting now official registry

Metastatic Castration-Resistant Prostate Cancer clinical trials

45 of 70 indexed Metastatic Castration-Resistant Prostate Cancer trials are currently recruiting.

70 US clinical trials · 45 currently recruiting

Metastatic Castration-Resistant Prostate Cancer is the subject of 70 registered US clinical trials on ClinicalTrials.gov, 45 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 60 in Phase 1-2 (earlier-stage). The most active sponsor is University of Utah, running 5 of these trials.

The research picture

Metastatic Castration-Resistant Prostate Cancer has 70 registered US clinical trials, 45 of them open to new participants right now, about 64% of the total.

45
recruiting participants now
64%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
5
top sponsor: University of Utah
Phase 133Phase 227Phase 38Phase 41

Active & Recent Trials

70 total, page 1 of 2

RECRUITING Phase 1 1,200 participants

Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)

Merck Sharp & Dohme

NCT02861573

RECRUITING Phase 3 960 participants

A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer

Celgene

NCT06764485

RECRUITING Phase 3 900 participants

A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

Pfizer

NCT06629779

RECRUITING Phase 3 750 participants

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

Amgen

NCT07213674

RECRUITING Phase 3 675 participants

Phase 3 Study of Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Participants With Progressive Metastatic Castration-Resistant Prostate Cancer (XALute)

Amgen

NCT06691984

RECRUITING Phase 2 454 participants

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

AstraZeneca

NCT05489211

RECRUITING Phase 3 430 participants

The Study of 177Lu-TLX591 Plus SOC Versus SOC Alone in Patients With mCRPC (ProstACT Global)

Telix Pharmaceuticals (Innovations) Pty Limited

NCT06520345

RECRUITING Phase 1 370 participants

A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With Cemiplimab or REGN5678 for Adult Participants With Advanced Prostate Cancer

Regeneron Pharmaceuticals

NCT05125016

RECRUITING Phase 1 275 participants

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

Novartis Pharmaceuticals

NCT04104776

RECRUITING Phase 1 272 participants

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

Janux Therapeutics

NCT05519449

RECRUITING Phase 2 218 participants

A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer

Astellas Pharma Global Development

NCT07005154

RECRUITING Phase 1 205 participants

Study of GVV858 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

Novartis Pharmaceuticals

NCT07288359

RECRUITING Phase 2 200 participants

ZEN003694 and Enzalutamide Versus Enzalutamide Monotherapy in Metastatic Castration-Resistant Prostate Cancer

Zenith Epigenetics

NCT04986423

RECRUITING Phase 1 174 participants

A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer

Astellas Pharma Global Development

NCT04729114

RECRUITING Phase 1 144 participants

A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)

K36 Therapeutics

NCT07103018

RECRUITING Phase 1 140 participants

A Study to Assess Adverse Events, and How Intravenously (IV) Infused ABBV-969 Moves Through the Bodies of Adult Participants With Metastatic Castration-Resistant Prostate Cancer

AbbVie

NCT06318273

RECRUITING Phase 1 140 participants

A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer

Bristol-Myers Squibb

NCT06067841

RECRUITING Phase 1 106 participants

A Study of Radiation Dosimetry, Safety, and Tolerability of Extended Lutetium (177Lu) Vipivotide Tetraxetan Treatment in Chemo-naïve Adults With Metastatic Castration-resistant Prostate Cancer: RADIOpharmaceutical DOSimetry Evaluation (RADIODOSE) Study

Novartis Pharmaceuticals

NCT06531499

RECRUITING Phase 2 100 participants

A Study to Test Inavolisib Treatment in Participants With Metastatic Castration-Resistant Prostate Cancer

Hoffmann-La Roche

NCT07287150

RECRUITING Phase 2 100 participants

FPI-2265 (225Ac-PSMA-I&T) for Patients With PSMA-Positive Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Fusion Pharmaceuticals

NCT06402331

RECRUITING Phase 1 95 participants

A Phase I Study of [225Ac]-AZD2284 in Patients With Metastatic Castration-Resistant Prostate Cancer

AstraZeneca

NCT06879041

RECRUITING Phase 1 91 participants

64Cu-GRIP B in Patients With Advanced Malignancies

Rahul Aggarwal

NCT05888532

RECRUITING Phase 1 82 participants

Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection

Blue Earth Therapeutics

NCT05413850

RECRUITING Phase 2 75 participants

A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Kyntra Bio

NCT06842498

RECRUITING Phase 2 70 participants

A Study of SYNC-T Therapy SV-102 in Participants With Metastatic Castration-Resistant Prostate Cancer

Syncromune

NCT06533644

RECRUITING Phase 2 60 participants

Supraphysiologic Testosterone Priming Induces Darolutamide Extended Response

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT07142551

RECRUITING Phase 1 60 participants

A Study of Valemetostat (DS-3201b) in Combination With Darolutamide in Metastatic Castration Resistant Prostate Cancer (mCRPC)

Daiichi Sankyo

NCT07244341

RECRUITING Phase 2 53 participants

Study of SX-682 Plus Enzalutamide in Men With ARPI-Resistant Metastatic Castration Resistant Prostate Cancer

Syntrix Biosystems

NCT06228053

RECRUITING Phase 1 50 participants

Study With [225Ac]Ac-FL-020 in mCRPC Participants

Full-Life Technologies

NCT06492122

RECRUITING Phase 2 50 participants

The COSMYC Trial (COmbined Suppression of MYC)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06922318

RECRUITING Phase 2 48 participants

Pembrolizumab Plus 177Lu-PSMA-617 in Patients With Castration Resistant Prostate Cancer

University of California, San Francisco

NCT05766371

RECRUITING Phase 2 44 participants

Cabazitaxel +/- Carboplatin vs 177Lu-PSMA-617 in Metastatic Castrate-resistant Prostate Cancer

Case Comprehensive Cancer Center

NCT06738303

RECRUITING Phase 1 40 participants

A Study of DS9051b in Participants With Advanced or Metastatic Adrenocortical Carcinoma and Metastatic Castration-resistant Prostate Cancer

Daiichi Sankyo

NCT07189403

RECRUITING Phase 2 40 participants

177Lu-PSMA-617 in Metastatic Castration Resistant Prostate Cancer (mCRPC) With Bone Marrow Involvement and Cytopenia

M.D. Anderson Cancer Center

NCT07025512

RECRUITING Phase 1 37 participants

LuCarbo - a Study of 177Lu-PSMA-617 Plus Carboplatin in Metastatic Castrate-resistant Prostate Cancer

Dana-Farber Cancer Institute

NCT06303713

RECRUITING Phase 1 33 participants

Dose-Escalation Study of Cabozantinib in Combination With Lutetium-177 (177Lu)-PSMA-617 in Patients With Metastatic Castration-Resistant Prostate Cancer

University of Utah

NCT05613894

RECRUITING Phase 2 32 participants

XL092 in Patients With Metastatic Castration-Resistant Prostate Cancer

University of Utah

NCT06568562

RECRUITING Phase 2 30 participants

Treatment of Patients With Progressive mCRPC With 177Lu-PSMA-617

Ebrahim S Delpassand

NCT06972628

RECRUITING Phase 4 30 participants

Pilot of 18F-DCFPyL-PSMA PET in mCRPC Patients Receiving 117Lu-Vipivotide Tetraxetan

Brigham and Women's Hospital

NCT06099093

RECRUITING Phase 1 30 participants

Autologous Gamma Delta T Cells to Target Prostate Stem Cell Antigen in mCRPC

H. Lee Moffitt Cancer Center and Research Institute

NCT06193486

RECRUITING Phase 1 30 participants

Abemaciclib Before 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer

Vadim S Koshkin

NCT05113537

RECRUITING Phase 2 26 participants

Sipuleucel-T Combined With Bipolar Androgen Therapy in Men With mCRPC

Yale University

NCT06100705

RECRUITING Phase 1 26 participants

[Lu-177]Ludotadipep in Castration-resistant Prostate Cancer(CRPC): Investigation of Drug and Application

FutureChem

NCT05458544

RECRUITING Phase 2 22 participants

Bortezomib in Patients With Metastatic Castration-Resistant Prostate Cancer With PTEN Deletion

University of Utah

NCT06029998

RECRUITING Phase 2 12 participants

Phase 2a Study of High-Dose Testosterone Followed by Radioligand Therapy in mCRPC

H. Lee Moffitt Cancer Center and Research Institute

NCT07476001

ACTIVE NOT RECRUITING Phase 3 895 participants

Study on Olaparib Plus Abiraterone as First-line Therapy in Men With Metastatic Castration-resistant Prostate Cancer

AstraZeneca

NCT03732820

ACTIVE NOT RECRUITING Phase 3 455 participants

Study Evaluating mCRPC Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment

POINT Biopharma, a wholly owned subsidiary of Eli Lilly and Company

NCT04647526

ACTIVE NOT RECRUITING Phase 1 325 participants

A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors

Exelixis

NCT03845166

ACTIVE NOT RECRUITING Phase 1 232 participants

A Study to Learn How Safe the Study Treatment Actinium-225-macropa-pelgifatamab (BAY3546828) is, How it Affects the Body, How it Moves Into, Through and Out of the Body, and About Its Anticancer Activity in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)

Bayer

NCT06052306

ACTIVE NOT RECRUITING Phase 1 148 participants

ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC

OncoC4

NCT05682443

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Phase Distribution

PhaseTrial count
Phase 1 33
Phase 2 27
Phase 3 8
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Castration-Resistant Prostate Cancer Trial Landscape

70 indexed Metastatic Castration-Resistant Prostate Cancer studies · 45 recruiting (64%).

Phase mix: 9 late (III/IV) vs 60 early (I/II).

Top sponsor: University of Utah (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Castration-Resistant Prostate Cancer?

PlainTrial tracks 70 US clinical trials for Metastatic Castration-Resistant Prostate Cancer, of which 45 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Castration-Resistant Prostate Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.