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2026 data Public-data reference. official source

Kidney Cancer

Open-data reference.

69 US clinical trials · 19 currently recruiting

Active & Recent Trials

RECRUITING 10,000 participants

International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors

Azienda Ospedaliero-Universitaria Careggi

NCT05363657

RECRUITING 5,950 participants

Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease

National Cancer Institute (NCI)

NCT00026884

RECRUITING 5,000 participants

Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders

National Cancer Institute (NCI)

NCT00001238

RECRUITING 1,130 participants

Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer

National Cancer Institute (NCI)

NCT00050752

RECRUITING NA 1,000 participants

Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)

University of California, San Francis

NCT05056077

RECRUITING 950 participants

Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer

National Cancer Institute (NCI)

NCT00033137

RECRUITING NA 600 participants

An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy

University of Texas Southwestern Medical Center

NCT04623502

RECRUITING 416 participants

Observational Basket Trial to Collect Tissue to Develop and Train a Live Tumor Diagnostic Platform

Elephas

NCT05520099

RECRUITING Phase 4 240 participants

Preop Laxatives in Robotic Urologic Surgery

Chad R. Tracy

NCT05805436

RECRUITING NA 220 participants

Designing Visual Tools to Enhance Cancer Surgeon Decision-making

UNC Lineberger Comprehensive Cancer Center

NCT06965192

RECRUITING Phase 2 110 participants

NSAID Use After Robotic Partial Nephrectomy

University of Miami

NCT05842044

RECRUITING NA 90 participants

Patient Navigation Program to Improve Clinical Trial Enrollment in Cancer Patients

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06138067

RECRUITING Phase 1 60 participants

A Study of VET3-TGI in Patients With Solid Tumors

KaliVir Immunotherapeutics

NCT06444815

RECRUITING Phase 2 48 participants

CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition

Mark Stein

NCT04322955

RECRUITING Phase 2 32 participants

Pre-NEOSHIFT-RCC: Neoadjuvant HIF-Inhibitor Immunotherapy in RCC

Dana-Farber Cancer Institute

NCT07397611

RECRUITING Phase 2 20 participants

Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03786796

RECRUITING Phase 2 17 participants

Neoadjuvant Pembrolizumab and Axitinib in Renal Cell Carcinoma With Inferior Vena Cava Tumor Thrombus

University of Colorado, Denver

NCT05969496

RECRUITING Phase 1 11 participants

Brodalumab in the Treatment of Immune-Related Adverse Events

Brian Henick, MD

NCT06673329

RECRUITING NA 10 participants

A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest

Dana-Farber Cancer Institute

NCT05899361

ACTIVE NOT RECRUITING NA 21,081 participants

Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients

Memorial Sloan Kettering Cancer Center

NCT00579514

ACTIVE NOT RECRUITING NA 603 participants

Adapting Multiple Behavior Interventions That Effectively Improve Cancer Survivor Health Cancer Survivor Health

University of Alabama at Birmingham

NCT04000880

ACTIVE NOT RECRUITING NA 240 participants

Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer

Vanderbilt University Medical Center

NCT04922307

ACTIVE NOT RECRUITING Phase 2 180 participants

Sequential Two-agent Assessment in Renal Cell Carcinoma Therapy: The START Trial

M.D. Anderson Cancer Center

NCT01217931

ACTIVE NOT RECRUITING NA 178 participants

Random Evaluation of Patients Who Have Had Laparoscopic Partial Nephrectomy

University of Chicago

NCT04120805

ACTIVE NOT RECRUITING 161 participants

KidneyCare Cohort Study (KCC-S)

University of Utah

NCT06898632

ACTIVE NOT RECRUITING NA 144 participants

Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Urologic Surgery (Expand URO)

Medtronic - MITG

NCT05696444

ACTIVE NOT RECRUITING Phase 1 140 participants

A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)

AstraZeneca

NCT00600496

ACTIVE NOT RECRUITING Phase 2 118 participants

A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)

Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT03634540

ACTIVE NOT RECRUITING Phase 1 110 participants

A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma (MK-3795-001)

Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT02293980

ACTIVE NOT RECRUITING NA 67 participants

The HistoSonics Edison™ System for Treatment of Primary Solid Renal Tumors Using Histotripsy (#HOPE4KIDNEY)

HistoSonics

NCT05820087

ACTIVE NOT RECRUITING Phase 1 57 participants

Study of Durvalumab and Guadecitabine in Advanced Kidney Cancer

Ajjai Alva, MD

NCT03308396

ACTIVE NOT RECRUITING Phase 1 39 participants

Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors

DEKA Biosciences

NCT05704985

ACTIVE NOT RECRUITING NA 35 participants

Integrated Actionable Aging Assessment for Cancer Patients Pilot

University of Colorado, Denver

NCT05871008

ACTIVE NOT RECRUITING Phase 2 24 participants

177LuPSMA in Renal Cell Carcinoma

Dana-Farber Cancer Institute

NCT06964958

ACTIVE NOT RECRUITING Phase 1 19 participants

NeoVax Plus Ipilimumab in Renal Cell Carcinoma

Patrick Ott, MD, PhD

NCT02950766

ACTIVE NOT RECRUITING Phase 2 18 participants

Perioperative Lenvatinib With Pembrolizumab in Patients With Locally Advanced Nonmetastatic Clear Cell Renal Cell Carcinoma

Emory University

NCT04393350

ACTIVE NOT RECRUITING Phase 1 17 participants

HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

National Heart, Lung, and Blood Institute (NHLBI)

NCT03354390

ACTIVE NOT RECRUITING Phase 2 9 participants

Study of Nivolumab in Combination With 177Lu-girentuximab for Kidney Cancer

Memorial Sloan Kettering Cancer Center

NCT05239533

COMPLETED 2,424 participants

Case-Control Study of Renal Cell Cancer Among Caucasions and African Americans in the United States

National Cancer Institute (NCI)

NCT00340457

COMPLETED Phase 3 250 participants

Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer

University of South Florida

NCT00369564

COMPLETED Phase 3 203 participants

Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors

Children's Oncology Group

NCT00002610

COMPLETED 122 participants

A Prospective Post-Market Study to Evaluate the Clinical Utility of IRIS, a Three-dimensional (3-D) Anatomical Modeling Software for Pre-operative Surgical Planning and Intra-operative Navigation for Nephrectomy

Intuitive Surgical

NCT04329767

COMPLETED Phase 2 119 participants

High-dose Bevacizumab in Advanced Renal Carcinoma Patients

SCRI Development Innovations

NCT00455975

COMPLETED Phase 1 97 participants

A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies

MedImmune

NCT02118337

COMPLETED Phase 2 60 participants

Sunitinib and Erlotinib in Treating Patients With Unresectable or Metastatic Kidney Cancer

OHSU Knight Cancer Institute

NCT00425386

COMPLETED Phase 2 60 participants

Sunitinib Scheduling in Metastatic Renal Cell Carcinoma (mRCC)

M.D. Anderson Cancer Center

NCT02060370

COMPLETED Phase 2 40 participants

Cyclophosphamide Plus Vaccine Therapy in Treating Patients With Advanced Cancer

St. Vincent Medical Center - Los Angeles

NCT00002475

COMPLETED Phase 2 39 participants

Neoadjuvant Axitinib in Locally Advanced Renal Cell Carcinoma (RCC)

M.D. Anderson Cancer Center

NCT01263769

COMPLETED Phase 1 29 participants

Neoadjuvant MEDI 4736 +/- Tremelimumab in Locally Advanced Renal Cell Carcinoma

Moshe Ornstein

NCT02762006

COMPLETED Phase 2 29 participants

SBRT (Stereotactic Body Radiation Therapy) in Combination With Nivolumab/Ipilimumab in Renal Cell Carcinoma (RCC) / Kidney Cancer Patients

University of Texas Southwestern Medical Center

NCT03065179

COMPLETED Phase 2 27 participants

Interleukin-2 and Pembrolizumab for Metastatic Kidney Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT02964078

COMPLETED Phase 2 26 participants

Bevacizumab and Aldesleukin in Treating Patients With Metastatic Clear Cell Carcinoma of the Kidney

Jorge A. Garcia, MD

NCT00853021

COMPLETED Phase 2 26 participants

Tretinoin Plus Interferon Alfa in Treating Patients With Metastatic Kidney Cancer

Weill Medical College of Cornell University

NCT00003656

COMPLETED Phase 2 23 participants

Everolimus and Imatinib Mesylate in Treating Patients With Metastatic or Unresectable Kidney Cancer

OHSU Knight Cancer Institute

NCT00331409

COMPLETED Phase 2 22 participants

Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT00024258

COMPLETED NA 22 participants

Serial Ultrasound in Metastatic Renal Cell Carcinoma (mRCC)

Stanford University

NCT04508725

COMPLETED Phase 2 18 participants

DC Vaccine Combined With IL-2 and IFNα-2a in Treating Patients With mRCC

Dartmouth-Hitchcock Medical Center

NCT00085436

COMPLETED Phase 1 15 participants

Vaccine Therapy in Treating Patients With Stage III or Stage IV Kidney Cancer

Duke University

NCT00005816

COMPLETED Early Phase 1 15 participants

Genistein and Interleukin-2 in Treating Patients With Metastatic Melanoma or Kidney Cancer

Northwestern University

NCT00276835

COMPLETED Phase 2 9 participants

Gemcitabine and Irinotecan in Treating Patients With Metastatic Kidney Cancer

The Cleveland Clinic

NCT00401128

COMPLETED Phase 2 7 participants

Interferon Alfa (IFN-Alpha-1b) in Renal Cancer With Metastatic Kidney Cancer

Case Comprehensive Cancer Center

NCT00278174

COMPLETED Phase 2

Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma

Eastern Cooperative Oncology Group

NCT00003308

COMPLETED Phase 4

Interleukin-2 in Treating Patients With Metastatic Kidney Cancer

Case Comprehensive Cancer Center

NCT00006864

COMPLETED Phase 2

Carboxyamidotriazole in Treating Patients With Advanced Kidney Cancer

Eastern Cooperative Oncology Group

NCT00005045

COMPLETED NA

Fludarabine, Cyclophosphamide, and Alemtuzumab in Treating Patients With Recurrent or Metastatic Renal Cell Carcinoma (Kidney Cancer) Undergoing Allogeneic Stem Cell Transplantation

Baylor College of Medicine

NCT00073879

COMPLETED Phase 1

Biological Therapy in Treating Patients With Metastatic Melanoma or Metastatic Kidney Cancer

National Cancer Institute (NCI)

NCT00020540

COMPLETED Phase 2

Flavopiridol in Treating Patients With Unresectable or Metastatic Kidney Cancer

SWOG Cancer Research Network

NCT00016939

COMPLETED Phase 1

Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors

Indiana University School of Medicine

NCT00003107

COMPLETED Phase 2

SU5416 and Interferon Alfa-2b in Treating Patients With Unresectable or Metastatic Kidney Cancer

City of Hope Medical Center

NCT00006384

Reading the Kidney Cancer Trial Landscape

ClinicalTrials.gov lists 69 US studies indexed under Kidney Cancer, and 19 of those are currently open to recruitment — roughly 28% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Kidney Cancer shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 42 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Kidney Cancer is led by National Cancer Institute (NCI) with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 69 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Kidney Cancer?

PlainTrial tracks 69 US clinical trials for Kidney Cancer, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Kidney Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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