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NCT07001930 · ClinicalTrials.gov registry record · Phase 1
Effects of Cannabidiol on Stress and Nicotine Withdrawal
A Phase 1 study of Stress and Nicotine Dependence, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 90
- Enrollment target
- 1
- Study location
NCT07001930: Recruiting Phase 1 study of Stress and Nicotine Dependence, sponsored by Johns Hopkins University.
NCT07001930 is a Phase 1 study of Stress and Nicotine Dependence that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 90 participants, below the 786-participant average among 152 other Stress trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07001930, a Phase 1 study of Stress and Nicotine Dependence, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 90 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users. The main objectives of the study include examining the effect CBD has on stress, tobacco dependence, tobacco withdrawal, and sex differences between these types of stress. Participants will be administered CBD and exposed to stress. Biological and subjective measures will be collected. Participants may be asked to stop use for 24 hours. Researchers will also investigate withdrawal effects between participants who have not smoked nicotine in 24 hours and those who have continued to smoke before each session.
Primary Outcome
Negative affect is measured using the Subjective State Scale which includes 4 items measuring negative affect. The scale has a range of 0 to 28 with higher scores indicating greater negative affect.
Conditions Studied
Interventions
- DRUG Epidiolex
Study Locations (1)
Maryland
- Behavioral Pharmacology Research Unit - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2025-08-25 |
| Est. Completion | 2029-09-01 |
| Phase | Phase 1 |
What NCT07001930 shows while recruiting
NCT07001930 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 90 participants, a relatively small participant target, below the 786-participant average among 152 other Stress trials with a reported enrollment target (89% lower).
The record links to 4 conditions, with Stress appearing as the primary indexed condition, and to 1 intervention - of which Epidiolex is the first listed.
NCT07001930 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT07001930 about?
NCT07001930 is a clinical study titled "Effects of Cannabidiol on Stress and Nicotine Withdrawal". The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users. The main objectives of the study include examining the effect CBD has on stress, tobacco dependence, tobacco withdrawal, and sex differences between t...
What is the current status of trial NCT07001930?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 90 participants. The study started on 2025-08-25. Estimated completion is 2029-09-01.
What conditions does trial NCT07001930 study?
This clinical trial studies the following conditions: Stress, Nicotine Dependence, Tobacco Smoking, CBD.
What interventions are being tested in trial NCT07001930?
The interventions under investigation include: Epidiolex (DRUG).
Who is sponsoring clinical trial NCT07001930?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07001930 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Stress
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07001930's enrollment target sits among peer trials
90 71st of 152 higher than 81 of 152 other Stress trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stress trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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