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NCT01034020 · ClinicalTrials.gov registry record · Phase 1
Effects of Nicotine on Elements of Attentions in Smokers and Nonsmokers
A Phase 1 study of Nicotine Dependence and Substance Related Disorder, sponsored by National Institute on Drug Abuse (NIDA).
- Completed
- Registry status
- Phase 1
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT01034020: Completed Phase 1 study of Nicotine Dependence and Substance Related Disorder, sponsored by National Institute on Drug Abuse (NIDA).
NCT01034020 is a Phase 1 study of Nicotine Dependence and Substance Related Disorder that has completed, run by National Institute on Drug Abuse (NIDA). The registered enrollment target is 100 participants, below the 185-participant average among 67 other Nicotine Dependence trials with a reported enrollment target (46% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01034020, a Phase 1 study of Nicotine Dependence and Substance Related Disorder, has completed, sponsored by National Institute on Drug Abuse (NIDA).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: \- Many cigarette smokers claim that smoking helps them stay alert and improves their concentration, and have reported problems in attention and concentration after quitting smoking. Some research has indicated that nicotine can enhance certain aspects of attention and memory in humans. However, more research is needed to determine how nicotine affects different elements of the brain's ability to pay attention. Knowing which aspects of attention are affected by nicotine may help produce new medications and therapies to help people successfully stop smoking. Objectives: * To investigate the dose-related effects of nicotine on the ability to pay attention in smokers and nonsmokers. * To compare the effects of nicotine in smokers and nonsmokers. Eligibility: \- Individuals between 18 and 50 years of age who are either current smokers (at least 15 cigarettes per day on average for at least 2 years) or healthy, nonsmoking volunteers. Design: * The study will consist of one training session and three testing sessions. Each session will last about 2 hours. * The training session will introduce participants to the study tests and evaluate their tolerance of the two levels of nicotine nasal spray used in the study. Smokers will receive the higher dose of nicotine to introduce them to the effects of the spray. Nonsmokers will be given first the lower dose of the spray, followed by higher dose at least 30 minutes later. Nonsmoking participants who cannot tolerate the higher dose will not continue in the study. * At the start of each testing session, smokers will have one cigarette to standardize the time of the most recent exposure to nicotine. * During the testing sessions, participants will receive a placebo spray, a lower dose of nicotine, or a higher dose of nicotine, and then will be asked to perform tests that evaluate mood, attention, and performance.
Conditions Studied
Interventions
- DRUG Nicotine
Study Locations (1)
Maryland
- National Institute on Drug Abuse, Biomedical Research Center (BRC) - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2006-02-14 |
| Est. Completion | 2009-11-03 |
| Phase | Phase 1 |
What the finished NCT01034020 record still lists
NCT01034020 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 185-participant average among 67 other Nicotine Dependence trials with a reported enrollment target (46% lower).
The record links to 2 conditions, with Nicotine Dependence appearing as the primary indexed condition, and to 1 intervention - of which Nicotine is the first listed.
NCT01034020 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT01034020 about?
NCT01034020 is a clinical study titled "Effects of Nicotine on Elements of Attentions in Smokers and Nonsmokers". Background: \- Many cigarette smokers claim that smoking helps them stay alert and improves their concentration, and have reported problems in attention and concentration after quitting smoking. Some research has indicated that nicotine can enhance certain aspects of attention and memory in humans....
What is the current status of trial NCT01034020?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 100 participants. The study started on 2006-02-14. Estimated completion is 2009-11-03.
What conditions does trial NCT01034020 study?
This clinical trial studies the following conditions: Nicotine Dependence, Substance Related Disorder.
What interventions are being tested in trial NCT01034020?
The interventions under investigation include: Nicotine (DRUG).
Who is sponsoring clinical trial NCT01034020?
This trial is sponsored by National Institute on Drug Abuse (NIDA), which has 335 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01034020 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Nicotine Dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01034020's enrollment target sits among peer trials
100 35th of 67 higher than 33 of 67 other Nicotine Dependence trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Nicotine Dependence trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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