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NCT06688539 · ClinicalTrials.gov registry record · Phase 4
E-cigarette Cessation in Adults Who Co-use Cannabis
A Phase 4 study of Tobacco Use Disorder and Nicotine Dependence, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 105
- Enrollment target
- 3
- Study locations
NCT06688539: Recruiting Phase 4 study of Tobacco Use Disorder and Nicotine Dependence, sponsored by Medical University of South Carolina.
NCT06688539 is a Phase 4 study of Tobacco Use Disorder and Nicotine Dependence that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 105 participants, below the 238-participant average among 70 other Tobacco Use Disorder trials with a reported enrollment target (56% lower). The trial reports 3 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06688539, a Phase 4 study of Tobacco Use Disorder and Nicotine Dependence, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 105 participants
- Enrollment target
- 3
- Study locations
Study Summary
The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis. Varenicline is not FDA approved for e-cigarette cessation, but is FDA approved for cigarette cessation. Investigators are also interested in how cannabis/marijuana and tobacco interact during a tobacco quit attempt. All participants will receive e-cigarette cessation treatment for 12 weeks. To qualify, participants must be between the ages of 18-40 and use both e-cigarettes and cannabis. Participants do not need to be interested in quitting cannabis to qualify. This study is being conducted at three sites: the Medical University of South Carolina in Charleston, SC, Behavioral Health Services in Pickens, SC, and MUSC Lancaster in Lancaster, SC.
Primary Outcome
7-day point prevalence abstinence from e-cigarettes at the end of treatment (Week 12) will be assessed via biochemical verification (urinary cotinine; ng/ml) and will be compared to cigarette abstinence rates from the parent study (as historical controls)
Conditions Studied
Interventions
- BEHAVIORAL Counseling
- DRUG Varenicline Pill
- BEHAVIORAL Contingency management
Study Locations (3)
South Carolina
- MUSC Charleston - Charleston
- MUSC Lancaster - Lancaster
- Behavioral Health Services of Pickens County - Pickens
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2025-02-19 |
| Est. Completion | 2026-09-01 |
| Phase | Phase 4 |
What NCT06688539 shows while recruiting
NCT06688539 is an interventional study that assigns participants to a tested intervention. The registered 105 participants enrollment target is mid-sized for trials with a published cap, below the 238-participant average among 70 other Tobacco Use Disorder trials with a reported enrollment target (56% lower).
The record links to 2 conditions, with Tobacco Use Disorder appearing as the primary indexed condition, and to 3 interventions - of which Counseling is the first listed.
NCT06688539 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT06688539 about?
NCT06688539 is a clinical study titled "E-cigarette Cessation in Adults Who Co-use Cannabis". The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis. Varenicline is not FDA approved for e-cigarette cessation, but is FDA approved for cigarette cessation. Inve...
What is the current status of trial NCT06688539?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 105 participants. The study started on 2025-02-19. Estimated completion is 2026-09-01.
What conditions does trial NCT06688539 study?
This clinical trial studies the following conditions: Tobacco Use Disorder, Nicotine Dependence.
What interventions are being tested in trial NCT06688539?
The interventions under investigation include: Counseling (BEHAVIORAL), Varenicline Pill (DRUG), Contingency management (BEHAVIORAL).
Who is sponsoring clinical trial NCT06688539?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06688539 being conducted?
This trial has 3 study locations across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Tobacco Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06688539's enrollment target sits among peer trials
105 37th of 70 higher than 34 of 70 other Tobacco Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Tobacco Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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