Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Nicotine Dependence: early-phase trial registry
19 of 69 indexed Nicotine Dependence trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #201 of 28,707 conditions by registered trial count.
69 US clinical trials · 19 currently recruiting · #201 of 28,707 conditions by registered trial count
Nicotine Dependence: 69 US clinical trials tracked, 19 recruiting.
Nicotine Dependence is the subject of 69 registered US clinical trials on ClinicalTrials.gov, 19 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 9 of these trials.
Enrollment posture brief
Registry condition nicotine-dependence
OPEN 19 | RECR 28% | LATE 13 | EARLY 22 | RANK #201 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Hypoxia (28% recruiting · 40 trials)
Nicotine Dependence lists 19 open slots (28% of 69 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Nicotine Dependence on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Nicotine Dependence is recruiting below its size-band peers.
19 of 69 indexed trials (27.5%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Nicotine Dependence trials is spread across many organizations.
Yale University accounts for 9 of 69 trials (13%). 34 distinct sponsors appear on at least one study for this condition label.
-
Typical Nicotine Dependence enrolment sits around 104 participants.
Median target enrolment is 104 among the 68 trials that report a genuine target (sentinel values excluded). 33 of those (48.5%) plan for fewer than 100 participants.
-
Nicotine Dependence research is mostly interventional.
64 interventional and 5 observational studies make up this index (92.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
69 total, page 2 of 2
Varenicline for the Treatment of Smokeless Tobacco
Mayo Clinic
NCT00813917
Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers
Jed E. Rose
NCT01926626
Motivational Interviewing Compared to Psychoeducation for Smoking Precontemplators With SMI
Massachusetts General Hospital
NCT01982617
AXS-05 Phase II Trial on Smoking Behavior
James Davis
NCT03471767
Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia
University of Maryland, Baltimore
NCT00770237
Treatment for Nicotine Addiction in Women
Yale University
NCT02448654
New Approaches to Smoking Cessation in Heavy Drinkers
Yale University
NCT02151591
The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence
Duke University
NCT02590393
Transcranial Magnetic Stimulation Effects on Nicotine Craving
Medical University of South Carolina
NCT01690130
Assessment of Craving in Nicotine-Dependent Patients With Schizophrenia Using Virtual Reality
National Institute on Drug Abuse (NIDA)
NCT01031433
Short-Term Cardiovascular Effects of E-Cigarettes: Influence of Device Power
University of California, San Francisco
NCT03839745
Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels
Mclean Hospital
NCT01588561
Nicotine Vaccination and Nicotinic Receptor Occupancy
Yale University
NCT00996034
Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH
University of California, San Francisco
NCT04449510
PET Imaging of Nicotinic Acetylcholine Receptors
National Institute on Drug Abuse (NIDA)
NCT01046513
Nicotine Differences in Smokers
Yale University
NCT05159934
Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm
Yale University
NCT01699607
Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder
Medical University of South Carolina
NCT05796791
Bupropion Treatment for Youth Smoking Cessation
University of Arizona
NCT00344695
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 10 |
| Phase 2 | 12 |
| Phase 3 | 4 |
| Phase 4 | 9 |
Top Sponsors
Named interventions
Most-linked intervention names on Nicotine Dependence records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Nicotine Dependence trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Nicotine Dependence page
69 registered trials, 19 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 19 Nicotine Dependence trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Yale University sponsors the most Nicotine Dependence trials on record, review their full trial history before evaluating a specific study. See Yale University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Nicotine Dependence condition card totals 69 registered trials; most-linked intervention Nicotine Patch; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.