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NCT06678789 · ClinicalTrials.gov registry record · NA
Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
A NA study of Smoking Cessation and Nicotine Dependence, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06678789: Recruiting NA study of Smoking Cessation and Nicotine Dependence, sponsored by Medical University of South Carolina.
NCT06678789 is a NA study of Smoking Cessation and Nicotine Dependence that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 50 participants, below the 474-participant average among 188 other Smoking Cessation trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06678789, a NA study of Smoking Cessation and Nicotine Dependence, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
Tobacco-free oral nicotine pouches (such as Zyn brand) are a less harmful alternative to cigarette smoking. Pouches, however, contain nicotine, and addictive substance that is not risk-free. The present study is evaluating how well nicotine pouches, at different nicotine levels, help people switch away from smoking cigarettes. People who smoke cigarettes will be asked to answer questions about their tobacco product use and provide breath samples and cheek swab samples at an in-person visit to MUSC Charleston. Participants will then be provided with a 28-day supply of nicotine pouches, and will be asked to switch from smoking to pouches over the course of 4 weeks. Finally, participants will complete a final visit at MUSC, and will answer more questions about their tobacco use 1-month later.
Primary Outcome
Switching will be defined at 7-day point-prevalence biochemically-confirmed abstinence from cigarettes alongside self-reported use of nicotine pouches. Non-responders and missing data will be coded as smoking.
Conditions Studied
Interventions
- BEHAVIORAL High Nicotine Dose
- BEHAVIORAL Low Nicotine Dose
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-02-14 |
| Est. Completion | 2027-02-28 |
| Phase | NA |
What NCT06678789 shows while recruiting
NCT06678789 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 474-participant average among 188 other Smoking Cessation trials with a reported enrollment target (89% lower).
The record links to 3 conditions, with Smoking Cessation appearing as the primary indexed condition, and to 2 interventions - of which High Nicotine Dose is the first listed.
NCT06678789 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT06678789 about?
NCT06678789 is a clinical study titled "Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches". Tobacco-free oral nicotine pouches (such as Zyn brand) are a less harmful alternative to cigarette smoking. Pouches, however, contain nicotine, and addictive substance that is not risk-free. The present study is evaluating how well nicotine pouches, at different nicotine levels, help people switch a...
What is the current status of trial NCT06678789?
This trial is currently recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2025-02-14. Estimated completion is 2027-02-28.
What conditions does trial NCT06678789 study?
This clinical trial studies the following conditions: Smoking Cessation, Nicotine Dependence, Cigarette Smoking.
What interventions are being tested in trial NCT06678789?
The interventions under investigation include: High Nicotine Dose (BEHAVIORAL), Low Nicotine Dose (BEHAVIORAL).
Who is sponsoring clinical trial NCT06678789?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06678789 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Smoking Cessation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06678789's enrollment target sits among peer trials
50 145th of 188 higher than 38 of 188 other Smoking Cessation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Smoking Cessation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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