Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06998238 · ClinicalTrials.gov registry record · NA
Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia
A NA study of Insulin Resistance and Overweight and Obesity, sponsored by University of Missouri-Columbia.
- Active
- Registry status
- NA
- Development phase
- 8
- Enrollment target
- 1
- Study location
NCT06998238: Active NA study of Insulin Resistance and Overweight and Obesity, sponsored by University of Missouri-Columbia.
NCT06998238 is a NA study of Insulin Resistance and Overweight and Obesity that is active but no longer recruiting, run by University of Missouri-Columbia. The registered enrollment target is 8 participants, below the 245-participant average among 120 other Insulin Resistance trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06998238, a NA study of Insulin Resistance and Overweight and Obesity, is active but no longer recruiting, sponsored by University of Missouri-Columbia.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 8 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators will measure plasma concentrations of the hormones insulin and testosterone as well as measures of insulin sensitivity in women with overweight or obesity who have insulin resistance (IR). Women who meet these criteria that also have elevated total or free testosterone will be eligible to participate in the diet intervention. The dietary intervention is designed to produce a 5% reduction in starting body weight to test whether weight loss will acutely lower fasting insulin and testosterone concentrations.
Primary Outcome
Fasting insulin (µU/mL) will be measured and compared to baseline values. Samples are sent to an external CLIA-compliant lab (Quest Diagnostics) for analysis.
Conditions Studied
Interventions
- BEHAVIORAL Mediterranean-based, carbohydrate restricted, calorie reduced diet
Study Locations (1)
Missouri
- University of Missouri - Columbia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2024-01-07 |
| Est. Completion | 2026-04-01 |
| Phase | NA |
What the registry record for NCT06998238 still lists
NCT06998238 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 8 participants, a relatively small participant target, below the 245-participant average among 120 other Insulin Resistance trials with a reported enrollment target (97% lower).
The record links to 3 conditions, with Insulin Resistance appearing as the primary indexed condition, and to 1 intervention - of which Mediterranean-based, carbohydrate restricted, calorie reduced diet is the first listed.
NCT06998238 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT06998238 about?
NCT06998238 is a clinical study titled "Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia". The investigators will measure plasma concentrations of the hormones insulin and testosterone as well as measures of insulin sensitivity in women with overweight or obesity who have insulin resistance (IR). Women who meet these criteria that also have elevated total or free testosterone will be elig...
What is the current status of trial NCT06998238?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 8 participants. The study started on 2024-01-07. Estimated completion is 2026-04-01.
What conditions does trial NCT06998238 study?
This clinical trial studies the following conditions: Insulin Resistance, Overweight and Obesity, Hyperandrogenemia.
What interventions are being tested in trial NCT06998238?
The interventions under investigation include: Mediterranean-based, carbohydrate restricted, calorie reduced diet (BEHAVIORAL).
Who is sponsoring clinical trial NCT06998238?
This trial is sponsored by University of Missouri-Columbia, which has 291 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06998238 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Insulin Resistance
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06998238's enrollment target sits among peer trials
8 116th of 120 higher than 3 of 120 other Insulin Resistance trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Insulin Resistance trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Metabolic Adaptations to Weight Loss With and Without Exercise
RECRUITING · NA
-
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
RECRUITING · NA
-
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
RECRUITING · NA
-
Small Extracellular Vesicles and Insulin Action
RECRUITING · NA
-
Exercise Effects on Adipose Tissue Structure and Function
RECRUITING · NA
-
New Mechanisms of Obesity
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI