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NCT05806801 · ClinicalTrials.gov registry record · NA
Metabolic Adaptations to Weight Loss With and Without Exercise
A NA study of Obesity and Insulin Resistance, sponsored by University of Michigan.
- Recruiting
- Registry status
- NA
- Development phase
- 68
- Enrollment target
- 1
- Study location
NCT05806801: Recruiting NA study of Obesity and Insulin Resistance, sponsored by University of Michigan.
NCT05806801 is a NA study of Obesity and Insulin Resistance that is actively recruiting participants, run by University of Michigan. The registered enrollment target is 68 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05806801, a NA study of Obesity and Insulin Resistance, is actively recruiting participants, sponsored by University of Michigan.
- RECRUITING
- Registry status
- NA
- Development phase
- 68 participants
- Enrollment target
- 1
- Study location
Study Summary
Study Purpose: The combination of caloric restriction and exercise is the most common first-line treatment for obesity-related disorders, yet we know very little about how these two very different treatments work together. A deeper understanding about mechanisms underlying the health benefits of adding exercise to a weight loss program will not only aid efforts to optimize more effective lifestyle interventions, but it can also uncover novel targets for the treatment/prevention of obesity-related diseases. Although a reduction in body fat is the fundamental adaptation to weight loss, we know almost nothing about the effects that adding exercise has on structural and functional changes within fat tissue that may further enhance metabolic health. This is very important because many obesity-related metabolic health complications are tightly linked with abnormalities in abdominal fat tissue. We argue exercise-induced modifications in abdominal fat tissue will reveal persistent health benefits even if some weight is regained Study Summary: 10% Weight Loss Phase - Subject participation in the study will involve a series of metabolic tests before, at midpoint, and after undergoing a 10% weight loss program (with or without exercise training depending on group randomization). During this, subjects will be randomized into one of two different experimental groups: 1. Moderate Intensity Continuous Training (MICT) exercise group 2. No exercise (control) group Follow-up Phase: After completing the metabolic testing post-weight loss, all study-related diet and exercise supervision will end and subjects will be free to make their own choices regarding diet and exercise/physical activity behavior. Subjects will then be asked to complete follow-up testing at 2-, 4- and 6- months post-weight loss. Total involvement in the study for each subject will likely be about 10-13 months (4-7 months during weight loss phase, 6 months during follow-up phase).
Primary Outcome
a hyperinsulinemic-euglycemic clamp will be used to quantify peripheral insulin sensitivity
Conditions Studied
Interventions
- BEHAVIORAL MICT Exercise
- BEHAVIORAL No Exercise (Control)
Study Locations (1)
Michigan
- University of Michigan - Ann Arbor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 68 participants |
| Start Date | 2023-07-19 |
| Est. Completion | 2028-05-31 |
| Phase | NA |
What NCT05806801 shows while recruiting
NCT05806801 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 68 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (92% lower).
The record links to 6 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions - of which MICT Exercise is the first listed.
NCT05806801 reports a single indexed study location in Michigan.
Frequently Asked Questions
What is clinical trial NCT05806801 about?
NCT05806801 is a clinical study titled "Metabolic Adaptations to Weight Loss With and Without Exercise". Study Purpose: The combination of caloric restriction and exercise is the most common first-line treatment for obesity-related disorders, yet we know very little about how these two very different treatments work together. A deeper understanding about mechanisms underlying the health benefits of ad...
What is the current status of trial NCT05806801?
This trial is currently recruiting. It is a NA study. The enrollment target is 68 participants. The study started on 2023-07-19. Estimated completion is 2028-05-31.
What conditions does trial NCT05806801 study?
This clinical trial studies the following conditions: Obesity, Insulin Resistance, Weight Loss, Metabolic Syndrome, Metabolic Disease.
What interventions are being tested in trial NCT05806801?
The interventions under investigation include: MICT Exercise (BEHAVIORAL), No Exercise (Control) (BEHAVIORAL).
Who is sponsoring clinical trial NCT05806801?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05806801 being conducted?
This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obesity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05806801's enrollment target sits among peer trials
68 611th of 1053 higher than 439 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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