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Low Back Pain clinical trials
Every US clinical trial registered for Low Back Pain — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
123 US clinical trials · 31 currently recruiting
The research picture
Low Back Pain has 123 registered US clinical trials, 31 of them open to new participants right now — about 25% of the total.
- 31
- recruiting participants now
- 25%
- of trials open to enrollment
- 20
- in Phase 3–4 (later-stage)
- 8
- top sponsor: University of Utah
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Stratified Targeted Engagement From Primary Care to Physical Therapy (STEPPT)
San Diego State University
NCT07290361
The Spine Phenome Project
Ohio State University
NCT05776771
Evaluation of the Effects of a Rehabilitation Program in Individuals with Spine Pain
SpineZone Medical Fitness
NCT04081896
Nonpharmacologic Pain Management in FQHC Primary Care Clinics
University of Utah
NCT04923334
Overlapping Pain Trajectory Study
Children's Hospital Medical Center, Cincinnati
NCT05752396
Wearable Spine Health System for Military Readiness
Ohio State University
NCT05944354
Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P)
Evon Medics
NCT06671132
Time to BBVNA Relief
Yale University
NCT07433634
Physical Exam, Static & Dynamic Ultrasound Assessment, & Treatment of Thoracolumbar Fascia (TLF) Mediated Low Back Pain
Edward Via Virginia College of Osteopathic Medicine
NCT06818175
Trigger Point Injection for Myofascial Pain Syndrome in the Low Back: A Randomized Controlled Trial
Madigan Army Medical Center
NCT04704297
Biomechanical Validation of the CATT
VA Office of Research and Development
NCT06013878
Neural Mechanisms of Meditation for Opioid-Treated Chronic Low Back Pain
University of Utah
NCT05607381
A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy
Northwestern University
NCT07224945
Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.
Montefiore Medical Center
NCT05721027
Blood Flow Restriction Training as a Targeted Intervention for Rowers With Back Pain.
Loma Linda University
NCT07130812
Conventional vs Bipolar SIJ RFA for Treatment of Sacroiliac Joint Pain
University of Utah
NCT05409443
Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Lumbar Pain
R3 Stem Cell
NCT06361485
Perspectives on Spinal Manipulative Therapy for Low Back Pain
University of Florida
NCT06590116
Therapeutic Mechanisms of Epidural Spinal Cord Stimulation
University of Alabama at Birmingham
NCT05556902
Dronabinol as an Adjunct for Reducing Pain
Christopher D. Verri
NCT06454669
Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control
Boston Scientific Corporation
NCT07190807
Erector Spinae Plane Block for Acute Back Pain in the Emergency Department
Rush University Medical Center
NCT06745453
Feasibility of Identifying Brain Mechanisms of Qigong and Behavioral Outcomes After Qigong Practice in People With Chronic Low Back Pain
University of Minnesota
NCT04164225
AuriculoTherapy NeuroImaging
Keith M Vogt
NCT06825390
Is Conditioned Pain Modulation Predictive of Clinical Improvement in Patients With Chronic Low Back Pain?
Brooke Army Medical Center
NCT06544525
Treatment for Sacroiliac Joint Pain Using Platelet-rich Plasma (PRP) Versus Steroid/Anesthetic
University of Utah
NCT05121961
Chronic Low Back Pain and Osteopathic Manipulation Treatment
Edward Hines Jr. VA Hospital
NCT07161661
Non-surgical Spinal Decompression Therapy and Outcomes
University of South Florida
NCT06525896
Effect of Lumbar Manipulation on Intervertebral Motion, Pain, and Disability
Ithaca College
NCT06294132
Endogenous Opioid Response to Injections
Middle Tennessee Research Institute
NCT06666621
Ischemic Preconditioning in Osteoarthritis and Back Pain
University of Illinois at Chicago
NCT07003113
Resolving the Burden of Low Back Pain in Military Service Members and Veterans: A Pragmatic Clinical Trial
Sara Gorczynski
NCT04494490
SMART Stepped Care Management for Low Back Pain in the Military Health System
Brooke Army Medical Center
NCT04172038
Self-Administered Acupressure for Veterans With Chronic Back Pain
VA Office of Research and Development
NCT05423145
Non-pharmacological Treatment for Pain After Spine Surgery
Dan Rhon
NCT04770480
The RESET Clinical Trial: SPRINT® Peripheral Nerve Stimulation for the Treatment of Back Pain
SPR Therapeutics
NCT04246281
Development of STEPPT
San Diego State University
NCT06835439
Intracept Intraosseous Basivertebral Nerve Ablation
University of Utah
NCT05660512
LLLT to Reduce Low Back Pain
Mayo Clinic
NCT06007976
Two Point Discrimination
Children's Hospital Medical Center, Cincinnati
NCT03686748
Improving Core Strength in the Warfighter With a Novel Device
David Moss
NCT06797830
Health Coaching for Back Pain After Emergency Department Discharge
Vanderbilt University Medical Center
NCT06400602
TeleYoga for Chronic Low Back Pain: A Quantitative and Qualitative Study
Taylor Rees
NCT07216417
VIA Disc NP Pilot for Patients With Symptomatic Degenerated Discs
VIVEX Biologics
NCT05201287
VIA Disc Nucleus Pulposus Older Patients Pilot
VIVEX Biologics
NCT05412277
Analysis of Crepitus in Human Subjects
National University of Health Sciences
NCT05425017
Prevention of Low Back Pain in the Military
University of Florida
NCT00373009
Targeted Interventions to Prevent Chronic Low Back Pain in High Risk Patients
University of Pittsburgh
NCT02647658
Efficacy and Safety of Oxycodone/Naloxone Controlled-release Tablets (OXN) Compared to Placebo in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain
Purdue Pharma
NCT01358526
Efficacy Study to Evaluate Buprenorphine HCl Buccal Film in Opioid-Experienced Subjects
BioDelivery Sciences International
NCT01675167
Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets for Moderate to Severe Chronic Low Back Pain
Teva Branded Pharmaceutical Products R&D
NCT01789970
Low Back Pain Patient Education Evaluation
Stanford University
NCT00000408
Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain
Purdue Pharma
NCT01427270
Osteopathic Health Outcomes in Chronic Low Back Pain (OSTEOPATHIC) Trial
University of North Texas Health Science Center
NCT00315120
A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain
Purdue Pharma
NCT01427283
Osteopathic Manipulative Medicine in Pregnancy: Physiologic and Clinical Effects
University of North Texas Health Science Center
NCT00426244
Study of COV795 in Subjects With Osteoarthritis or Chronic Low Back Pain
Mallinckrodt
NCT01451385
Predictive Factors for LBP Interventional Treatment Outcomes
Johns Hopkins University
NCT02329951
Comparison of CAM and Conventional Mind-Body Therapies for Chronic Back Pain
Kaiser Permanente
NCT01467843
PNE Effectiveness Cluster Trial
University of Utah
NCT03168165
Aging Successfully With Pain
University of Pittsburgh
NCT01405716
Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain
Pain Management Center of Paducah
NCT00370799
Effect of Spinal Manipulation on Sensorimotor Functions in Back Pain Patients
Palmer College of Chiropractic
NCT00830596
Acute Low Back Pain. Topical Diclofenac and Oral Ibuprofen.
Montefiore Medical Center
NCT04611529
A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain.
Montefiore Medical Center
NCT03861611
Rest Before Physical Therapy in Adolescents With Active Spondylolysis and Spondylolisthesis
Nationwide Children's Hospital
NCT02332200
Power Over Pain (POP) Study
University of Washington
NCT01800604
Electrical Stimulation for the Treatment of Back Pain Using Peripheral Nerve Stimulation (PNS)
SPR Therapeutics
NCT03179202
The Effect of AposTherapy on Pain and Function in a Non Specific Low Back Pain
Montefiore Medical Center
NCT03167671
The RELIEF Study - Researching the Effectiveness of Lumbar Interventions for Enhancing Function
Ohio University
NCT01854892
A Randomized Controlled Trial of Best Approach to Care Compared to Diversified Chiropractic Adjustive Technique
Parker College of Chiropractic
NCT00163124
Telehealth Physical Therapy for Chronic Back Pain - Ancillary Study to NCT03859713
University of Utah
NCT05103462
Effectiveness of Lumbar Facet Joint Nerve Blocks
Pain Management Center of Paducah
NCT00355914
Study of Opioid Use After Lumbar and Cervical Spine Surgery
Brooke Army Medical Center
NCT02674711
Low-Cost Tool for Compliance and Treatment-Tracking of Low Back Pain Patients
Mayo Clinic
NCT03478007
The Mechanisms of Manual Therapy in the Treatment of Low Back Pain
University of Florida
NCT01168999
Effectiveness of Adding Behavioral Therapy to Physical Therapy to Treat Low Back Pain
University of Florida
NCT00373867
Mechanisms of Specific Trunk Exercises in Low Back Pain
University of Vermont
NCT01362049
A Follow-up Comparison of Active Versus Passive Manual Therapy in Patients With Low Back Pain
St. Ambrose University
NCT03758807
The Use of Methylsulfonylmethane (MSM) in the Treatment of Low Back Pain
Mike O'Callaghan Military Hospital
NCT02268305
High Level Pulsed Heat Versus Low Level Steady Heat in Subjects With Chronic Low Back Pain
Soovu Labs
NCT04109703
Evaluation of Efficacy and Comfort: A Trial on the Incrediwear Back Brace in Patients With Chronic Lower Back Pain
Johns Hopkins University
NCT06126887
Comparison of Extensible and Inextensible Lumbosacral Orthoses for Lower Back Pain
Medical University of South Carolina
NCT01933399
Soft Active Back Exosuit to Reduce Workplace Back Pain
Wyss Institute at Harvard University
NCT05802914
Using Structural Health Monitoring to Improve Diagnosis and Treatment of Low Back Injury in U.S. Service Members- Phase 2
Baylor University
NCT02352532
Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain
Evon Medics
NCT06218407
Brain Mechanisms of Acupuncture Treatment in Chronic Low Back Pain
Brigham and Women's Hospital
NCT01595451
Effect of Nitrous Oxide in Treating Neuropathic Pain: A Study in Chronic Low Back Pain Patients
The Cleveland Clinic
NCT01172600
Patient Education for Patients With Back Pain Referred to Physical Therapy
University of Utah
NCT02648373
Magnets in the Treatment of Sciatica
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00044109
Resistance Exercise Effects on Fear Avoidance and Physical Function in Obese Older Adults With Low Back Pain
University of Florida
NCT01250262
Recurrent Low Back Pain:Linking Mechanisms to Outcomes
Drexel University
NCT01085604
Effect of Music and Other Audio Recordings for Chronic Pain in Aging Adults
Baylor University
NCT04785963
Pregnancy-Related Low Back Pain and Complementary and Alternative Medicine (CAM) Treatment
Oregon Health and Science University
NCT00937365
Study of Low Level Laser Therapy to Treat Low Back Pain
Erchonia Corporation
NCT01835756
Interventional Study of Effects on Spine Height With Two Unloading Positions
Texas Tech University Health Sciences Center
NCT01048749
Acupuncture Analgesia in Relation to Psychiatric Comorbidity
Brigham and Women's Hospital
NCT00307788
Core Strengthening for DRA in Postpartum Women
Hospital for Special Surgery, New York
NCT03595696
True Functional Restoration and Analgesia in Non-Radicular Low Back Pain
Shirley Ryan AbilityLab
NCT01455519
Battlefield Acupuncture for Low Back Pain
The Geneva Foundation
NCT03491124
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 5 |
| Phase 3 | 12 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Low Back Pain Trial Landscape
ClinicalTrials.gov lists 123 US studies indexed under Low Back Pain, and 31 of those are currently open to recruitment — roughly 25% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Low Back Pain shows 20 late-stage studies (Phase 3 and Phase 4 combined) alongside 12 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Low Back Pain is led by University of Utah with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Low Back Pain?
PlainTrial tracks 123 US clinical trials for Low Back Pain, of which 31 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Low Back Pain?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.