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NCT03318094 · ClinicalTrials.gov registry record · Phase 1
Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity
A Phase 1 study of Healthy and Obesity, sponsored by Vanderbilt University Medical Center.
- Active
- Registry status
- Phase 1
- Development phase
- 36
- Enrollment target
- 1
- Study location
NCT03318094: Active Phase 1 study of Healthy and Obesity, sponsored by Vanderbilt University Medical Center.
NCT03318094 is a Phase 1 study of Healthy and Obesity that is active but no longer recruiting, run by Vanderbilt University Medical Center. The registered enrollment target is 36 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03318094, a Phase 1 study of Healthy and Obesity, is active but no longer recruiting, sponsored by Vanderbilt University Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 36 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to better understand the contribution of sympathetic vasoconstriction to impaired insulin-mediated vasodilation and subsequently insulin-mediated glucose uptake. The investigators will test the hypothesis that removal of sympathetic vasoconstriction can result in improvement in insulin-mediated vasodilation and subsequently sensitivity to insulin-mediated glucose uptake.
Primary Outcome
The Primary Outcome will be the change in CEU induced by insulin during hyperinsulinemic clamp compared to baseline. To test the null hypothesis that insulin will not produce any changes in microvascular blood volume using CEU in response to α-adrenergic blockade (phentolamine) in the isolated forearm model.
Conditions Studied
Interventions
- OTHER Saline
- DRUG Sodium Nitroprusside
- DRUG Phentolamine
Study Locations (1)
Tennessee
- Autonomic Dysfunction Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2017-10-24 |
| Est. Completion | 2027-11-30 |
| Phase | Phase 1 |
What the registry record for NCT03318094 still lists
NCT03318094 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 36 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (94% lower).
The record links to 3 conditions, with Healthy appearing as the primary indexed condition, and to 3 interventions - of which Saline is the first listed.
NCT03318094 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT03318094 about?
NCT03318094 is a clinical study titled "Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity". The purpose of this study is to better understand the contribution of sympathetic vasoconstriction to impaired insulin-mediated vasodilation and subsequently insulin-mediated glucose uptake. The investigators will test the hypothesis that removal of sympathetic vasoconstriction can result in improve...
What is the current status of trial NCT03318094?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 36 participants. The study started on 2017-10-24. Estimated completion is 2027-11-30.
What conditions does trial NCT03318094 study?
This clinical trial studies the following conditions: Healthy, Obesity, Insulin Resistance.
What interventions are being tested in trial NCT03318094?
The interventions under investigation include: Saline (OTHER), Sodium Nitroprusside (DRUG), Phentolamine (DRUG).
Who is sponsoring clinical trial NCT03318094?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03318094 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03318094's enrollment target sits among peer trials
36 595th of 1090 higher than 469 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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