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ClinicalTrials.gov 45 recruiting now official registry

Advanced Cancer clinical trials

45 of 123 indexed Advanced Cancer trials are currently recruiting.

123 US clinical trials · 45 currently recruiting

Advanced Cancer is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 45 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 85 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 19 of these trials.

The research picture

Advanced Cancer has 123 registered US clinical trials, 45 of them open to new participants right now, about 37% of the total.

45
recruiting participants now
37%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
19
top sponsor: M.D. Anderson Cancer Center
Phase 171Phase 214Phase 32

Active & Recent Trials

123 total, page 1 of 3

RECRUITING 10,600 participants

Evaluating Disparities in Precision Oncology

Indiana University

NCT06081517

RECRUITING NA 1,300 participants

Evaluating Personalized Therapeutics Clinic (PTC) on Drug-Drug Interactions and Drug-Gene Interactions

University of Chicago

NCT05166694

RECRUITING NA 1,000 participants

Longitudinal Screening for Financial Hardship to Improve Outcomes in Patients With Advanced Cancer

Alliance Foundation Trials

NCT06963723

RECRUITING NA 600 participants

BOLSTER: Learning New Skills to Thrive

Dana-Farber Cancer Institute

NCT06936878

RECRUITING 500 participants

AIMS Cancer Outcomes Study

Advanced Integrative Medical Science Institute

NCT04495790

RECRUITING Phase 2 497 participants

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

Apollomics

NCT03175224

RECRUITING 450 participants

Psychophysical Studies of Cancer Therapy Pain

M.D. Anderson Cancer Center

NCT00515060

RECRUITING Phase 1 442 participants

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

Artios Pharma

NCT04657068

RECRUITING Phase 1 332 participants

A Study in Patients With Advanced Cancers

BiOneCure Therapeutics

NCT05320588

RECRUITING Phase 1 332 participants

A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815

Jazz Pharmaceuticals

NCT05557045

RECRUITING Phase 1 330 participants

Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

I-Mab Biopharma US Limited

NCT04900818

RECRUITING 300 participants

Methods of Identifying Effective Off-Guideline Treatments for Advanced Cancer Patients (CC N-of-1)

Cancer Commons

NCT07343024

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING Phase 1 250 participants

A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs

Krystal Biotech

NCT06228326

RECRUITING Phase 1 234 participants

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK202 in Participants with Advanced Solid Tumors

Shanghai Allink Biotherapeutics Co.

NCT06707610

RECRUITING Phase 2 200 participants

Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)

Mirati Therapeutics

NCT05853575

RECRUITING Phase 2 200 participants

Psilocybin Therapy in Advanced Cancer

NYU Langone Health

NCT05398484

RECRUITING Phase 1 200 participants

First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer

OnKure

NCT06239467

RECRUITING Phase 2 180 participants

Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)

I-Mab Biopharma US Limited

NCT07432295

RECRUITING Phase 1 165 participants

A Study of PHN-012 in Patients With Advanced Solid Tumors

Pheon Therapeutics

NCT07127874

RECRUITING Phase 1 164 participants

Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors

Riboscience

NCT05270213

RECRUITING Phase 1 160 participants

Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

CJ Bioscience

NCT05877430

RECRUITING NA 155 participants

Development of an Educational Patient Decision Aid (Treatments in Advanced Cancer - Decision Aid, TA-DA) to Promote Shared Decision Making for Third-line or Beyond Palliative Systemic Therapy

M.D. Anderson Cancer Center

NCT07009886

RECRUITING 150 participants

Practical Geriatric Assessment (PGA) Implementation Strategies and Correlative Evaluations (PACE-70)

Abramson Cancer Center at Penn Medicine

NCT06870617

RECRUITING Phase 1 150 participants

Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

Incyclix Bio

NCT05735080

RECRUITING Phase 1 148 participants

A Study to Assess the Safety, Pharmacokinetics, and Antitumor Activity of BC3195 in Patients With Advanced or Metastatic Cancer

Biocity Biopharmaceutics Co.

NCT06548672

RECRUITING Phase 1 130 participants

Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors

Qurient Co.

NCT05394103

RECRUITING Phase 1 126 participants

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

7 Hills Pharma

NCT06362369

RECRUITING NA 120 participants

ALIGN for Older Adults With Cancer in SNFs

University of Colorado, Denver

NCT06616298

RECRUITING Phase 1 100 participants

Phase 1b/2 Study of Combination 177Lu Girentuximab Plus Cabozantinib and Nivolumab in Treatment naïve Patients With Advanced Clear Cell RCC

M.D. Anderson Cancer Center

NCT05663710

RECRUITING NA 90 participants

Electronic Patient Reporting of Symptoms and Unmet Needs to Connect Patients With Advanced Cancer to Palliative Care Services

Dartmouth-Hitchcock Medical Center

NCT07195513

RECRUITING Phase 1 80 participants

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

Angiex

NCT06440005

RECRUITING 80 participants

SPECT Imaging for Pharmacokinetics and dosimEtry Towards TREATment Optimization

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06389097

RECRUITING Phase 1 77 participants

A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer

Memorial Sloan Kettering Cancer Center

NCT05004116

RECRUITING NA 70 participants

Development and Pilot Trial of Focused ACT (FACT) for Patients With Advanced Cancer

M.D. Anderson Cancer Center

NCT07105033

RECRUITING NA 64 participants

Pilot Trial of Spiritual Care Interventions for Patients With Cancer

Weill Medical College of Cornell University

NCT06811376

RECRUITING NA 60 participants

A Chaplain-clinician Led Spiritual Care (PEACE) Intervention on Spiritual/Religious Beliefs Related to Medical Care in Patients With Advanced Cancer: a Pilot Clinical Trial

M.D. Anderson Cancer Center

NCT07246954

RECRUITING NA 60 participants

Integrating Pain-CBT Into an mHealth Analgesic Support Intervention for Patients With Chronic Pain From Advanced Cancers

Dana-Farber Cancer Institute

NCT06722014

RECRUITING Phase 3 50 participants

A Study to Provide Continued Access to and Assess Long-Term Safety of the Study Drug(s)

Daiichi Sankyo

NCT06174987

RECRUITING Phase 1 40 participants

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Memgen

NCT05076760

RECRUITING Phase 1 36 participants

Phase 1b Trial of BMS-986504 in Combination With Olaparib in Patients With MTAP Loss

M.D. Anderson Cancer Center

NCT07382544

RECRUITING Phase 2 30 participants

Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

M.D. Anderson Cancer Center

NCT06200155

RECRUITING Phase 1 26 participants

A First-in-human (FIH), Phase I Study of PTX-912 in Patients with Locally Advanced/Metastatic Solid Tumors

Proviva Therapeutics

NCT06190886

RECRUITING Phase 1 20 participants

Actinium 225 Labeled Anti-CEA Antibody (Ac225-DOTA-M5A) for the Treatment of CEA Producing Advanced or Metastatic Cancers

City of Hope Medical Center

NCT05204147

RECRUITING Phase 2 15 participants

Psilocybin in Cancer Pain Study

Yvan Beaussant, MD, MSci

NCT06001749

ACTIVE NOT RECRUITING Phase 1 731 participants

Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

Mirati Therapeutics

NCT03785249

ACTIVE NOT RECRUITING Phase 1 499 participants

Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer

Agenus

NCT03860272

ACTIVE NOT RECRUITING Phase 2 309 participants

A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer

Eli Lilly and Company

NCT02711553

ACTIVE NOT RECRUITING Phase 1 278 participants

Phase I Trial of Bevacizumab and Temsirolimus in Combination With 1) Carboplatin, 2) Paclitaxel, 3) Sorafenib for the Treatment of Advanced Cancer

M.D. Anderson Cancer Center

NCT01187199

ACTIVE NOT RECRUITING Phase 2 257 participants

Intrapleural Catheter Daily Versus Three Times a Week Drainage

M.D. Anderson Cancer Center

NCT00761618

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Phase Distribution

PhaseTrial count
Phase 1 71
Phase 2 14
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Cancer Trial Landscape

123 indexed Advanced Cancer studies · 45 recruiting (37%).

Phase mix: 2 late (III/IV) vs 85 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (19 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Cancer?

PlainTrial tracks 123 US clinical trials for Advanced Cancer, of which 45 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.