Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02193295 · ClinicalTrials.gov registry record · NA
Reversal of Lipid-Induced Insulin Resistance
A NA study of Insulin Resistance and NAFLD, sponsored by Yale University.
- Recruiting
- Registry status
- NA
- Development phase
- 250
- Enrollment target
- 2
- Study locations
NCT02193295: Recruiting NA study of Insulin Resistance and NAFLD, sponsored by Yale University.
NCT02193295 is a NA study of Insulin Resistance and NAFLD that is actively recruiting participants, run by Yale University. The registered enrollment target is 250 participants, roughly in line with the 243-participant average among 120 other Insulin Resistance trials with a reported enrollment target. The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02193295, a NA study of Insulin Resistance and NAFLD, is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- NA
- Development phase
- 250 participants
- Enrollment target
- 2
- Study locations
Study Summary
The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have a family history of type 2 diabetes. Hepatic mitochondrial oxidation will be assesses using a 3 hour triple tracer study (D7 glucose, 3-13C lactate and 13C4 beta-hydroxybutyrate).
Primary Outcome
Insulin sensitivity will be assessed using the insulin/glucose clamp, liver and muscle fat will be measured using 1H magnetic resonance spectroscopy (MRS) and both results from the clamp and MRS compared to baseline values before the weight reduction intervention.
Conditions Studied
Interventions
- BEHAVIORAL Caloric Restriction
Study Locations (2)
Connecticut
- Magnetic Resonance Research Center (MRRC) - New Haven
- Yale Center for Clinical Investigation HRU - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2002-10 |
| Est. Completion | 2034-12 |
| Phase | NA |
What NCT02193295 shows while recruiting
NCT02193295 is an interventional study that assigns participants to a tested intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 243-participant average among 120 other Insulin Resistance trials with a reported enrollment target.
The record links to 2 conditions, with Insulin Resistance appearing as the primary indexed condition, and to 1 intervention - of which Caloric Restriction is the first listed.
NCT02193295 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT02193295 about?
NCT02193295 is a clinical study titled "Reversal of Lipid-Induced Insulin Resistance". The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have a family history of type 2 diabetes. Hepatic mitochondrial oxidation w...
What is the current status of trial NCT02193295?
This trial is currently recruiting. It is a NA study. The enrollment target is 250 participants. The study started on 2002-10. Estimated completion is 2034-12.
What conditions does trial NCT02193295 study?
This clinical trial studies the following conditions: Insulin Resistance, NAFLD.
What interventions are being tested in trial NCT02193295?
The interventions under investigation include: Caloric Restriction (BEHAVIORAL).
Who is sponsoring clinical trial NCT02193295?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02193295 being conducted?
This trial has 2 study locations across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Insulin Resistance
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02193295's enrollment target sits among peer trials
250 8th of 120 higher than 112 of 120 other Insulin Resistance trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Insulin Resistance trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Metabolic Adaptations to Weight Loss With and Without Exercise
RECRUITING · NA
-
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
RECRUITING · NA
-
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
RECRUITING · NA
-
Small Extracellular Vesicles and Insulin Action
RECRUITING · NA
-
Exercise Effects on Adipose Tissue Structure and Function
RECRUITING · NA
-
New Mechanisms of Obesity
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00483249 · 250 participants · NA
Endovascular Exclusion of Thoracoabdominal and/or Paravisceral Abdominal Aortic Aneurysm
- NCT00777712 · 250 participants
Mechanisms Underlying Impaired Diabetic Wound Healing
- NCT01451502 · 250 participants · NA
Infusion of Cell Populations From Unlicensed Umbilical Cord Blood Units
- NCT01771718 · 250 participants
Pilot Study on In-vivo Non-invasive Skin Imaging Using Multiphoton Microscopy
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia