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ClinicalTrials.gov 45 recruiting now official registry

Ulcerative Colitis clinical trials

45 of 123 indexed Ulcerative Colitis trials are currently recruiting.

123 US clinical trials · 45 currently recruiting

Ulcerative Colitis is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 45 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 47 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 9 of these trials.

The research picture

Ulcerative Colitis has 123 registered US clinical trials, 45 of them open to new participants right now, about 37% of the total.

45
recruiting participants now
37%
of trials open to enrollment
32
in Phase 3–4 (later-stage)
9
top sponsor: Eli Lilly and Company
Phase 115Phase 232Phase 328Phase 44

Active & Recent Trials

123 total, page 1 of 3

RECRUITING 1,000 participants

Registry and Biorepository for IBD in Central Texas

University of Texas at Austin

NCT04617184

RECRUITING 1,000 participants

Immune Regulation in Ulcerative Colitis or Crohn s Disease

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00001184

RECRUITING Phase 3 980 participants

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

Sanofi

NCT07184996

RECRUITING Phase 3 671 participants

A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

Sanofi

NCT07185009

RECRUITING Phase 2 645 participants

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

Spyre Therapeutics

NCT07012395

RECRUITING Phase 3 530 participants

A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab

AbbVie

NCT06880744

RECRUITING Phase 2 480 participants

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

Diwakar Davar

NCT07223424

RECRUITING Phase 4 400 participants

A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

Takeda

NCT06581328

RECRUITING Phase 3 350 participants

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

Eli Lilly and Company

NCT06937086

RECRUITING 300 participants

A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease

TScan Therapeutics

NCT06587828

RECRUITING Phase 2 252 participants

LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

Eli Lilly and Company

NCT07186101

RECRUITING NA 250 participants

Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission

University of California, San Diego

NCT05230173

RECRUITING Phase 3 240 participants

A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

Takeda

NCT05442567

RECRUITING Phase 2 224 participants

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

Genentech

NCT06979336

RECRUITING Phase 2 207 participants

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis

Takeda

NCT06254950

RECRUITING 200 participants

Study of Efficacy and Adherence to Subcutaneous vs. Intravenous Vedolizumab in Patients With Inflammatory Bowel Disease Using a Novel Remote MONITORing Intervention

Mercy Medical Center

NCT06750731

RECRUITING 200 participants

Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation (STRIDE)

Seattle Children's Hospital

NCT06315179

RECRUITING Phase 2 183 participants

A Continuation Study of TAK-279 in Adults With Ulcerative Colitis (UC) and Crohn's Disease (CD)

Takeda

NCT06764615

RECRUITING Phase 2 176 participants

Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis

Gilead Sciences

NCT06029972

RECRUITING Phase 3 150 participants

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

Eli Lilly and Company

NCT04844606

RECRUITING Phase 2 140 participants

A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

Eli Lilly and Company

NCT06598943

RECRUITING NA 137 participants

BOOM-IBD2 Pivotal Clinical Trial

Boomerang Medical

NCT06571669

RECRUITING NA 126 participants

Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

Northwestern University

NCT05987852

RECRUITING NA 122 participants

Tailored Anti-Inflammatory (A-I) Diet for Americans With Ulcerative Colitis (UC)

University of Miami

NCT06784323

RECRUITING Phase 3 120 participants

A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis

AbbVie

NCT07071519

RECRUITING Phase 1 116 participants

Pilot and Feasibility Study of 2'-FL as a Dietary Supplement in IBD Patients Receiving Stable Maintenance Anti-TNF Therapy

Children's Hospital Medical Center, Cincinnati

NCT03847467

RECRUITING 100 participants

Mirikizumab Real World Protocol

University of North Carolina, Chapel Hill

NCT06696014

RECRUITING Phase 2 99 participants

A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis

Sanofi

NCT06975722

RECRUITING NA 75 participants

The Influence of a Fasting Mimicking Diet on Ulcerative Colitis

Stanford University

NCT03615690

RECRUITING Phase 4 70 participants

Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Extended-release Tablets in Pediatric Subjects Aged 5 to 17 Years With Active, Mild to Moderate Ulcerative Colitis

Bausch Health Americas

NCT04314375

RECRUITING NA 70 participants

Impact of Prebiotics in Ulcerative Colitis

University of California, Los Angeles

NCT06495658

RECRUITING Phase 3 70 participants

A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease

Takeda

NCT06100289

RECRUITING NA 68 participants

IBD-Sleep: A Pilot Study Looking at Changes in Sleep Timing and IBD Symptoms

University of Michigan

NCT06094608

RECRUITING Phase 4 65 participants

A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)

Takeda

NCT06095128

RECRUITING Phase 3 60 participants

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Moderately to Severely or Active Ulcerative Colitis

Eli Lilly and Company

NCT05784246

RECRUITING 50 participants

High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy

Boston Children's Hospital

NCT04331639

RECRUITING NA 40 participants

Nicotinamide Riboside in Ulcerative Colitis

University of Pittsburgh

NCT05561738

RECRUITING Phase 1 36 participants

R-3750 in Patients With Mild to Moderate Ulcerative Colitis

Rise Therapeutics

NCT05666960

RECRUITING Phase 2 36 participants

A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis

Pfizer

NCT05287126

RECRUITING NA 21 participants

Fermented Food-Supplemented Diet in Ulcerative Colitis

Stanford University

NCT04401605

RECRUITING Phase 2 20 participants

Treatment of UC With Novel Therapeutics

Brigham and Women's Hospital

NCT06420375

RECRUITING Phase 2 20 participants

Study of Novel Therapeutics for Acute Remedy of Colitis

Brigham and Women's Hospital

NCT06420492

RECRUITING NA 12 participants

A Study of Endoscopic Sleeve Gastroplasty for Obesity in Ulcerative Colitis

Mayo Clinic

NCT05739162

RECRUITING 10 participants

Understanding Ozanimod's MOA Via Mass Cytometry in Ulcerative Colitis

University of California, San Diego

NCT06311123

RECRUITING Phase 1 10 participants

The Use of Butyrate Therapy in Pediatric Ulcerative Colitis

Children's Hospital Los Angeles

NCT05218850

ACTIVE NOT RECRUITING 15,000 participants

A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease

Target PharmaSolutions

NCT03251118

ACTIVE NOT RECRUITING 4,970 participants

A Multicenter, Prospective, Long-term, Observational Registry of Pediatric Patients With Inflammatory Bowel Disease

Janssen Biotech

NCT00606346

ACTIVE NOT RECRUITING 2,828 participants

A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Ulcerative Colitis and Their Infants

Bristol-Myers Squibb

NCT06126835

ACTIVE NOT RECRUITING Phase 3 1,173 participants

Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis

Alfasigma S.p.A.

NCT02914535

ACTIVE NOT RECRUITING Phase 3 1,116 participants

ABTECT - Maintenance

Abivax S.A.

NCT05535946

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Phase Distribution

PhaseTrial count
Phase 1 15
Phase 2 32
Phase 3 28
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Ulcerative Colitis Trial Landscape

123 indexed Ulcerative Colitis studies · 45 recruiting (37%).

Phase mix: 32 late (III/IV) vs 47 early (I/II).

Top sponsor: Eli Lilly and Company (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Ulcerative Colitis?

PlainTrial tracks 123 US clinical trials for Ulcerative Colitis, of which 45 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Ulcerative Colitis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.