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Ulcerative Colitis clinical trials
45 of 123 indexed Ulcerative Colitis trials are currently recruiting.
123 US clinical trials · 45 currently recruiting
Ulcerative Colitis is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 45 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 47 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 9 of these trials.
The research picture
Ulcerative Colitis has 123 registered US clinical trials, 45 of them open to new participants right now, about 37% of the total.
- 45
- recruiting participants now
- 37%
- of trials open to enrollment
- 32
- in Phase 3–4 (later-stage)
- 9
- top sponsor: Eli Lilly and Company
Active & Recent Trials
123 total, page 1 of 3
Registry and Biorepository for IBD in Central Texas
University of Texas at Austin
NCT04617184
Immune Regulation in Ulcerative Colitis or Crohn s Disease
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001184
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
Sanofi
NCT07184996
A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
Sanofi
NCT07185009
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
Spyre Therapeutics
NCT07012395
A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab
AbbVie
NCT06880744
Patient Preference for Subcutaneous vs. Intravenous Immune Therapy
Diwakar Davar
NCT07223424
A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting
Takeda
NCT06581328
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
Eli Lilly and Company
NCT06937086
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
TScan Therapeutics
NCT06587828
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
Eli Lilly and Company
NCT07186101
Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission
University of California, San Diego
NCT05230173
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
Takeda
NCT05442567
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Genentech
NCT06979336
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis
Takeda
NCT06254950
Study of Efficacy and Adherence to Subcutaneous vs. Intravenous Vedolizumab in Patients With Inflammatory Bowel Disease Using a Novel Remote MONITORing Intervention
Mercy Medical Center
NCT06750731
Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation (STRIDE)
Seattle Children's Hospital
NCT06315179
A Continuation Study of TAK-279 in Adults With Ulcerative Colitis (UC) and Crohn's Disease (CD)
Takeda
NCT06764615
Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis
Gilead Sciences
NCT06029972
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
Eli Lilly and Company
NCT04844606
A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis
Eli Lilly and Company
NCT06598943
BOOM-IBD2 Pivotal Clinical Trial
Boomerang Medical
NCT06571669
Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)
Northwestern University
NCT05987852
Tailored Anti-Inflammatory (A-I) Diet for Americans With Ulcerative Colitis (UC)
University of Miami
NCT06784323
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
AbbVie
NCT07071519
Pilot and Feasibility Study of 2'-FL as a Dietary Supplement in IBD Patients Receiving Stable Maintenance Anti-TNF Therapy
Children's Hospital Medical Center, Cincinnati
NCT03847467
Mirikizumab Real World Protocol
University of North Carolina, Chapel Hill
NCT06696014
A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis
Sanofi
NCT06975722
The Influence of a Fasting Mimicking Diet on Ulcerative Colitis
Stanford University
NCT03615690
Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Extended-release Tablets in Pediatric Subjects Aged 5 to 17 Years With Active, Mild to Moderate Ulcerative Colitis
Bausch Health Americas
NCT04314375
Impact of Prebiotics in Ulcerative Colitis
University of California, Los Angeles
NCT06495658
A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease
Takeda
NCT06100289
IBD-Sleep: A Pilot Study Looking at Changes in Sleep Timing and IBD Symptoms
University of Michigan
NCT06094608
A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)
Takeda
NCT06095128
A Study of Mirikizumab (LY3074828) in Pediatric Participants With Moderately to Severely or Active Ulcerative Colitis
Eli Lilly and Company
NCT05784246
High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy
Boston Children's Hospital
NCT04331639
Nicotinamide Riboside in Ulcerative Colitis
University of Pittsburgh
NCT05561738
R-3750 in Patients With Mild to Moderate Ulcerative Colitis
Rise Therapeutics
NCT05666960
A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis
Pfizer
NCT05287126
Fermented Food-Supplemented Diet in Ulcerative Colitis
Stanford University
NCT04401605
Treatment of UC With Novel Therapeutics
Brigham and Women's Hospital
NCT06420375
Study of Novel Therapeutics for Acute Remedy of Colitis
Brigham and Women's Hospital
NCT06420492
A Study of Endoscopic Sleeve Gastroplasty for Obesity in Ulcerative Colitis
Mayo Clinic
NCT05739162
Understanding Ozanimod's MOA Via Mass Cytometry in Ulcerative Colitis
University of California, San Diego
NCT06311123
The Use of Butyrate Therapy in Pediatric Ulcerative Colitis
Children's Hospital Los Angeles
NCT05218850
A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease
Target PharmaSolutions
NCT03251118
A Multicenter, Prospective, Long-term, Observational Registry of Pediatric Patients With Inflammatory Bowel Disease
Janssen Biotech
NCT00606346
A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Ulcerative Colitis and Their Infants
Bristol-Myers Squibb
NCT06126835
Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis
Alfasigma S.p.A.
NCT02914535
ABTECT - Maintenance
Abivax S.A.
NCT05535946
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 32 |
| Phase 3 | 28 |
| Phase 4 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Ulcerative Colitis Trial Landscape
123 indexed Ulcerative Colitis studies · 45 recruiting (37%).
Phase mix: 32 late (III/IV) vs 47 early (I/II).
Top sponsor: Eli Lilly and Company (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Ulcerative Colitis?
PlainTrial tracks 123 US clinical trials for Ulcerative Colitis, of which 45 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Ulcerative Colitis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.