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ClinicalTrials.gov 32 recruiting now official registry

Insulin Resistance clinical trials

32 of 122 indexed Insulin Resistance trials are currently recruiting.

122 US clinical trials · 32 currently recruiting

Insulin Resistance is the subject of 122 registered US clinical trials on ClinicalTrials.gov, 32 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 7 of these trials.

The research picture

Insulin Resistance has 122 registered US clinical trials, 32 of them open to new participants right now, about 26% of the total.

32
recruiting participants now
26%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
7
top sponsor: Washington University School of Medicine
Phase 115Phase 27Phase 32Phase 48

Active & Recent Trials

122 total, page 2 of 3

ACTIVE NOT RECRUITING NA 7 participants

Probiotics and Insulin Resistance in Obese Asthmatics

University of Alabama at Birmingham

NCT05949255

COMPLETED Phase 2 300 participants

A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes)

National Center for Research Resources (NCRR)

NCT00015626

COMPLETED Phase 2 261 participants

Effects of Resistance and Aerobic Exercise on Cardiovascular Health

Duke University

NCT00275145

COMPLETED 166 participants

Regional Fat Depots and Insulin Resistance

Stanford University

NCT01336777

COMPLETED Phase 2 152 participants

Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT05017571

COMPLETED 146 participants

Identifying Risk for Diabetes and Heart Disease in Women

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT01809288

COMPLETED NA 142 participants

Financial Incentives to Exercise for Adolescents

University of Oklahoma

NCT01848353

COMPLETED Phase 4 140 participants

Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00212290

COMPLETED NA 120 participants

Effects of Atypical Antipsychotic and Valproate Combination Therapy on Glucose and Lipid Metabolism in Schizophrenia

Washington University School of Medicine

NCT00552500

COMPLETED NA 113 participants

Aerobic Plus Resistance Training and Insulin Sensitivity in African American Men

Pennington Biomedical Research Center

NCT01787617

COMPLETED Phase 4 104 participants

The Health Influences of Puberty (HIP) Study

University of Colorado, Denver

NCT01775813

COMPLETED NA 102 participants

Effects of Omega-3 Fatty Acids on Markers of Inflammation

Stanford University

NCT01129050

COMPLETED NA 97 participants

The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults

Yale University

NCT02335021

COMPLETED Phase 1 79 participants

Study to Evaluate Safety, Tolerability, and Pharmacokinetics of BFKB8488A in Otherwise Healthy Overweight and Obese Participants With Likely Insulin Resistance

Genentech

NCT02593331

COMPLETED Phase 4 77 participants

Ziprasidone for Improving Insulin Sensitivity in People With Schizophrenia Who Are at Risk for Diabetes

Veterans Medical Research Foundation

NCT00338949

COMPLETED NA 75 participants

Chromium and Insulin Resistance

University of California, San Francisco

NCT00846248

COMPLETED Phase 3 73 participants

A Trial of Tadalafil and Glycemic Traits

Thomas J. Wang, MD

NCT01444651

COMPLETED NA 72 participants

The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis (DAIRY Study)

Fred Hutchinson Cancer Center

NCT02663544

COMPLETED Phase 1 66 participants

Safety, Pharmacokinetics and Potential Activity of HE3286 in Obese Adult Subjects

Harbor Therapeutics

NCT00555451

COMPLETED 61 participants

Assessment of Insulin Resistance, NAFLD, Predictors of CV Morbidity, and Subcutaneous Adipose and Visceral Adipose Gene Expression in Patients Undergoing Gastric Bypass Surgery

University of Massachusetts, Worcester

NCT01007955

COMPLETED Phase 4 60 participants

A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin

Daiichi Sankyo

NCT00185094

COMPLETED NA 60 participants

Macronutrient Effects on Alzheimer's Disease (MEAL-2)

Wake Forest University Health Sciences

NCT02463084

COMPLETED NA 59 participants

Progressive Weight Loss and Metabolic Health

Washington University School of Medicine

NCT01299519

COMPLETED NA 58 participants

Molecular Mechanisms of Exercise Benefits to Insulin Resistant People

Mayo Clinic

NCT04158375

COMPLETED 57 participants

Insulin Resistance in Patients With Major Depression

Stanford University

NCT01106313

COMPLETED NA 56 participants

Biologic Effects of Dehydroepiandrosterone (DHEA) in Humans

National Institute on Aging (NIA)

NCT00099697

COMPLETED NA 54 participants

Grains Reduce Adiposity and Improve Nutrition Study

Penn State University

NCT00924521

COMPLETED NA 53 participants

Timing Estrogen After MenoPaUSe

University of Colorado, Denver

NCT01605071

COMPLETED NA 52 participants

Effects of Exercise Training Intensity on Fitness and Insulin Sensitivity in African Americans

East Carolina University

NCT02892331

COMPLETED 48 participants

Fasting for Brain and Heart Health (FBHH)

TrueNorth Health Foundation

NCT04507516

COMPLETED 47 participants

Novel Therapy for Glucose Intolerance in HIV Disease

Stony Brook University

NCT02006914

COMPLETED Phase 4 46 participants

Oral Contraceptives in the Metabolic Syndrome

Virginia Commonwealth University

NCT00205504

COMPLETED 43 participants

Metabolic Parameters 3 Months, 9 Months, and 2 Years After Bariatric Surgery

The University of Texas Health Science Center, Houston

NCT00178633

COMPLETED NA 41 participants

Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.

Yale University

NCT02196051

COMPLETED NA 40 participants

Developing an Adaptive Lifestyle Intervention Program in Family Medicine Clinics

University of Alabama at Birmingham

NCT04392284

COMPLETED NA 40 participants

Continuous Glucose Monitors (CGM) for Type 2 Diabetes (T2D) Risk Evaluation

Mary Ellen Vajravelu, MD

NCT05404711

COMPLETED Phase 2 40 participants

Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults

University Hospitals Cleveland Medical Center

NCT01046682

COMPLETED NA 39 participants

Yoga Improves Aerobic Fitness, Glycemia and Mood State and Reduces Abdominal Obesity

Skidmore College

NCT02190136

COMPLETED 39 participants

Predictors of Response to Fenofibrate

University of Alabama at Birmingham

NCT01023750

COMPLETED NA 37 participants

Effects of Hepatic Ultrasound on Metabolic Homeostasis

Yale University

NCT04622683

COMPLETED Phase 4 37 participants

Pioglitazone in Patients With Mood Disorders

Stanford University

NCT01559857

COMPLETED NA 36 participants

12 Weeks of Resistance Band Exercise Impacts on Metabolic Syndrome Progression in Postmenopausal Women

Pusan National University

NCT04014686

COMPLETED NA 33 participants

Effects of Fish Oils on Inflammation and Insulin Resistance

Philip Kern

NCT00579436

COMPLETED NA 32 participants

Effects of Hi-maize Resistant Starch on Insulin Sensitivity

Ingredion Incorporated

NCT01058135

COMPLETED NA 32 participants

Effects of Consuming Sugar-Sweetened Beverages With Meals for 10 Weeks

University of California, Davis

NCT01165853

COMPLETED NA 31 participants

Mitochondrial Remodeling After Exercise

Oregon State University

NCT04103424

COMPLETED Phase 4 30 participants

Study of Niacin and Rosiglitazone in Dysmetabolic Dyslipidemia

Foundation Research, Florida

NCT00304993

COMPLETED NA 30 participants

Blood Flow Responses to an Oral Glucose Tolerance Test in Type 2 Diabetes

University of Kansas Medical Center

NCT00972452

COMPLETED 30 participants

The Incidence and Treatment of Insulin Resistance Among Men With Erectile Dysfunction

Milton S. Hershey Medical Center

NCT00284960

COMPLETED Phase 3 30 participants

Hydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid Arthritis

Brigham and Women's Hospital

NCT01132118

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Phase Distribution

PhaseTrial count
Phase 1 15
Phase 2 7
Phase 3 2
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Insulin Resistance Trial Landscape

122 indexed Insulin Resistance studies · 32 recruiting (26%).

Phase mix: 10 late (III/IV) vs 22 early (I/II).

Top sponsor: Washington University School of Medicine (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Insulin Resistance?

PlainTrial tracks 122 US clinical trials for Insulin Resistance, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Insulin Resistance?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.