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Insulin Resistance clinical trials
32 of 122 indexed Insulin Resistance trials are currently recruiting.
122 US clinical trials · 32 currently recruiting
Insulin Resistance is the subject of 122 registered US clinical trials on ClinicalTrials.gov, 32 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 7 of these trials.
The research picture
Insulin Resistance has 122 registered US clinical trials, 32 of them open to new participants right now, about 26% of the total.
- 32
- recruiting participants now
- 26%
- of trials open to enrollment
- 10
- in Phase 3–4 (later-stage)
- 7
- top sponsor: Washington University School of Medicine
Active & Recent Trials
122 total, page 2 of 3
Probiotics and Insulin Resistance in Obese Asthmatics
University of Alabama at Birmingham
NCT05949255
A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes)
National Center for Research Resources (NCRR)
NCT00015626
Effects of Resistance and Aerobic Exercise on Cardiovascular Health
Duke University
NCT00275145
Regional Fat Depots and Insulin Resistance
Stanford University
NCT01336777
Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT05017571
Identifying Risk for Diabetes and Heart Disease in Women
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT01809288
Financial Incentives to Exercise for Adolescents
University of Oklahoma
NCT01848353
Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00212290
Effects of Atypical Antipsychotic and Valproate Combination Therapy on Glucose and Lipid Metabolism in Schizophrenia
Washington University School of Medicine
NCT00552500
Aerobic Plus Resistance Training and Insulin Sensitivity in African American Men
Pennington Biomedical Research Center
NCT01787617
The Health Influences of Puberty (HIP) Study
University of Colorado, Denver
NCT01775813
Effects of Omega-3 Fatty Acids on Markers of Inflammation
Stanford University
NCT01129050
The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults
Yale University
NCT02335021
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of BFKB8488A in Otherwise Healthy Overweight and Obese Participants With Likely Insulin Resistance
Genentech
NCT02593331
Ziprasidone for Improving Insulin Sensitivity in People With Schizophrenia Who Are at Risk for Diabetes
Veterans Medical Research Foundation
NCT00338949
Chromium and Insulin Resistance
University of California, San Francisco
NCT00846248
A Trial of Tadalafil and Glycemic Traits
Thomas J. Wang, MD
NCT01444651
The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis (DAIRY Study)
Fred Hutchinson Cancer Center
NCT02663544
Safety, Pharmacokinetics and Potential Activity of HE3286 in Obese Adult Subjects
Harbor Therapeutics
NCT00555451
Assessment of Insulin Resistance, NAFLD, Predictors of CV Morbidity, and Subcutaneous Adipose and Visceral Adipose Gene Expression in Patients Undergoing Gastric Bypass Surgery
University of Massachusetts, Worcester
NCT01007955
A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin
Daiichi Sankyo
NCT00185094
Macronutrient Effects on Alzheimer's Disease (MEAL-2)
Wake Forest University Health Sciences
NCT02463084
Progressive Weight Loss and Metabolic Health
Washington University School of Medicine
NCT01299519
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People
Mayo Clinic
NCT04158375
Insulin Resistance in Patients With Major Depression
Stanford University
NCT01106313
Biologic Effects of Dehydroepiandrosterone (DHEA) in Humans
National Institute on Aging (NIA)
NCT00099697
Grains Reduce Adiposity and Improve Nutrition Study
Penn State University
NCT00924521
Timing Estrogen After MenoPaUSe
University of Colorado, Denver
NCT01605071
Effects of Exercise Training Intensity on Fitness and Insulin Sensitivity in African Americans
East Carolina University
NCT02892331
Fasting for Brain and Heart Health (FBHH)
TrueNorth Health Foundation
NCT04507516
Novel Therapy for Glucose Intolerance in HIV Disease
Stony Brook University
NCT02006914
Oral Contraceptives in the Metabolic Syndrome
Virginia Commonwealth University
NCT00205504
Metabolic Parameters 3 Months, 9 Months, and 2 Years After Bariatric Surgery
The University of Texas Health Science Center, Houston
NCT00178633
Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.
Yale University
NCT02196051
Developing an Adaptive Lifestyle Intervention Program in Family Medicine Clinics
University of Alabama at Birmingham
NCT04392284
Continuous Glucose Monitors (CGM) for Type 2 Diabetes (T2D) Risk Evaluation
Mary Ellen Vajravelu, MD
NCT05404711
Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults
University Hospitals Cleveland Medical Center
NCT01046682
Yoga Improves Aerobic Fitness, Glycemia and Mood State and Reduces Abdominal Obesity
Skidmore College
NCT02190136
Predictors of Response to Fenofibrate
University of Alabama at Birmingham
NCT01023750
Effects of Hepatic Ultrasound on Metabolic Homeostasis
Yale University
NCT04622683
Pioglitazone in Patients With Mood Disorders
Stanford University
NCT01559857
12 Weeks of Resistance Band Exercise Impacts on Metabolic Syndrome Progression in Postmenopausal Women
Pusan National University
NCT04014686
Effects of Fish Oils on Inflammation and Insulin Resistance
Philip Kern
NCT00579436
Effects of Hi-maize Resistant Starch on Insulin Sensitivity
Ingredion Incorporated
NCT01058135
Effects of Consuming Sugar-Sweetened Beverages With Meals for 10 Weeks
University of California, Davis
NCT01165853
Mitochondrial Remodeling After Exercise
Oregon State University
NCT04103424
Study of Niacin and Rosiglitazone in Dysmetabolic Dyslipidemia
Foundation Research, Florida
NCT00304993
Blood Flow Responses to an Oral Glucose Tolerance Test in Type 2 Diabetes
University of Kansas Medical Center
NCT00972452
The Incidence and Treatment of Insulin Resistance Among Men With Erectile Dysfunction
Milton S. Hershey Medical Center
NCT00284960
Hydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid Arthritis
Brigham and Women's Hospital
NCT01132118
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 7 |
| Phase 3 | 2 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Insulin Resistance Trial Landscape
122 indexed Insulin Resistance studies · 32 recruiting (26%).
Phase mix: 10 late (III/IV) vs 22 early (I/II).
Top sponsor: Washington University School of Medicine (7 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Insulin Resistance?
PlainTrial tracks 122 US clinical trials for Insulin Resistance, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Insulin Resistance?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.