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NCT06129110 · ClinicalTrials.gov registry record · NA
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
A NA study of Obesity and Insulin Resistance, sponsored by University of Colorado, Denver.
- Recruiting
- Registry status
- NA
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT06129110: Recruiting NA study of Obesity and Insulin Resistance, sponsored by University of Colorado, Denver.
NCT06129110 is a NA study of Obesity and Insulin Resistance that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 70 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06129110, a NA study of Obesity and Insulin Resistance, is actively recruiting participants, sponsored by University of Colorado, Denver.
- RECRUITING
- Registry status
- NA
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention. Researchers will then compare outcomes of individuals who lost weight to individuals who did not lose weight.
Primary Outcome
Participants will undergo a standard 3-hour hyperinsulinemic/euglycemic clamp with insulin infused at 80 mU/m2/min, and glucose clamped at 90 mg/dl with a variable dextrose infusion.
Conditions Studied
Interventions
- BEHAVIORAL Diet Weight Loss
Study Locations (1)
Colorado
- University of Colorado Anschutz - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2024-01-01 |
| Est. Completion | 2029-12-01 |
| Phase | NA |
What NCT06129110 shows while recruiting
NCT06129110 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (91% lower).
The record links to 5 conditions, with Obesity appearing as the primary indexed condition, and to 1 intervention - of which Diet Weight Loss is the first listed.
NCT06129110 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT06129110 about?
NCT06129110 is a clinical study titled "Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling". The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation,...
What is the current status of trial NCT06129110?
This trial is currently recruiting. It is a NA study. The enrollment target is 70 participants. The study started on 2024-01-01. Estimated completion is 2029-12-01.
What conditions does trial NCT06129110 study?
This clinical trial studies the following conditions: Obesity, Insulin Resistance, Insulin Sensitivity, Muscle Weakness, Adiposity.
What interventions are being tested in trial NCT06129110?
The interventions under investigation include: Diet Weight Loss (BEHAVIORAL).
Who is sponsoring clinical trial NCT06129110?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06129110 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obesity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06129110's enrollment target sits among peer trials
70 595th of 1053 higher than 449 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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