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NCT04984226 · ClinicalTrials.gov registry record · Phase 2
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
A Phase 2 study of Diabetes and Insulin Resistance, sponsored by University of California, Davis.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 80
- Enrollment target
- 2
- Study locations
NCT04984226: Recruiting Phase 2 study of Diabetes and Insulin Resistance, sponsored by University of California, Davis.
NCT04984226 is a Phase 2 study of Diabetes and Insulin Resistance that is actively recruiting participants, run by University of California, Davis. The registered enrollment target is 80 participants, below the 3,028-participant average among 338 other Diabetes trials with a reported enrollment target (97% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04984226, a Phase 2 study of Diabetes and Insulin Resistance, is actively recruiting participants, sponsored by University of California, Davis.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 80 participants
- Enrollment target
- 2
- Study locations
Study Summary
Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vivo tools to study the pathophysiology of poor physical endurance in a clinical trial treating metabolic acidosis among persons living with chronic kidney disease.
Primary Outcome
We will use 31P MRS to evaluate the concentration of phospho-creatine (PCr) and other phosphate-energy carrier molecules in limb muscles. After one minute of basal resting measurements, patients will be asked to perform two knee extensions every second against ankle weights 5-10% of the maximal voluntary contraction. The exercise protocol will last 60-90 seconds (a total of 60 knee extensions) followed by 6 minutes of rest. The intensity of the exercise decreases phosphocreatine (PCr) levels wit
Conditions Studied
Interventions
- DRUG placebo
- DRUG Sodium bicarbonate
Study Locations (2)
California
- University of California Davis Health - Sacramento
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2023-09-08 |
| Est. Completion | 2026-07-30 |
| Phase | Phase 2 |
What NCT04984226 shows while recruiting
NCT04984226 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 3,028-participant average among 338 other Diabetes trials with a reported enrollment target (97% lower).
The record links to 7 conditions, with Diabetes appearing as the primary indexed condition, and to 2 interventions - of which placebo is the first listed.
NCT04984226 reports a single indexed study location in California, Tennessee.
Frequently Asked Questions
What is clinical trial NCT04984226 about?
NCT04984226 is a clinical study titled "Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD". Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in viv...
What is the current status of trial NCT04984226?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2023-09-08. Estimated completion is 2026-07-30.
What conditions does trial NCT04984226 study?
This clinical trial studies the following conditions: Diabetes, Insulin Resistance, Fatigue, Chronic Kidney Diseases, Metabolic Acidosis.
What interventions are being tested in trial NCT04984226?
The interventions under investigation include: placebo (DRUG), Sodium bicarbonate (DRUG).
Who is sponsoring clinical trial NCT04984226?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04984226 being conducted?
This trial has 2 study locations across California, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Diabetes
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04984226's enrollment target sits among peer trials
80 212th of 338 higher than 124 of 338 other Diabetes trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diabetes trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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