Brigham and Women's Hospital
Trial Pipeline
Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES)
NCT07427043
Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms
NCT07136415
Mindfulness Meditation for Insomnia
NCT06972303
Yoga for Persistent Post-Surgical Pain (PPSP)
NCT06949007
OsteoPorotic fracTure preventION System (OPTIONS) Research Study
NCT06731608
Acute Psychiatric Care at Home for Lower-risk Patients With Acute Psychiatric Illness Who Require Inpatient Care
NCT07364825
Efficacy of Routine Saline Flushing in the Prevention of Nephrostomy Tube Obstructions: A Pilot Study
NCT06987877
Targeted Accelerated TMS for Post-Traumatic Stress Disorder
NCT07245641
Targeted Naltrexone to Support Individuals Participating in Dry January
NCT07132177
Self-regulation of Real-time fMRI Brain Activity in Chronic Pain
NCT07023523
Extended-release Buprenorphine as a Novel Low-dose Induction Strategy
NCT06441604
Losartan to Improve Outcomes After Multi-ligament Knee Injury
NCT06933706
Study of Novel Therapeutics for Acute Remedy of Colitis
NCT06420492
Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease
NCT06489548
Study of Tirzepatide for Recovery and Alcohol Use Management
NCT06727331
Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool
NCT07193524
Using Reinforcement Learning to Personalize Electronic Health Record Tools to Facilitate Deprescribing
NCT06660979
Accelerated TMS for Perinatal Depression
NCT06968390
Quality of Life in Patients With Postoperative Atrial Fibrillation After Cardiac Surgery
NCT07173998
Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates
NCT07275021
Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain
NCT06632535
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
NCT06854458
Cocoa Extract for Migraine Trial
NCT06808230
Evaluating Informatics-assisted Immune-related Adverse Event Detection to Improve Registration Onto a Biorepository
NCT06789601
Semaglutide for Helping Opioid Recovery
NCT06639464
Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy
NCT06483659
Glucose Consumption in MS Using [F-18]FDG-PET
NCT07087106
Short Course Radiation Treatment for Patients With Primary or Locally Recurrent Retroperitoneal Sarcoma Prior to Surgery
NCT06812052
Assessment of Circuit Rebreathing During CPAP Therapy
NCT07062770
Treatment of UC With Novel Therapeutics
NCT06420375
Practical Geriatric Assessment in Older Adults With Non-Small Cell Lung Cancer Undergoing Stereotactic Body Radiation Therapy
NCT06987890
The Impact of Music Medicine on Preterm Brain Development and Behavior
NCT06536296
Assessment of Synaptic Density in MS
NCT04634994
Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine
NCT06795867
Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial
NCT06835803
Computerized Decision Support for Identification and Management of Familial Hypercholesterolemia
NCT06743659
Chiropractic Care for Episodic Migraine
NCT06229834
Refinement and Testing of Recruitment Methodology for Behavioral Medication Adherence Interventions Using Behavioral Science-based Approaches
NCT06569290
The Anabolic Effect of Testosterone on Pelvic Floor Muscles
NCT06111209
Safety and Feasibility of Tele-supervised Home-based Transcranial Direct Current Stimulation in Parkinson's Disease
NCT06804668
Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
NCT06376734
Embolization Treatment of Chronic Refractory Shoulder Tendinopathy
NCT06095050
Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities
NCT06989619
Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors
NCT06328127
Can Food Timing Reduce Your Diabetes Risk?
NCT05862818
Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
NCT06105164
Eating to Adjust the Timing System
NCT05800990
Elranatamab in Patients With Relapsed or Refractory AL Amyloidosis
NCT06569147
Effect of Physical Activity Pattern on Cardiometabolic Health
NCT05838508
Care Transitions App for Patients With Multiple Chronic Conditions
NCT06051058
LIFT: Life Improvement Trial
NCT06366724
The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study
NCT07315997
AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention
NCT06235112
Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens
NCT06252129
Exercise Training in Transthyretin Cardiac Amyloidosis
NCT05797857
Understanding the Acute Pain Phenotype in Patients Undergoing Surgery
NCT06466941
Novel Treatments in Improving Renal Outcomes in Light Chain Cast Nephropathy
NCT06483139
Experiment 2: One Target in Many Situations
NCT06934148
Mixed Vs Blocked Search: Four Unique Tasks
NCT06933693
Experiment 3: Mixed vs Blocked; Dashboard Paradigm
NCT06934213
Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease
NCT06190158
Study on Allopregnanolone and Depression in Women Across the Menopause Transition
NCT06238700
Ergonomics in the Cardiac Catheterization Laboratory
NCT06506968
Preventing Injured Knees From osteoArthritis: Severity Outcomes
NCT06096259
A Hybrid Effectiveness Implementation Trial Evaluating Behavioral Treatments for Insomnia for Socioeconomically Disadvantaged Adults in Primary Care
NCT05759065
Pilot of 18F-DCFPyL-PSMA PET in mCRPC Patients Receiving 117Lu-Vipivotide Tetraxetan
NCT06099093
Digital Health Navigation for Latino Patients With Type II Diabetes
NCT06283992
Reversible Effect of Falling Ventilatory Drive in Drive-dependent OSA
NCT06091098
Manual Versus AI-Assisted Clinical Trial Screening Using Large-Language Models
NCT06588452
Pilot Study for Detection of PSMA-Low CRPC-NE Tumors With Fluciclovine PET/CT
NCT06062745
Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA
NCT06091085
Trazodone on OSA Endotypes
NCT06286189
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
NCT06538376
Detoxification of the Liver In PSC (Dolphin)
NCT05835505
ED90 of Bupivacaine After Lidocaine Test Dose with DPE and EPL
NCT06146842
Pilot Testing a Novel Remotely Delivered Intensive Outpatient Program for Individuals With OUD
NCT05817825
Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers
NCT05553782
Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment
NCT06069622
Down Syndrome Obstructive Sleep Apnea
NCT06043440
Impact of Intensive Computerized Cognitive Training
NCT06130735
MCT for the Harvard/UCSF ROBIN Center
NCT06000787
Cerebellar TMS and Satiety in Prader-Willi Syndrome
NCT05938543
Ultrasound Therapy In Cardiac Amyloidosis
NCT04667494
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension
NCT05593055
Trial of Variable Dialysate Bicarbonate
NCT05814146
MRI Guided Prostate Biopsy
NCT06302595
Rescue Pharmacotherapy for OSA
NCT05293600
Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II
NCT05555875
NAD Augmentation in Diabetes Kidney Disease
NCT05759468
MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI
NCT05730816
Dietary Intervention to Mitigate Adverse Consequences of Night Work
NCT04868526
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
NCT07222683
Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy
NCT06300450
PREventing Pain After Surgery
NCT05306665
Efficacy of Suvorexant in the Treatment of Insomnia in Midlife Women With Pre-Diabetes
NCT05593653
Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis
NCT05619302
Testing Effects of Melatonin on Uterine Contractions in Women
NCT05358834
SmartSteps: A Context-Aware, PrEP Adherence Intervention for Individuals With Substance Use Disorder
NCT05378399
Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study
NCT05030545
Microdevice In Ovarian, Fallopian Tube, And Peritoneal Cancer
NCT04701645
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 95 |
| Phase 2 | 107 |
| Phase 3 | 47 |
| Phase 4 | 87 |
Therapeutic Areas
What the Pipeline for Brigham and Women's Hospital Shows
According to the ClinicalTrials.gov registry, Brigham and Women's Hospital is linked to 929 US clinical trials across every stage of research activity. Of those, 691 studies are currently recruiting — about 74% of the sponsor's indexed portfolio — and 156 are already marked complete, representing roughly 17% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for Brigham and Women's Hospital reports 134 late-stage studies (Phase 3 and Phase 4 combined) and 202 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for Brigham and Women's Hospital is Hypertension with 12 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.