Brigham and Women's Hospital

929 total trials 691 currently recruiting 156 completed

Trial Pipeline

RECRUITING Phase 3

Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES)

NCT07427043

RECRUITING Phase 4

Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms

NCT07136415

RECRUITING Phase 1

Mindfulness Meditation for Insomnia

NCT06972303

RECRUITING NA

Yoga for Persistent Post-Surgical Pain (PPSP)

NCT06949007

RECRUITING NA

OsteoPorotic fracTure preventION System (OPTIONS) Research Study

NCT06731608

RECRUITING NA

Acute Psychiatric Care at Home for Lower-risk Patients With Acute Psychiatric Illness Who Require Inpatient Care

NCT07364825

RECRUITING NA

Efficacy of Routine Saline Flushing in the Prevention of Nephrostomy Tube Obstructions: A Pilot Study

NCT06987877

RECRUITING NA

Targeted Accelerated TMS for Post-Traumatic Stress Disorder

NCT07245641

RECRUITING Phase 2

Targeted Naltrexone to Support Individuals Participating in Dry January

NCT07132177

RECRUITING NA

Self-regulation of Real-time fMRI Brain Activity in Chronic Pain

NCT07023523

RECRUITING Phase 2

Extended-release Buprenorphine as a Novel Low-dose Induction Strategy

NCT06441604

RECRUITING Phase 2

Losartan to Improve Outcomes After Multi-ligament Knee Injury

NCT06933706

RECRUITING Phase 2

Study of Novel Therapeutics for Acute Remedy of Colitis

NCT06420492

RECRUITING Phase 2

Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease

NCT06489548

RECRUITING Phase 2

Study of Tirzepatide for Recovery and Alcohol Use Management

NCT06727331

RECRUITING NA

Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool

NCT07193524

RECRUITING NA

Using Reinforcement Learning to Personalize Electronic Health Record Tools to Facilitate Deprescribing

NCT06660979

RECRUITING NA

Accelerated TMS for Perinatal Depression

NCT06968390

RECRUITING

Quality of Life in Patients With Postoperative Atrial Fibrillation After Cardiac Surgery

NCT07173998

RECRUITING

Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates

NCT07275021

RECRUITING NA

Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain

NCT06632535

RECRUITING NA

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

NCT06854458

RECRUITING NA

Cocoa Extract for Migraine Trial

NCT06808230

RECRUITING Phase 1

Evaluating Informatics-assisted Immune-related Adverse Event Detection to Improve Registration Onto a Biorepository

NCT06789601

RECRUITING Phase 2

Semaglutide for Helping Opioid Recovery

NCT06639464

RECRUITING Phase 2

Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy

NCT06483659

RECRUITING Phase 4

Glucose Consumption in MS Using [F-18]FDG-PET

NCT07087106

RECRUITING Phase 1

Short Course Radiation Treatment for Patients With Primary or Locally Recurrent Retroperitoneal Sarcoma Prior to Surgery

NCT06812052

RECRUITING NA

Assessment of Circuit Rebreathing During CPAP Therapy

NCT07062770

RECRUITING Phase 2

Treatment of UC With Novel Therapeutics

NCT06420375

RECRUITING NA

Practical Geriatric Assessment in Older Adults With Non-Small Cell Lung Cancer Undergoing Stereotactic Body Radiation Therapy

NCT06987890

RECRUITING NA

The Impact of Music Medicine on Preterm Brain Development and Behavior

NCT06536296

RECRUITING Early Phase 1

Assessment of Synaptic Density in MS

NCT04634994

RECRUITING NA

Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine

NCT06795867

RECRUITING Phase 2

Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial

NCT06835803

RECRUITING NA

Computerized Decision Support for Identification and Management of Familial Hypercholesterolemia

NCT06743659

RECRUITING NA

Chiropractic Care for Episodic Migraine

NCT06229834

RECRUITING NA

Refinement and Testing of Recruitment Methodology for Behavioral Medication Adherence Interventions Using Behavioral Science-based Approaches

NCT06569290

RECRUITING Phase 2

The Anabolic Effect of Testosterone on Pelvic Floor Muscles

NCT06111209

RECRUITING NA

Safety and Feasibility of Tele-supervised Home-based Transcranial Direct Current Stimulation in Parkinson's Disease

NCT06804668

RECRUITING Phase 2

Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

NCT06376734

RECRUITING NA

Embolization Treatment of Chronic Refractory Shoulder Tendinopathy

NCT06095050

RECRUITING NA

Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities

NCT06989619

RECRUITING NA

Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors

NCT06328127

RECRUITING NA

Can Food Timing Reduce Your Diabetes Risk?

NCT05862818

RECRUITING NA

Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

NCT06105164

RECRUITING NA

Eating to Adjust the Timing System

NCT05800990

RECRUITING Phase 1

Elranatamab in Patients With Relapsed or Refractory AL Amyloidosis

NCT06569147

RECRUITING NA

Effect of Physical Activity Pattern on Cardiometabolic Health

NCT05838508

RECRUITING NA

Care Transitions App for Patients With Multiple Chronic Conditions

NCT06051058

RECRUITING Phase 2

LIFT: Life Improvement Trial

NCT06366724

RECRUITING

The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study

NCT07315997

RECRUITING NA

AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention

NCT06235112

RECRUITING NA

Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens

NCT06252129

RECRUITING NA

Exercise Training in Transthyretin Cardiac Amyloidosis

NCT05797857

RECRUITING

Understanding the Acute Pain Phenotype in Patients Undergoing Surgery

NCT06466941

RECRUITING

Novel Treatments in Improving Renal Outcomes in Light Chain Cast Nephropathy

NCT06483139

RECRUITING NA

Experiment 2: One Target in Many Situations

NCT06934148

RECRUITING NA

Mixed Vs Blocked Search: Four Unique Tasks

NCT06933693

RECRUITING NA

Experiment 3: Mixed vs Blocked; Dashboard Paradigm

NCT06934213

RECRUITING Early Phase 1

Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease

NCT06190158

RECRUITING NA

Study on Allopregnanolone and Depression in Women Across the Menopause Transition

NCT06238700

RECRUITING

Ergonomics in the Cardiac Catheterization Laboratory

NCT06506968

RECRUITING Phase 2

Preventing Injured Knees From osteoArthritis: Severity Outcomes

NCT06096259

RECRUITING NA

A Hybrid Effectiveness Implementation Trial Evaluating Behavioral Treatments for Insomnia for Socioeconomically Disadvantaged Adults in Primary Care

NCT05759065

RECRUITING Phase 4

Pilot of 18F-DCFPyL-PSMA PET in mCRPC Patients Receiving 117Lu-Vipivotide Tetraxetan

NCT06099093

RECRUITING NA

Digital Health Navigation for Latino Patients With Type II Diabetes

NCT06283992

RECRUITING NA

Reversible Effect of Falling Ventilatory Drive in Drive-dependent OSA

NCT06091098

RECRUITING

Manual Versus AI-Assisted Clinical Trial Screening Using Large-Language Models

NCT06588452

RECRUITING Phase 1

Pilot Study for Detection of PSMA-Low CRPC-NE Tumors With Fluciclovine PET/CT

NCT06062745

RECRUITING Phase 1

Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA

NCT06091085

RECRUITING Phase 1

Trazodone on OSA Endotypes

NCT06286189

RECRUITING NA

Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU

NCT06538376

RECRUITING Phase 2

Detoxification of the Liver In PSC (Dolphin)

NCT05835505

RECRUITING Phase 4

ED90 of Bupivacaine After Lidocaine Test Dose with DPE and EPL

NCT06146842

RECRUITING NA

Pilot Testing a Novel Remotely Delivered Intensive Outpatient Program for Individuals With OUD

NCT05817825

RECRUITING Early Phase 1

Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers

NCT05553782

RECRUITING

Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment

NCT06069622

RECRUITING Phase 2

Down Syndrome Obstructive Sleep Apnea

NCT06043440

RECRUITING NA

Impact of Intensive Computerized Cognitive Training

NCT06130735

RECRUITING NA

MCT for the Harvard/UCSF ROBIN Center

NCT06000787

RECRUITING NA

Cerebellar TMS and Satiety in Prader-Willi Syndrome

NCT05938543

RECRUITING Phase 4

Ultrasound Therapy In Cardiac Amyloidosis

NCT04667494

RECRUITING Phase 4

Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension

NCT05593055

RECRUITING NA

Trial of Variable Dialysate Bicarbonate

NCT05814146

RECRUITING NA

MRI Guided Prostate Biopsy

NCT06302595

RECRUITING Phase 1

Rescue Pharmacotherapy for OSA

NCT05293600

RECRUITING NA

Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II

NCT05555875

RECRUITING Phase 2

NAD Augmentation in Diabetes Kidney Disease

NCT05759468

RECRUITING Phase 2

MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI

NCT05730816

RECRUITING NA

Dietary Intervention to Mitigate Adverse Consequences of Night Work

NCT04868526

RECRUITING

The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease

NCT07222683

RECRUITING NA

Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy

NCT06300450

RECRUITING NA

PREventing Pain After Surgery

NCT05306665

RECRUITING Phase 4

Efficacy of Suvorexant in the Treatment of Insomnia in Midlife Women With Pre-Diabetes

NCT05593653

RECRUITING Phase 3

Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis

NCT05619302

RECRUITING NA

Testing Effects of Melatonin on Uterine Contractions in Women

NCT05358834

RECRUITING Phase 3

SmartSteps: A Context-Aware, PrEP Adherence Intervention for Individuals With Substance Use Disorder

NCT05378399

RECRUITING Phase 4

Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study

NCT05030545

RECRUITING Phase 1

Microdevice In Ovarian, Fallopian Tube, And Peritoneal Cancer

NCT04701645

Phase Distribution

PhaseTrial count
Phase 1 95
Phase 2 107
Phase 3 47
Phase 4 87

What the Pipeline for Brigham and Women's Hospital Shows

According to the ClinicalTrials.gov registry, Brigham and Women's Hospital is linked to 929 US clinical trials across every stage of research activity. Of those, 691 studies are currently recruiting — about 74% of the sponsor's indexed portfolio — and 156 are already marked complete, representing roughly 17% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for Brigham and Women's Hospital reports 134 late-stage studies (Phase 3 and Phase 4 combined) and 202 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for Brigham and Women's Hospital is Hypertension with 12 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial