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Missouri: below-average open trial sites
1,339 of 4,116 in-state trials are recruiting (33%); below the 37% national average by 4 percentage points.
According to ClinicalTrials.gov-derived indexes, Missouri sits in the upper half of US states by in-state trial count (#17 of 52 states by registered in-state trial count).
Missouri: 4,116 US clinical trials with in-state sites, 1,339 recruiting.
Missouri has 4,116 registered US clinical trials with a study site in-state, 1,339 of them currently recruiting (below the 37% national average by 4 percentage points). 857 of these trials are in Phase 3 (late-stage) and 1,044 in Phase 2. The most frequently studied condition in Missouri is Breast Cancer, with 80 linked trials.
Mid-pack research density
Missouri sits in the upper half of the state corpus, so volume is meaningful but not hub-scale. Use condition and sponsor rollups below to see what drives the in-state mix.
Below-average open enrollment
Missouri still shows 1,339 recruiting of 4,116 in-state trials (33% open), but below the 37% national average by 4 percentage points, so archived statuses weigh heavier than the national baseline.
- 33%
- open (below national share)
- 1,339
- still recruiting despite cool share
- 1,044
- Phase 2 rows in this footprint
- 80
- top: Breast Cancer
Recruiting share is below the 37% national average by 4 percentage points. Counts include every study with at least one recorded site in the state. Registry reference only, not medical advice.
Missouri vs all states by indexed in-state trial count
Where this state's ClinicalTrials.gov site count sits among every state with at least one listed trial (coverage density, not care quality)
4,116 Top 33% more indexed trials than 67% of 52 states
States, banded by indexed in-state trial count
Each bar is a band; taller bars hold more states. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov · 2026-08-08
Key findings
What ClinicalTrials.gov does not surface for Missouri on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Missouri open-enrollment share sits below the national baseline.
1,339 of 4,116 in-state trials (32.5%) are recruiting, against 37% nationally (-4.5 percentage points). Counts include every study with at least one recorded site in the state.
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St Louis dominates Missouri's trial geography.
St Louis lists 2,817 of 4,116 in-state trials (68.4%) across 779 named facilities. Cities need five or more listed trials to appear here; locations are as filed by sponsors.
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Breast Cancer is the most-studied condition in Missouri.
80 of 4,116 in-state trials (1.9%) list Breast Cancer. That is a local concentration figure, not a national disease ranking.
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One sponsor accounts for a large share of Missouri trials.
Washington University School of Medicine appears on 491 of 4,116 in-state trials (11.9%). Sponsor identity is as filed on ClinicalTrials.gov.
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1,864 Missouri trials carry a completed status.
1,864 of 4,116 (45.3%) are completed. The open share above is the remainder that still lists recruiting.
Where trials run in Missouri
St Louis carries 2,817 of Missouri's 4,116 indexed trials (68%) across 779 named sites, ahead of Kansas City at 749. 8 cities clear five listed trials, together naming 1,430 distinct sites.
| City | Trials | Listed sites |
|---|---|---|
| St Louis | 2,817 | 779 |
| Kansas City | 749 | 323 |
| Columbia | 306 | 114 |
| Springfield | 143 | 89 |
| Chesterfield | 91 | 53 |
| Saint Charles | 73 | 35 |
| City of Saint Peters | 71 | 20 |
| Creve Coeur | 58 | 17 |
Distinct trials and named sites per city, as filed with ClinicalTrials.gov; cities under five trials omitted. Vintage 2026-08-08.
Trial size small
Missouri's in-state trials target 1,570 patients on average (p27 by trial size among 52 states with enrollment data), smaller studies than most states.
Missouri: in-state trial volume sits in the high tercile
Geography is concentrated: St Louis alone accounts for 68% of Missouri's indexed trials (2,817 of 4,116), with Kansas City a distant second at 749.
Phase mix: 857 Phase 3 vs 1,044 Phase 2 (balanced across stages).
Top condition: Breast Cancer (80 trials); top sponsor Washington University School of Medicine (491).
high-volume · mid-open figures (4,116 trials · 33% open) describe registry geography under the trial size small read, not clinic capacity or protocol fit. Confirm status on ClinicalTrials.gov before acting.
States near Missouri on in-state trial volume
Cross-state peers under the trial size small read (high-volume · mid-open), not the same-state browse list.
Similar high-volume hubs (± open share)
- Alabama · 4,168 trials · 29% recruiting
- Minnesota · 4,506 trials · 36% recruiting
- Tennessee · 3,520 trials · 33% recruiting
- Michigan · 4,790 trials · 34% recruiting
- New Jersey · 3,402 trials · 34% recruiting
Similar mid-open peers (± trial volume)
- Washington · 33% recruiting · 2,795 trials
- North Carolina · 33% recruiting · 5,625 trials
- Connecticut · 32% recruiting · 3,531 trials
- Iowa · 33% recruiting · 1,544 trials
- New Hampshire · 33% recruiting · 471 trials