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ClinicalTrials.gov 1 recruiting now official registry

Brain and Central Nervous System Tumors clinical trials

1 of 55 indexed Brain and Central Nervous System Tumors trials are currently recruiting.

55 US clinical trials · 1 currently recruiting

Brain and Central Nervous System Tumors is the subject of 55 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 40 in Phase 1-2 (earlier-stage). The most active sponsor is Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, running 6 of these trials.

The research picture

Brain and Central Nervous System Tumors has 55 registered US clinical trials, 1 of them open to new participants right now, about 2% of the total.

1
recruiting participants now
2%
of trials open to enrollment
7
in Phase 3–4 (later-stage)
6
top sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Phase 125Phase 215Phase 37

Active & Recent Trials

55 total, page 1 of 2

RECRUITING

3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer

Barbara Ann Karmanos Cancer Institute

NCT00935090

ACTIVE NOT RECRUITING Phase 3 751 participants

Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)

European Organisation for Research and Treatment of Cancer - EORTC

NCT00626990

ACTIVE NOT RECRUITING Phase 3 540 participants

Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma

Eastern Cooperative Oncology Group

NCT00978458

ACTIVE NOT RECRUITING Phase 3 305 participants

Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma

Alliance for Clinical Trials in Oncology

NCT00887146

ACTIVE NOT RECRUITING Phase 2 293 participants

Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma

St. Jude Children's Research Hospital

NCT00602667

COMPLETED Phase 1 3,000 participants

Mafosfamide in Treating Patients With Progressive or Refractory Meningeal Tumors

National Cancer Institute (NCI)

NCT00031928

COMPLETED 631 participants

Study of Tissue and Blood Samples From Patients With High-Grade Glioma

Alliance for Clinical Trials in Oncology

NCT01004887

COMPLETED Phase 3 416 participants

Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

St. Jude Children's Research Hospital

NCT00085202

COMPLETED Phase 2 250 participants

Magnetic Resonance Imaging and Magnetic Resonance Spectroscopic Imaging in Evaluating Patients Who Are Undergoing Treatment for Gliomas

University of California, San Francisco

NCT00274755

COMPLETED Phase 2 244 participants

Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma

Radiation Therapy Oncology Group

NCT00895622

COMPLETED Phase 3 230 participants

Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas

Radiation Therapy Oncology Group

NCT00004259

COMPLETED 110 participants

Risk Factors for Developing a Blood Clot in Patients Who Are Undergoing Cancer Treatment for Newly Diagnosed Gliomas

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00253669

COMPLETED 108 participants

Developing Interview Questions to Estimate Workplace Exposure to Electric and Magnetic Fields

National Institutes of Health Clinical Center (CC)

NCT00340054

COMPLETED Phase 2 105 participants

Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00025675

COMPLETED Phase 3 98 participants

Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain

Vanderbilt-Ingram Cancer Center

NCT00666211

COMPLETED Phase 2 94 participants

Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor

St. Jude Children's Research Hospital

NCT00003211

COMPLETED Phase 2 93 participants

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Alliance for Clinical Trials in Oncology

NCT00003996

COMPLETED Phase 1 92 participants

Hydroxychloroquine, Radiation, and Temozolomide Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00486603

COMPLETED 76 participants

Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders

Case Comprehensive Cancer Center

NCT00255671

COMPLETED Phase 2 60 participants

Leflunomide in Treating Patients With Anaplastic Astrocytoma in First Relapse

Pfizer

NCT00003775

COMPLETED Phase 2 60 participants

Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors

Memorial Sloan Kettering Cancer Center

NCT00470366

COMPLETED Phase 1 56 participants

Carmustine Plus O(6)-Benzylguanine in Treating Patients With Recurrent or Progressive Gliomas of the Brain

Duke University

NCT00003348

COMPLETED 56 participants

Improving the Selection of Patients With Glioblastoma Multiforme for Treatment With Epidermal Growth Factor Receptor Inhibitor Therapies

Alliance for Clinical Trials in Oncology

NCT00897663

COMPLETED Phase 1 53 participants

SCH 66336 in Treating Children With Recurrent or Progressive Brain Tumors

Pediatric Brain Tumor Consortium

NCT00015899

COMPLETED Phase 2 50 participants

Temozolomide in Treating Adults With Newly Diagnosed Primary Malignant Glioblastoma Multiforme

Duke University

NCT00003464

COMPLETED Phase 2 43 participants

Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

Pediatric Brain Tumor Consortium

NCT00047177

COMPLETED Phase 2 40 participants

Penicillamine, Low Copper Diet, and Radiation Therapy in Treating Patients With Glioblastoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00003751

COMPLETED Phase 1 40 participants

Computer Planned Radiation Therapy Plus Chemotherapy in Treating Patients With Glioblastoma Multiforme

Radiation Therapy Oncology Group

NCT00003417

COMPLETED Phase 1 36 participants

O6-benzylguanine and Carmustine in Treating Children With Refractory CNS Tumors

National Cancer Institute (NCI)

NCT00003765

COMPLETED Phase 1 35 participants

Tetra-O-Methyl Nordihydroguaiaretic Acid in Treating Patients With Recurrent High-Grade Glioma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00404248

COMPLETED Phase 1 30 participants

Irinotecan and Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases From Solid Tumors

University of California, Davis

NCT00389584

COMPLETED Phase 2 29 participants

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Anaplastic Astrocytoma

Alliance for Clinical Trials in Oncology

NCT00003621

COMPLETED Phase 1 28 participants

Busulfan in Treating Children and Adolescents With Refractory CNS Cancer

Pediatric Brain Tumor Consortium

NCT00006246

COMPLETED Phase 1 28 participants

PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors

Pediatric Brain Tumor Consortium

NCT01158300

COMPLETED Phase 1 25 participants

Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment

City of Hope Medical Center

NCT00544284

COMPLETED Phase 2 22 participants

Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT00024258

COMPLETED Phase 2 20 participants

Combination Chemotherapy for Patients With Brain Cancer

Dartmouth-Hitchcock Medical Center

NCT00002814

COMPLETED Phase 1 20 participants

Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors

Duke University

NCT00003462

COMPLETED 19 participants

Genetic Study in Patients Receiving Treatment for Hodgkin's Disease or Childhood Brain Tumor

Duke University

NCT00006342

COMPLETED Phase 1 19 participants

Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma

Jonsson Comprehensive Cancer Center

NCT00509431

COMPLETED Phase 1 16 participants

AEE788 and Everolimus in Treating Patients With Recurrent or Relapsed Glioblastoma Multiforme

Novartis Pharmaceuticals

NCT00107237

COMPLETED Phase 1 13 participants

Sirolimus in Treating Patients With Glioblastoma Multiforme

Jonsson Comprehensive Cancer Center

NCT00047073

COMPLETED Phase 1 8 participants

Vaccine Therapy in Treating Patients With Malignant Glioma

Jonsson Comprehensive Cancer Center

NCT00612001

COMPLETED Phase 1 7 participants

Vaccine Therapy in Treating Young Patients Who Are Undergoing Surgery for Malignant Glioma

Jonsson Comprehensive Cancer Center

NCT00107185

COMPLETED NA 6 participants

Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma

Memorial Sloan Kettering Cancer Center

NCT00058370

COMPLETED Phase 1 6 participants

Monoclonal Antibody Therapy in Treating Patients With Recurrent Gliomas

Duke University

NCT00002753

COMPLETED Phase 1 2 participants

Cytochlor, Tetrahydrouridine, and External-Beam Radiation Therapy in Treating Patients With Cancer That Has Spread to the Brain

Brian Lally

NCT00521183

COMPLETED Phase 1

Immunotoxin Therapy in Treating Patients With Malignant Glioma

New Approaches to Brain Tumor Therapy Consortium

NCT00006268

COMPLETED Phase 2

Phenylacetate in Treating Children With Recurrent or Progressive Brain Tumors

Texas Children's Cancer Center

NCT00003241

COMPLETED Phase 3

SU-101 Compared With Procarbazine in Treating Patients With Glioblastoma Multiforme

Pfizer

NCT00003293

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Reading the Brain and Central Nervous System Tumors Trial Landscape

55 indexed Brain and Central Nervous System Tumors studies · 1 recruiting (2%).

Phase mix: 7 late (III/IV) vs 40 early (I/II).

Top sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (6 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Brain and Central Nervous System Tumors?

PlainTrial tracks 55 US clinical trials for Brain and Central Nervous System Tumors, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Brain and Central Nervous System Tumors?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.