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Brain and Central Nervous System Tumors clinical trials
1 of 55 indexed Brain and Central Nervous System Tumors trials are currently recruiting.
55 US clinical trials · 1 currently recruiting
Brain and Central Nervous System Tumors is the subject of 55 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 40 in Phase 1-2 (earlier-stage). The most active sponsor is Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, running 6 of these trials.
The research picture
Brain and Central Nervous System Tumors has 55 registered US clinical trials, 1 of them open to new participants right now, about 2% of the total.
- 1
- recruiting participants now
- 2%
- of trials open to enrollment
- 7
- in Phase 3–4 (later-stage)
- 6
- top sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Active & Recent Trials
55 total, page 1 of 2
3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer
Barbara Ann Karmanos Cancer Institute
NCT00935090
Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)
European Organisation for Research and Treatment of Cancer - EORTC
NCT00626990
Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma
Eastern Cooperative Oncology Group
NCT00978458
Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma
Alliance for Clinical Trials in Oncology
NCT00887146
Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma
St. Jude Children's Research Hospital
NCT00602667
Mafosfamide in Treating Patients With Progressive or Refractory Meningeal Tumors
National Cancer Institute (NCI)
NCT00031928
Study of Tissue and Blood Samples From Patients With High-Grade Glioma
Alliance for Clinical Trials in Oncology
NCT01004887
Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor
St. Jude Children's Research Hospital
NCT00085202
Magnetic Resonance Imaging and Magnetic Resonance Spectroscopic Imaging in Evaluating Patients Who Are Undergoing Treatment for Gliomas
University of California, San Francisco
NCT00274755
Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma
Radiation Therapy Oncology Group
NCT00895622
Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas
Radiation Therapy Oncology Group
NCT00004259
Risk Factors for Developing a Blood Clot in Patients Who Are Undergoing Cancer Treatment for Newly Diagnosed Gliomas
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT00253669
Developing Interview Questions to Estimate Workplace Exposure to Electric and Magnetic Fields
National Institutes of Health Clinical Center (CC)
NCT00340054
Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT00025675
Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain
Vanderbilt-Ingram Cancer Center
NCT00666211
Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor
St. Jude Children's Research Hospital
NCT00003211
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Alliance for Clinical Trials in Oncology
NCT00003996
Hydroxychloroquine, Radiation, and Temozolomide Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT00486603
Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders
Case Comprehensive Cancer Center
NCT00255671
Leflunomide in Treating Patients With Anaplastic Astrocytoma in First Relapse
Pfizer
NCT00003775
Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors
Memorial Sloan Kettering Cancer Center
NCT00470366
Carmustine Plus O(6)-Benzylguanine in Treating Patients With Recurrent or Progressive Gliomas of the Brain
Duke University
NCT00003348
Improving the Selection of Patients With Glioblastoma Multiforme for Treatment With Epidermal Growth Factor Receptor Inhibitor Therapies
Alliance for Clinical Trials in Oncology
NCT00897663
SCH 66336 in Treating Children With Recurrent or Progressive Brain Tumors
Pediatric Brain Tumor Consortium
NCT00015899
Temozolomide in Treating Adults With Newly Diagnosed Primary Malignant Glioblastoma Multiforme
Duke University
NCT00003464
Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor
Pediatric Brain Tumor Consortium
NCT00047177
Penicillamine, Low Copper Diet, and Radiation Therapy in Treating Patients With Glioblastoma
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT00003751
Computer Planned Radiation Therapy Plus Chemotherapy in Treating Patients With Glioblastoma Multiforme
Radiation Therapy Oncology Group
NCT00003417
O6-benzylguanine and Carmustine in Treating Children With Refractory CNS Tumors
National Cancer Institute (NCI)
NCT00003765
Tetra-O-Methyl Nordihydroguaiaretic Acid in Treating Patients With Recurrent High-Grade Glioma
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT00404248
Irinotecan and Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases From Solid Tumors
University of California, Davis
NCT00389584
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Anaplastic Astrocytoma
Alliance for Clinical Trials in Oncology
NCT00003621
Busulfan in Treating Children and Adolescents With Refractory CNS Cancer
Pediatric Brain Tumor Consortium
NCT00006246
PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors
Pediatric Brain Tumor Consortium
NCT01158300
Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment
City of Hope Medical Center
NCT00544284
Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors
Memorial Sloan Kettering Cancer Center
NCT00024258
Combination Chemotherapy for Patients With Brain Cancer
Dartmouth-Hitchcock Medical Center
NCT00002814
Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors
Duke University
NCT00003462
Genetic Study in Patients Receiving Treatment for Hodgkin's Disease or Childhood Brain Tumor
Duke University
NCT00006342
Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma
Jonsson Comprehensive Cancer Center
NCT00509431
AEE788 and Everolimus in Treating Patients With Recurrent or Relapsed Glioblastoma Multiforme
Novartis Pharmaceuticals
NCT00107237
Sirolimus in Treating Patients With Glioblastoma Multiforme
Jonsson Comprehensive Cancer Center
NCT00047073
Vaccine Therapy in Treating Patients With Malignant Glioma
Jonsson Comprehensive Cancer Center
NCT00612001
Vaccine Therapy in Treating Young Patients Who Are Undergoing Surgery for Malignant Glioma
Jonsson Comprehensive Cancer Center
NCT00107185
Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma
Memorial Sloan Kettering Cancer Center
NCT00058370
Monoclonal Antibody Therapy in Treating Patients With Recurrent Gliomas
Duke University
NCT00002753
Cytochlor, Tetrahydrouridine, and External-Beam Radiation Therapy in Treating Patients With Cancer That Has Spread to the Brain
Brian Lally
NCT00521183
Immunotoxin Therapy in Treating Patients With Malignant Glioma
New Approaches to Brain Tumor Therapy Consortium
NCT00006268
Phenylacetate in Treating Children With Recurrent or Progressive Brain Tumors
Texas Children's Cancer Center
NCT00003241
SU-101 Compared With Procarbazine in Treating Patients With Glioblastoma Multiforme
Pfizer
NCT00003293
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 25 |
| Phase 2 | 15 |
| Phase 3 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Brain and Central Nervous System Tumors Trial Landscape
55 indexed Brain and Central Nervous System Tumors studies · 1 recruiting (2%).
Phase mix: 7 late (III/IV) vs 40 early (I/II).
Top sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (6 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Brain and Central Nervous System Tumors?
PlainTrial tracks 55 US clinical trials for Brain and Central Nervous System Tumors, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Brain and Central Nervous System Tumors?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.