Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 18 recruiting now official registry

Menopause clinical trials

18 of 55 indexed Menopause trials are currently recruiting.

55 US clinical trials · 18 currently recruiting

Menopause is the subject of 55 registered US clinical trials on ClinicalTrials.gov, 18 of them currently open to new participants. 12 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 6 of these trials.

The research picture

Menopause has 55 registered US clinical trials, 18 of them open to new participants right now, about 33% of the total.

18
recruiting participants now
33%
of trials open to enrollment
12
in Phase 3–4 (later-stage)
6
top sponsor: University of Colorado, Denver
Phase 14Phase 213Phase 33Phase 49

Active & Recent Trials

55 total, page 1 of 2

RECRUITING 500,000 participants

Apple Women's Health Study

Apple

NCT04196595

RECRUITING 160 participants

Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

University of Minnesota

NCT04439370

RECRUITING NA 120 participants

Hot Flashes and Neurovascular Function in Women

Mayo Clinic

NCT05193968

RECRUITING Phase 2 104 participants

Effects of Hemp-Derived Cannabinoids on Menopause Symptoms

Washington State University

NCT07393672

RECRUITING Phase 4 100 participants

Cardiometabolic Consequences of the Loss of Ovarian Function

University of Colorado, Denver

NCT06264882

RECRUITING Phase 2 100 participants

Impact of Cannabinoids on Menopause Symptoms

Washington State University

NCT06831916

RECRUITING 80 participants

Menopause Transition, Sex Hormone Deficiency and Autonomic and Vascular Function

University of Minnesota

NCT06490146

RECRUITING Early Phase 1 75 participants

Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

University of Missouri-Columbia

NCT06787066

RECRUITING Early Phase 1 75 participants

Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

University of Missouri-Columbia

NCT06417177

RECRUITING Phase 4 61 participants

Efficacy of Suvorexant in the Treatment of Insomnia in Midlife Women With Pre-Diabetes

Brigham and Women's Hospital

NCT05593653

RECRUITING 60 participants

The Cardiovascular Impact of Hot Flushes

University of Minnesota

NCT05251324

RECRUITING NA 51 participants

Efficacy and Safety of Shatavari for Treatment of Menopausal Symptoms in Women: A Randomized, Double-blind, Three-arm, Parallel, Placebo-controlled Study

SF Research Institute

NCT06716554

RECRUITING NA 40 participants

Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females

University of Virginia

NCT06480695

RECRUITING NA 30 participants

Improving Sympathetic Activity, Hot Flashes, and Sleep in Midlife Women Using Inspiratory Muscle Strength Training

Mayo Clinic

NCT06743269

RECRUITING Phase 2 30 participants

The Anabolic Effect of Testosterone on Pelvic Floor Muscles

Brigham and Women's Hospital

NCT06111209

RECRUITING NA 30 participants

Depression, Aging, Stress and Heart Health Study

University of North Carolina, Chapel Hill

NCT05570721

RECRUITING Phase 4 24 participants

Role of Menopause in Thermoregulation

Penn State University

NCT06798571

RECRUITING NA 20 participants

Choline Dose Ranging in Postmenopausal Women

Julie Dumas

NCT06924541

ACTIVE NOT RECRUITING Phase 2 100 participants

PhytoSERM to Prevent Menopause Associated Decline in Brain Metabolism and Cognition

Roberta Brinton

NCT05664477

ACTIVE NOT RECRUITING Phase 4 55 participants

Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study)

University of Colorado, Denver

NCT05057546

ACTIVE NOT RECRUITING Early Phase 1 22 participants

MitoQ and Exercise Effects on Vascular Health

University of Colorado, Denver

NCT05686967

COMPLETED Phase 3 1,845 participants

A Safety and Efficacy Study of the Combination Estradiol and Progesterone to Treat Vasomotor Symptoms

TherapeuticsMD

NCT01942668

COMPLETED NA 500 participants

Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes

Radicle Science

NCT06749288

COMPLETED Phase 3 450 participants

Study of the Safety and Efficacy of Desvenlafaxine Succinate for Vasomotor Symptoms in Postmenopausal Women

Wyeth is now a wholly owned subsidiary of Pfizer

NCT00369434

COMPLETED NA 410 participants

MyMenoPlan: Online Resource for Improving Women's Menopause Knowledge and Informed Decision-making

University of California, San Diego

NCT05299983

COMPLETED NA 355 participants

MsFLASH-02: Interventions for Relief of Menopausal Symptoms: A 3-by-2 Factorial Design Examining Yoga, Exercise, and Omega-3 Supplementation

Fred Hutchinson Cancer Center

NCT01178892

COMPLETED Phase 2 350 participants

Study of the Efficacy of ESTRATEST® H.S. Tablets in Relieving Menopausal Symptoms in Estrogenized Postmenopausal Women

Solvay Pharmaceuticals

NCT00141570

COMPLETED Phase 2 203 participants

A Safety and Efficacy Study of Estradiol Vaginal Capsule in Postmenopausal Women With Vulvovaginal Atrophy

Warner Chilcott

NCT02670785

COMPLETED Phase 2 172 participants

Perimenopausal Estrogen Replacement Therapy Study

University of North Carolina, Chapel Hill

NCT01308814

COMPLETED NA 154 participants

Behavioral Treatment of Menopausal Insomnia; Sleep and Daytime Outcomes

Christopher Drake

NCT01933295

COMPLETED NA 150 participants

Development and Evaluation of a Hormone Replacement Therapy Decision-Aid

US Department of Veterans Affairs

NCT00012909

COMPLETED NA 150 participants

Caria: Digital Intervention for Menopause Symptom

University of Illinois at Chicago

NCT04882982

COMPLETED Phase 2 125 participants

Hormone Replacement in Menopausal Women With Epilepsy

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00027209

COMPLETED Phase 2 112 participants

Use of Black Cohosh and Red Clover for the Relief of Menopausal Symptoms

National Center for Complementary and Integrative Health (NCCIH)

NCT00066144

COMPLETED Phase 2 105 participants

FP-101 Versus Placebo in the Treatment of Menopausal Vasomotor Symptoms

Fervent Pharmaceuticals

NCT05312567

COMPLETED Early Phase 1 100 participants

Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women

University of Colorado, Denver

NCT02042196

COMPLETED Phase 2 96 participants

Research Investigation of Soy and Estrogen

University of Illinois at Chicago

NCT00997893

COMPLETED 72 participants

Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

National Eye Institute (NEI)

NCT00471731

COMPLETED 66 participants

Metabolic and Psychological Changes Associated With Menopause Among Women With HIV

Massachusetts General Hospital

NCT01142817

COMPLETED Phase 4 60 participants

Hormone Estradiol Replacement Therapy Additional Herbals

Trieu, Nguyen Thi, M.D.

NCT02618148

COMPLETED NA 53 participants

Following Lipectomy to Understand Adipose Tissue Re-accumulation

University of Colorado, Denver

NCT00995631

COMPLETED Phase 2 50 participants

Effects of Tibilone on Bone Density, Menopause Symptoms and Breast Density in Women After Prophylactic Oophorectomy

Dana-Farber Cancer Institute

NCT00165204

COMPLETED Phase 3 50 participants

Therapy to Prevent Sexual Pain in Breast Cancer Survivors

OHSU Knight Cancer Institute

NCT01539317

COMPLETED Phase 4 40 participants

Estrogen Variability and Irritability During the Menopause Transition

University of North Carolina, Chapel Hill

NCT05388656

COMPLETED NA 40 participants

Pilot Study of Stellate Ganglion Injection to Provide Relief From Hot Flushes

Northwestern University

NCT00992914

COMPLETED NA 38 participants

Reducing the Experience of Menopausal Symptoms Through Temperature

Wake Forest University Health Sciences

NCT03937466

COMPLETED NA 30 participants

The Role of the Gut Microbiota in Estrogen Metabolism and Dietary Flax as a Potential Modulator.

Colorado State University

NCT03183102

COMPLETED Phase 4 29 participants

Duloxetine for Menopausal Depression

Massachusetts General Hospital

NCT01117857

COMPLETED Phase 4 25 participants

Effect of Nuvigil on Fatigue

Massachusetts General Hospital

NCT01460628

COMPLETED Phase 2 24 participants

A TSEC for Symptom Management in Menopausal Women With Multiple Sclerosis

University of California, San Francisco

NCT02710214

Page 1 of 2 Next →

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 13
Phase 3 3
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Menopause Trial Landscape

55 indexed Menopause studies · 18 recruiting (33%).

Phase mix: 12 late (III/IV) vs 17 early (I/II).

Top sponsor: University of Colorado, Denver (6 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Menopause?

PlainTrial tracks 55 US clinical trials for Menopause, of which 18 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Menopause?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.