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Menopause
Open-data reference.
55 US clinical trials · 18 currently recruiting
Active & Recent Trials
Apple Women's Health Study
Apple
NCT04196595
Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
University of Minnesota
NCT04439370
Hot Flashes and Neurovascular Function in Women
Mayo Clinic
NCT05193968
Effects of Hemp-Derived Cannabinoids on Menopause Symptoms
Washington State University
NCT07393672
Cardiometabolic Consequences of the Loss of Ovarian Function
University of Colorado, Denver
NCT06264882
Impact of Cannabinoids on Menopause Symptoms
Washington State University
NCT06831916
Menopause Transition, Sex Hormone Deficiency and Autonomic and Vascular Function
University of Minnesota
NCT06490146
Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms
University of Missouri-Columbia
NCT06787066
Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
University of Missouri-Columbia
NCT06417177
Efficacy of Suvorexant in the Treatment of Insomnia in Midlife Women With Pre-Diabetes
Brigham and Women's Hospital
NCT05593653
The Cardiovascular Impact of Hot Flushes
University of Minnesota
NCT05251324
Efficacy and Safety of Shatavari for Treatment of Menopausal Symptoms in Women: A Randomized, Double-blind, Three-arm, Parallel, Placebo-controlled Study
SF Research Institute
NCT06716554
Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females
University of Virginia
NCT06480695
Improving Sympathetic Activity, Hot Flashes, and Sleep in Midlife Women Using Inspiratory Muscle Strength Training
Mayo Clinic
NCT06743269
The Anabolic Effect of Testosterone on Pelvic Floor Muscles
Brigham and Women's Hospital
NCT06111209
Depression, Aging, Stress and Heart Health Study
University of North Carolina, Chapel Hill
NCT05570721
Role of Menopause in Thermoregulation
Penn State University
NCT06798571
Choline Dose Ranging in Postmenopausal Women
Julie Dumas
NCT06924541
PhytoSERM to Prevent Menopause Associated Decline in Brain Metabolism and Cognition
Roberta Brinton
NCT05664477
Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study)
University of Colorado, Denver
NCT05057546
MitoQ and Exercise Effects on Vascular Health
University of Colorado, Denver
NCT05686967
A Safety and Efficacy Study of the Combination Estradiol and Progesterone to Treat Vasomotor Symptoms
TherapeuticsMD
NCT01942668
Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes
Radicle Science
NCT06749288
Study of the Safety and Efficacy of Desvenlafaxine Succinate for Vasomotor Symptoms in Postmenopausal Women
Wyeth is now a wholly owned subsidiary of Pfizer
NCT00369434
MyMenoPlan: Online Resource for Improving Women's Menopause Knowledge and Informed Decision-making
University of California, San Diego
NCT05299983
MsFLASH-02: Interventions for Relief of Menopausal Symptoms: A 3-by-2 Factorial Design Examining Yoga, Exercise, and Omega-3 Supplementation
Fred Hutchinson Cancer Center
NCT01178892
Study of the Efficacy of ESTRATEST® H.S. Tablets in Relieving Menopausal Symptoms in Estrogenized Postmenopausal Women
Solvay Pharmaceuticals
NCT00141570
A Safety and Efficacy Study of Estradiol Vaginal Capsule in Postmenopausal Women With Vulvovaginal Atrophy
Warner Chilcott
NCT02670785
Perimenopausal Estrogen Replacement Therapy Study
University of North Carolina, Chapel Hill
NCT01308814
Behavioral Treatment of Menopausal Insomnia; Sleep and Daytime Outcomes
Christopher Drake
NCT01933295
Development and Evaluation of a Hormone Replacement Therapy Decision-Aid
US Department of Veterans Affairs
NCT00012909
Caria: Digital Intervention for Menopause Symptom
University of Illinois at Chicago
NCT04882982
Hormone Replacement in Menopausal Women With Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00027209
Use of Black Cohosh and Red Clover for the Relief of Menopausal Symptoms
National Center for Complementary and Integrative Health (NCCIH)
NCT00066144
FP-101 Versus Placebo in the Treatment of Menopausal Vasomotor Symptoms
Fervent Pharmaceuticals
NCT05312567
Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
University of Colorado, Denver
NCT02042196
Research Investigation of Soy and Estrogen
University of Illinois at Chicago
NCT00997893
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
National Eye Institute (NEI)
NCT00471731
Metabolic and Psychological Changes Associated With Menopause Among Women With HIV
Massachusetts General Hospital
NCT01142817
Hormone Estradiol Replacement Therapy Additional Herbals
Trieu, Nguyen Thi, M.D.
NCT02618148
Following Lipectomy to Understand Adipose Tissue Re-accumulation
University of Colorado, Denver
NCT00995631
Effects of Tibilone on Bone Density, Menopause Symptoms and Breast Density in Women After Prophylactic Oophorectomy
Dana-Farber Cancer Institute
NCT00165204
Therapy to Prevent Sexual Pain in Breast Cancer Survivors
OHSU Knight Cancer Institute
NCT01539317
Estrogen Variability and Irritability During the Menopause Transition
University of North Carolina, Chapel Hill
NCT05388656
Pilot Study of Stellate Ganglion Injection to Provide Relief From Hot Flushes
Northwestern University
NCT00992914
Reducing the Experience of Menopausal Symptoms Through Temperature
Wake Forest University Health Sciences
NCT03937466
The Role of the Gut Microbiota in Estrogen Metabolism and Dietary Flax as a Potential Modulator.
Colorado State University
NCT03183102
Duloxetine for Menopausal Depression
Massachusetts General Hospital
NCT01117857
Effect of Nuvigil on Fatigue
Massachusetts General Hospital
NCT01460628
A TSEC for Symptom Management in Menopausal Women With Multiple Sclerosis
University of California, San Francis
NCT02710214
Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women
University of Texas Southwestern Medical Center
NCT03692572
Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function
University of Colorado, Denver
NCT03112226
Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder
University of Pennsylvania
NCT00626340
Placebo Controlled Study of Atomoxetine in the Treatment of Mild to Moderate Cognitive Difficulties in Menopausal Women
University of Pennsylvania
NCT00611533
Buccal Estrogen in Toothpaste Study: Systemic Absorption of Estradiol When Administered Mixed With Toothpaste in Postmenopausal or Surgically Menopausal Women
National Center for Research Resources (NCRR)
NCT00029757
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 4 |
| Phase 2 | 13 |
| Phase 3 | 3 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Menopause Trial Landscape
ClinicalTrials.gov lists 55 US studies indexed under Menopause, and 18 of those are currently open to recruitment — roughly 33% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Menopause shows 12 late-stage studies (Phase 3 and Phase 4 combined) alongside 17 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Menopause is led by University of Colorado, Denver with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 55 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Menopause?
PlainTrial tracks 55 US clinical trials for Menopause, of which 18 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Menopause?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.