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ACTIVE NOT RECRUITING Phase 3

Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)

NCT00626990 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may kill more tumor cells. It is not yet known whether giving temozolomide during and/or after radiation therapy is more effective than radiation therapy alone in treating anaplastic glioma. PURPOSE: This randomized phase III trial is studying giving temozolomide during and/or after radiation therapy to see how well it works compared to radiation therapy alone in treating patients with anaplastic glioma.

Interventions

  • OTHER laboratory biomarker analysis
  • DRUG temozolomide
  • PROCEDURE quality-of-life assessment
  • GENETIC DNA methylation analysis
  • PROCEDURE adjuvant therapy

Study Locations (20)

Florida

  • University of Florida — Gainesville
  • Mayo Clinic in Florida — Jacksonville
  • Florida Hospital — Orlando

Indiana

  • Oncology Associates PC — Fort Wayne
  • Parkview Hospital — Fort Wayne
  • Saint Vincent Oncology Center — Indianapolis

California

  • Cedars-Sinai Medical Center — Los Angeles
  • UCSF University of California San Francisco Medical Center-Mount Zion — San Francisco

Georgia

  • Emory University — Atlanta
  • Memorial Health University Medical Center — Savannah

Illinois

  • Northwestern University — Chicago
  • Loyola University Medical Center — Maywood

Iowa

  • McFarland Clinic — Ames
  • June E. Nylen Cancer Center — Sioux City

Kansas

  • Via Christi Regional Medical Center — Wichita
  • Wesley Medical Center — Wichita

Massachusetts

  • Boston Medical Center — Boston
  • Brigham and Women's Hospital — Boston

Trial Details

FieldValue
Enrollment Target 751 participants
Start Date 2007-12
Est. Completion 2029-12
Phase Phase 3

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00626990

The ClinicalTrials.gov registry entry for NCT00626990 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 751 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is European Organisation for Research and Treatment of Cancer - EORTC, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Brain and Central Nervous System Tumors appearing as the primary indexed condition, and to 5 interventions — of which laboratory biomarker analysis is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00626990 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, Indiana, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00626990 about?

NCT00626990 is a clinical study titled "Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)". RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may...

What is the current status of trial NCT00626990?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 751 participants. The study started on 2007-12. Estimated completion is 2029-12.

What conditions does trial NCT00626990 study?

This clinical trial studies the following conditions: Brain and Central Nervous System Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00626990?

The interventions under investigation include: laboratory biomarker analysis (OTHER), temozolomide (DRUG), quality-of-life assessment (PROCEDURE), DNA methylation analysis (GENETIC), adjuvant therapy (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00626990?

This trial is sponsored by European Organisation for Research and Treatment of Cancer - EORTC, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00626990 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial