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COMPLETED Phase 2

Penicillamine, Low Copper Diet, and Radiation Therapy in Treating Patients With Glioblastoma

NCT00003751 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Penicillamine may stop the growth of glioblastomas by stopping blood flow to the tumor. A diet low in copper may interfere with the growth of brain tumor cells. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining these therapies may be effective in treating glioblastoma. PURPOSE: Phase II trial to study the effectiveness of penicillamine, a low copper diet, and radiation therapy in treating patients who have newly diagnosed glioblastoma.

Interventions

  • RADIATION radiation therapy
  • DRUG penicillamine

Study Locations (9)

Alabama

  • University of Alabama Comprehensive Cancer Center — Birmingham

Florida

  • H. Lee Moffitt Cancer Center and Research Institute — Tampa

Georgia

  • Emory University School of Medicine — Atlanta

Maryland

  • Johns Hopkins Oncology Center — Baltimore

Massachusetts

  • Massachusetts General Hospital Cancer Center — Boston

Michigan

  • Henry Ford Hospital — Detroit

North Carolina

  • Comprehensive Cancer Center of Wake Forest University Baptist Medical Center — Winston-Salem

Pennsylvania

  • University of Pennsylvania Cancer Center — Philadelphia

Trial Details

FieldValue
Enrollment Target 40 participants
Start Date 1999-03
Est. Completion 2005-07
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00003751

The ClinicalTrials.gov registry entry for NCT00003751 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, which has 311 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Brain and Central Nervous System Tumors appearing as the primary indexed condition, and to 2 interventions — of which radiation therapy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00003751 reports 9 study locations spanning 9 distinct geographic areas — top geographies include Alabama, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00003751 about?

NCT00003751 is a clinical study titled "Penicillamine, Low Copper Diet, and Radiation Therapy in Treating Patients With Glioblastoma". RATIONALE: Penicillamine may stop the growth of glioblastomas by stopping blood flow to the tumor. A diet low in copper may interfere with the growth of brain tumor cells. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining these therapies may be effective in treating glioblas...

What is the current status of trial NCT00003751?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 1999-03. Estimated completion is 2005-07.

What conditions does trial NCT00003751 study?

This clinical trial studies the following conditions: Brain and Central Nervous System Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00003751?

The interventions under investigation include: radiation therapy (RADIATION), penicillamine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00003751?

This trial is sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, which has 311 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00003751 being conducted?

This trial has 9 study locations across Alabama, Florida, Georgia, Maryland, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial