Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Constipation: full-pipeline trial registry
15 of 55 indexed Constipation trials are currently recruiting.
Corpus placement: #254 of 28,707 conditions by registered trial count.
55 US clinical trials · 15 currently recruiting · #254 of 28,707 conditions by registered trial count
Constipation: 55 US clinical trials tracked, 15 recruiting.
Constipation is the subject of 55 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 16 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is Mayo Clinic, running 5 of these trials.
Enrollment posture brief
Registry condition constipation
OPEN 15 | RECR 27% | LATE 16 | EARLY 13 | RANK #254 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Atherosclerotic Cardiovascular Disease (27% recruiting · 22 trials)
Constipation lists 15 open slots (27% of 55 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Constipation on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Constipation is recruiting below its size-band peers.
15 of 55 indexed trials (27.3%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Constipation trials is spread across many organizations.
Mayo Clinic accounts for 5 of 55 trials (9.1%). 41 distinct sponsors appear on at least one study for this condition label.
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Most Constipation trials plan to enrol fewer than 100 people.
Median target enrolment is 64 among the 55 trials that report a genuine target (sentinel values excluded). 35 of those (63.6%) plan for fewer than 100 participants.
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Constipation research is mostly interventional.
48 interventional and 7 observational studies make up this index (87.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
55 total, page 1 of 2
Indiana University Gastrointestinal Motility Diagnosis Registry
Indiana University
NCT04506593
Preop Laxatives in Robotic Urologic Surgery
Chad R. Tracy
NCT05805436
Management of Dyssynergic Defecation
Mayo Clinic
NCT07225803
Understanding Mechanisms of Normal and Disordered Defecation
Mayo Clinic
NCT03842007
Optimization of Postoperative Bowel Habits
Wake Forest University Health Sciences
NCT06335797
Pre-operative Polyethylene Glycol 3350 for Minimally Invasive Urogynecologic Surgery
University Hospitals Cleveland Medical Center
NCT06159777
A Study of Herbal Supplements in Cancer Survivors With Constipation
Memorial Sloan Kettering Cancer Center
NCT07091084
Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen
Indiana University
NCT05821309
Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis
The University of Texas Health Science Center, Houston
NCT05989763
Impact of Weizmannia (Bacillus) Coagulans JBI-YZ6.3 on Gut Health and Fecal Microbiome Changes
Lindenwood University
NCT07388264
Impact of the Inno Cleanse Dietary Supplement on Gut Health and Associated Variables in Healthy Men and Women
University of Memphis
NCT07215351
Assessing Tenapanor as a Treatment of CF-related Constipation.
Massachusetts General Hospital
NCT06810167
Fecobionics in Biofeedback Therapy in Dyssynergia Patients
The California Medical Innovations Institute
NCT05807321
A Study of Microbiome Transplantation for the Treatment of Constipation and/or Significant Bloating in Patients With Systemic Sclerosis
The University of Texas Health Science Center, Houston
NCT06827977
Pyridostigmine for the Treatment of Constipation in Parkinson Disease
University of Vermont Medical Center
NCT05603715
A Study to Assess Maternal and Fetal Outcomes After Taking Prucalopride During Pregnancy
Takeda
NCT04961840
Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks
University of Arizona
NCT07099222
Use of a Squatting Assist Device in Patients With Constipation
Mayo Clinic
NCT02877394
Microbiota Transplant Therapy for Children With Both Autism Spectrum Disorder and Gastrointestinal Disorders
Gut-Brain-Axis Therapeutics
NCT06503978
MTT for Children With ASD Who Have Gastrointestinal Disorders
Arizona State University
NCT04182633
Neostigmine and Glycopyrrolate by Iontophoresis
James J. Peters Veterans Affairs Medical Center
NCT06351995
Study Evaluating Long-Term Safety of MOA-728 in Participants With Opioid-Induced Constipation
Bausch Health Americas
NCT00804141
Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
NCT00256932
An Open Label Study of Chronic Use of BLI400 Laxative in Constipated Adults
Braintree Laboratories
NCT02819310
Extended Use of Polyethyleneglycol3350 Laxative in Constipated Patients
Braintree Laboratories
NCT00153153
An Open Label Study of Chronic Polyethyleneglycol3350 Use in Constipated Patients
Braintree Laboratories
NCT00164125
Treatment of Functional Bowel Disorders
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00006157
Development and Validation of the Automated Evaluation of Gastrointestinal Symptoms (AEGIS) Platform
Cedars-Sinai Medical Center
NCT02436057
Orally Administered ENT-01 for Parkinson's Disease-Related Constipation (KARMET)
Enterin
NCT03781791
Safety and Efficacy of Lubiprostone in Pediatric Patients With Constipation
Sucampo Pharma Americas
NCT00452335
Guideline to Implementation: A Rapid Clinical Care Pathway to Care for Patients Affected by Chronic Constipation
University of Michigan
NCT06352827
Open Label Tolerability Study of ISOThrive Prebiotic Nectar (MIMO) in Subjects With Constipation
ISOThrive
NCT04677634
ISE to Support Constipation Management
Children's Hospital Medical Center, Cincinnati
NCT02977858
Comparison of PolyethyleneGlycol and Placebo for Relief of Constipation From Constipating Medications
Braintree Laboratories
NCT00153127
Perineal Self-Acupressure
University of California, Los Angeles
NCT01867944
Effect of Preoperative Fiber on Postoperative Bowel Function
University of Massachusetts, Worcester
NCT04882995
Sierra High Definition Ano-Rectal Manometry
Augusta University
NCT01300884
Tolerability and Functional Assessment of a Novel Children's Synbiotic
Seed Health
NCT04534036
Fiber Regimens for Constipation Symptoms
University of Texas Southwestern Medical Center
NCT03845673
Preference of Tegaserod vs. PEG 3350 in Patients With Constipation
Novartis
NCT00171522
A Probiotic Blend Reduces Gastrointestinal Symptoms and Positively Impacts Microbiota Modulation in a Randomized Study
The Center for Applied Health Sciences
NCT05614726
Evaluation of Safety and Tolerability of ENT-01 for the Treatment of Parkinson's Disease Related Constipation
Enterin
NCT03047629
Study to Gather Information on the Acceptability of a New Flavor System With Increasing Levels of 2, 4, 6 g or Higher of Mannitol for PEG 3350 in Subjects Having Infrequent Bowel Movements.
Bayer
NCT04534465
Phase 2 Study to Evaluate Safety and Efficacy of RM-131 Administered to Patients With Chronic Constipation
Motus Therapeutics
NCT01781104
Study Evaluating the Safety of MOA-728 Administered Orally to Healthy Subjects
Bausch Health Americas
NCT00311350
Biomarkers for Intestinal Permeability in Patients With Constipation
Mayo Clinic
NCT02246647
AcuGraph and Digestive Symptoms
Logan College of Chiropractic
NCT00846794
Lubiprostone in Patients With Multiple Sclerosis Associated Constipation
University of Rochester
NCT01236534
Fiber Formula Study Among Radiation Oncology Patients
Mayo Clinic
NCT00888147
Biofeedback Treatment for Functional Constipation
University of California, San Francisco
NCT00502957
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 8 |
| Phase 3 | 6 |
| Phase 4 | 10 |
Top Sponsors
Named interventions
Most-linked intervention names on Constipation records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Constipation trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Constipation page
55 registered trials, 15 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 15 Constipation trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Mayo Clinic sponsors the most Constipation trials on record, review their full trial history before evaluating a specific study. See Mayo Clinic's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Constipation condition card totals 55 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.